INFLUENCE OF THE SYNTHETIC ANALOG OF THE ARGININE-VASOPRESSIN FRAGMENT ON RAT TRAINING

Arginine-vasopressin comprises an intriguing peptide hormone having a number of additional effects. It influences the efficiency of training and resistance against stress factors. This work reports the results for the influence of the synthetic analog of the arginine-vasopressin fragment, Ac-D-SPRG on the rat training. A given substance mimics a natural tetrapeptide which results from endogenous lysis of arginine-vasopressin. To make this tetrapeptide more stable in physiological conditions, D-serine was introduced in its sequence. The work was carried out on mature male non-linear rats. The substance appeared to have no influence on the training with positive food reinforcement. In a passive avoidance conditioned reaction test, a substance under test had a positive action in high doses. The most significant effect was recorded in a test of a conditioned reaction of active avoidance of pain stimulus. The main target of the analog action is the reaction to a conditioned sound signal. We concluded that the tested analog improves the animal training with regard to exact, differentiated and expressed conditioned stimulus.

training, regulatory peptides, synthetic analog, arginine-vasopressin, rat, positive reinforcement, conditioned signal

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