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Proceedings of the National Academy of Sciences of Belarus, Medical series

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SUPPRESSION OF CD8+ T-LYMPHOCYTES AND NATURAL KILLER CELLS CYTOTOXIC FUNCTION BY HUMAN OLFACTORY MUCOSA-DERIVED MESENCHYMAL STEM CELLS

Abstract

In this study, the immunomodulatory effects of human olfactory mucosa-derived stem cells (hOM-MSCs) against the cell-mediated cytotoxic activity of cytotoxic T-lymphocytes (CTLs) and natural killer cells (NKCs) are evaluated. It has been shown that the immunomodulatory activity is realized through a suppression of cytotoxic mechanisms (decrease in the expression of perforin, granzime B, CD107a), which eventually leads to a reduced ability to induce apoptosis in target tumor cells. The obtained results can be applied for development of biomedical cell products based on hOM-MSCs to treat diseases in which the leading role is played by the cytotoxic activity of CTL and NKCs. 

For citations:


Antonevich N.H., Hancharou A.Y., Buschik O.V., Rynda A.G., Chekan V.L., Strinkevich E.A. SUPPRESSION OF CD8+ T-LYMPHOCYTES AND NATURAL KILLER CELLS CYTOTOXIC FUNCTION BY HUMAN OLFACTORY MUCOSA-DERIVED MESENCHYMAL STEM CELLS. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(4):7-16. (In Russ.)

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ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)