MARKERS OF MYOCARDIAL AND OXIDATIVE STRESS, ENDOTHELIAL DYSFUNCTION, ATHEROTHROMBOSIS AND RHEOLOGICAL INDICES OF BLOOD OF PATIENTS AFTER URGENT CHOLECYSTECTOMY

It was found that proinflamatory markers (leukocytes, high-sensitivity C-reactive protein, interleukin-6) increase for the first day of hospitalization in patients with acute calculous cholecystitis and significantly decrease in one month after cholecystectomy. It was established that the levels of atherothrombotic and endothelial dysfunction markers among the examined patients grow in one month after cholecystectomy. The index of myocardial stress (NTproBNP) did not change in the distant postoperative period. For the first day of hospitalization, the disturbances in the rheological indices of blood in patients with acute calculous cholecystitis were observed, but after cholecystectomy, some rheological indices became worse. Conservative management of patients with acute calculous cholecystitis was accompanied by increasing inflammation biomarkers and atherothrombotic markers concentrations in comparison to patients who underwent urgent cholecystectomy.

markers of inflammation, endothelial dysfunction, atherothrombosis, rheological indices, acute cholecystitis, cholecystectomy

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