CORRECTION OF METABOLIC DISORDERS DUE TO AMINO ACID COMPOSITIONS AT INTERMITTENT ALCOHOL INTOXICATION
Abstract
The efficiency of amino acid compositions during the correction of the disorders due to intermittent alcohol intoxication in liver, heart and blood of experimental animals is researched. Intermittent alcohol intoxication is followed by the activation of POL processes in blood and liver and by the depletion of the antioxidant system capacity. Changes in the free amino acid pool at alcohol intoxication are expressed in a reduction of the levels of 9 amino acids and ethanolamine in the liver, and also 5 amino acids and ethanolamine in the myocardium. The amino acid composition Tritarg, in comparison with Tavamin and Neyramin has a more expressed correction effect on the POL activation in the blood and the liver. Administration of Tritarg, unlike Tavamin and Neyramin, leads to an increase in the blood plasma of the level of 10 amino acids, ethanolamine and glutathione. Тritarg in comparison with Tavamin and Neyramin shows the well expressed hepatotrophic effect, normalizing the levels of 9 amino acids and glutathione, and has a more expressed positive influence on metabolic deviations at intermittent alcohol intoxication.
About the Authors
V. V. Lelevich
Grodno State Medical University
Belarus
D. Sc. (Med.), Professor, Head of the Department
Belarus
D. Sc. (Med.), Professor, Head of the Department
S. V. Lelevich
Grodno State Medical University
Belarus
D. Sc. (Med.), Professor
Belarus
D. Sc. (Med.), Professor
References
1. Agibalova T. B., Shustov D. I., Tuchilina O. D. The strategy of decrease in consumption of alcohol as a new opportunity in therapy of alcoholic dependence. Socialnaja i klinicheskaja psichiatrija [Society and Clininical Psichiatry], 2015, no. 3, pp. 61–68. (in Russian).
2. Lelevich S. V. Central and peripheral mechanisms of alcohol and morfine intoxication. Grodno, GRSMU, 2015, 252 p. (in Russian).
3. Lelevich V. V., Vinitskaja A. G., Lelevich S. V. Features of exchange of GABA in a liver of rats at various modes of alcohol withdrawal. Biomedicinskaja Chimija [Biomedical Chemistry], 2014, vol. 5, pp. 561–566. (in Russian).
4. Guan Y., Xiao C., Kmjeviж K., Xie G., Zuo W., Ye J.-H. GABAergic actions mediate opposite ethanol effects on dopa-minergic neurons in the anterior and posterior ventral tegmental. The Journal of Pharmacology and Experimental Therapeutics, 2010, vol. 341, no. 1, pp. 33–42.
5. Lelevich V. V., Artemova O. V. Condition of a pool of free amino acids of blood and liver at chronic alcohol intoxication. Zhurnal GrGMU [Journal of GRSMU], 2010, no. 2, pp. 16–19. (in Russian).
6. Anochina I. P. Biological mechanisms of dependence on psychoactive agents (pathogenesis). Lectures on Narcology. Мoscow, Nauka [Science], 2000, pp. 16–40. (in Russian).
7. Panchenko L. F., Davudov B. V., Terebilina N. N. Oxidizing stress in pathogenesis of an alcohol liver disease. Voprosi narkologii [Narcology questions], 2013, no. 2. pp. 82–91. (in Russian).
8. Kuznetsov E. E., Gorochova V. G., Gorochov A. A., Sergeyeva A. S., Kurilskaya T. E., Pivovarov Yu. I., Runovich A. A. Mikrosomal oxidation in physiological and pathological processes. Bull. VCNC SO RAMN [Bull. of BSNC SO RAMS], 2007, no. 4, pp. 170–180. (in Russian).
9. Ward R., Lallemand F., Witte P. Biochemical and neurotransmitter changes implicated in alcohol – induced brain damage in chronic or «binge drinking» alcohol abuse. Alcohol Alcoholism, 2009, vol. 44, no. 2, pp. 128–135.
10. Karinch A. M., Martin J. H., Vary T. C. Acute and chronic ethanol consumption differentially impact pathways limiting hepatic protein synthesis. Am. J. Physiol. Endocrinol. Metab., 2008, vol. 295, no. 1, pp. 3–9.
11. Lelevich V. V., Lelevich S. V. The current state of modeling in experimental narcology [Electronic Resurces]. Materialy ezegodnoj nauchno-prakticheskoi konferencii «Aktual’nye problemy mediciny» [Materials of an annual scientific and practical conference «Actual problems of medicine»]. Grodno, Grodno State Medical University, 2017, pp. 517–521. (in Russian).
12. Artemova O. V., Lelevich V. V. Free amino acids of a liver of rats in the conditions of faltering alcohol intoxication. Zhurnal Grodnenskogo gosudarstvennogo medicinskogo universiteta [Journal of Grodno State Medical University], 2007, no. 3, pp. 25–28. (in Russian).
13. Lelevich V. V., Lelevich S. V. Way of modeling of faltering alcohol intoxication at a rat in an experiment. Patent BY, no. 14289, 2011. (in Russian).
14. Sheibak V. M. Exchange of free amino acids and KoA at alcohol intoxication. Grodno, Grodnenskii gosudarstvennyi meditsinskii universitet [Grodno State Medical University], 1998. 153 p. (in Russian).
15. Aleynik S. I., Leo M. A., Aleynik M. K. Increased circulating products of lipid peroxidatioan in patients with alcoholic liver disease. Alcoholism: Clinical and Experimental Research, 1958, vol. 22, no. 1, pp. 19–26.
16. Shabanov P. D. Narcology: the management for doctors. Moscow, GOETAR-Media, 2012. 832 p. (in Russian).
17. Kozlovskii A. V., Lelevich V. V., Vinitskaia A. G., Kurbat M. N., Lelevich S. V. Amino acids and their derivatives in correction of metabolic violations at narcologic diseases. Medicinskie novosti [Med. News], 2004, no. 7, pp. 27–33. (in Russian).
18. Razvodovskii Iu. E. Amino acids in pathogenesis and treatment of alcoholism. Narkologiya [Narcology], 2010, no. 6, pp. 88–96. (in Russian).
19. Gavrilov V. B., Mishkorudnaja M. I. Spektrofotometric determination of content of hydroperoxides of lipids in blood plasma. Laboratornoe delo [Laboratory Buissness], 1983, no. 3, pp. 33–36. (in Russian).
20. Kamushnikov V. S. Reference book on clinical laboratory diagnostics. Minsk, Belarus’ [Belarus], 2002, 462 p. (in Russian).
21. Lelevich V. V., Tarasov Y. A., Lelevich S. V. Changes of a pool of free amino acids in plasma of blood and skeletal muscles of rats at faltering alcohol intoxication. Zhurnal Grodnenenskogo gosudarstvennogo meditsinskogo universiteta [Journal of Grodno State Medical University], 2012, no. 2, pp. 24–26. (in Russian).
Review
For citations:
Lelevich V.V., Lelevich S.V. CORRECTION OF METABOLIC DISORDERS DUE TO AMINO ACID COMPOSITIONS AT INTERMITTENT ALCOHOL INTOXICATION. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(3):22-28. (In Russ.)
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