FACTORS OF GROWTH, ANGIOGENESIS AND INTERCELLULAR ADHESION FOR EVALUATION OF BLADDER CANCER SPREAD
Abstract
The article provides the data on the concentrations of factors of growth, angiogenesis, intercellular adhesion and their receptors (VEGF, EGF, FGF, TNF-α, sICAM, sPECAM, endostatin, р55, р185) in body fluids of stage I–IV bladder cancer patients. 945 cancer patients and 120 clinically healthy individuals were included in the study. Bladder cancer was morphologically verified in all cases. The above-mentioned laboratory indices were evaluated by immunoassay before the beginning of examination or treatment. Results were analyzed using nonparametric statistics. Informative indices for preoperative assessment of tumor invasion (sICAM, VEGF, sPECAM, р55, р185, FGF), the number of tumor foci (р185, sICAM, р55, FGF, TNF-α) and tumor grade (VEGF, р55, sPECAM, sICAM, р185, endostatin) were identified. ROC curves were plotted and AUCs were calculated to assess the diagnostic value of the indices. The sensitivity and specificity of all indices were evaluated.
About the Author
L. A. Derzhavets
N. N. Alexandrov National Cancer Center
Belarus
Ph. D. (Biol.), Head of the Laboratory
Belarus
Ph. D. (Biol.), Head of the Laboratory
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Review
For citations:
Derzhavets L.A. FACTORS OF GROWTH, ANGIOGENESIS AND INTERCELLULAR ADHESION FOR EVALUATION OF BLADDER CANCER SPREAD. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(2):78-88. (In Russ.)
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