CLINICO-FUNCTIONAL AND BIOCHEMICAL ABNORMALITIES IN PATIENTS WITH SYMPTOMATIC EPILEPSY ON THE BACKGROUND OF ANEURYSMS OF CEREBRAL ARTERIES

The aim of the work was to study clinico-electroencephalographic and biochemical disorders, cerebral hemodynamic parameters in the major arteries of the head in patients with symptomatic epilepsy on the background of unruptured cerebral aneurysms. The patients were divided into control (n = 19) and main (n = 11) groups. Various kinds of neurosurgical treatment of aneurysms were performed in 100 % of the patients of the main group and 79 % of the patients of the control group. Changes in the bioelectric activity of the brain were revealed in 22 % of patients with epilepsy on the background of unruptured cerebral aneurysms, who were the patients of the main group. The regional slow-wave activity and the regional epileptiform activity were identified on the side of the aneurysm location in these cases. Preservation of the cognitive function was demonstrated in all patients who were defined with the help of the Mini Mental State Examination scale. No statistically significant changes in a peak systolic blood flow velocity was revealed in the middle cerebral and internal carotid arteries and the Lindegaard index value in the aneurysmal modified and intact vessels when duplex scanning of the major arteries of the head. Disorders of carbohydrate-energy metabolism, imbalance in the pro-, antioxidant system of the blood and the trend to increase the concentration of tumor necrosis factor-alpha were found in the blood biochemical study of patients.

cerebral aneurysms, symptomatic epilepsy, bioelectric activity of brain, cerebral hemodynamic, lipid peroxidation

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