EVOLUTION RATE OF THE APC GENE CODING A PROTEIN PREVENTING THE COLORECTAL CANCER DEVELOPMENT
Abstract
The rates of synonymous mutations in Adenomatous polyposis coli (APC) gene varies greatly among different species of animals. APC genes of rodents had been under the influence of mutational GC-pressure that changed its direction to AT-pressure during a more recent period of time. As a result, the probability of synonymous mutation occurrence in the APC gene of rodents is significantly higher than in the homologous human gene. Rodents cannot be considered to be a reliable model for study of colorectal cancer, unlike monkeys.
About the Authors
V. V. Khrustalev
Belarusian State Medical University
Belarus
Assistant Professor, Head of the Department
Belarus
Assistant Professor, Head of the Department
T. A. Khrustaleva
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Senior researcher
Belarus
Senior researcher
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Review
For citations:
Khrustalev V.V., Khrustaleva T.A. EVOLUTION RATE OF THE APC GENE CODING A PROTEIN PREVENTING THE COLORECTAL CANCER DEVELOPMENT. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(2):121-126. (In Russ.)
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