SUPPRESSION OF CD8+ T-LYMPHOCYTES AND NATURAL KILLER CELLS CYTOTOXIC FUNCTION BY HUMAN OLFACTORY MUCOSA-DERIVED MESENCHYMAL STEM CELLS
Abstract
In this study, the immunomodulatory effects of human olfactory mucosa-derived stem cells (hOM-MSCs) against the cell-mediated cytotoxic activity of cytotoxic T-lymphocytes (CTLs) and natural killer cells (NKCs) are evaluated. It has been shown that the immunomodulatory activity is realized through a suppression of cytotoxic mechanisms (decrease in the expression of perforin, granzime B, CD107a), which eventually leads to a reduced ability to induce apoptosis in target tumor cells. The obtained results can be applied for development of biomedical cell products based on hOM-MSCs to treat diseases in which the leading role is played by the cytotoxic activity of CTL and NKCs.
About the Authors
N. H. Antonevich
Republican Research and Practical Center for Epidemiology and Microbiology, Minsk
Belarus
Belarus
Researcher
23, Filimonov Str., 220114
A. Y. Hancharou
Republican Research and Practical Center for Epidemiology and Microbiology, Minsk
Belarus
Belarus
Ph. D. (Med.), Head of the Laboratory
23, Filimonov Str., 220114
O. V. Buschik
Republican Research and Practical Center for Epidemiology and Microbiology, Minsk
Belarus
Belarus
Junior Researcher
23, Filimonov Str., 220114
A. G. Rynda
Republican Research and Practical Center for Epidemiology and Microbiology, Minsk
Belarus
Belarus
Junior Researcher
23, Filimonov Str., 220114
V. L. Chekan
Belarusian Medical Academy of Postgraduate Education, Minsk
Belarus
Belarus
Ph. D. (Med.), Assistant Professor
8, Sukhaya Str., 220004
E. A. Strinkevich
Belarusian Medical Academy of Postgraduate Education, Minsk
Belarus
Belarus
Ph. D. (Med.), Assistant
8, Sukhaya Str., 220004
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Review
For citations:
Antonevich N.H., Hancharou A.Y., Buschik O.V., Rynda A.G., Chekan V.L., Strinkevich E.A. SUPPRESSION OF CD8+ T-LYMPHOCYTES AND NATURAL KILLER CELLS CYTOTOXIC FUNCTION BY HUMAN OLFACTORY MUCOSA-DERIVED MESENCHYMAL STEM CELLS. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(4):7-16. (In Russ.)
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