MORPHOLOGICAL AND HISTOCHEMICAL CHARACTERISTICS OF EXOCRINE CELLS OF THE GASTRIC MUCOSA IN CHILDREN WITH CHRONIC GASTRITIS AT THE DYSPLASIA OF THE CONNECTIVE TISSUE
Abstract
The aim of this study was to investigate the activity of succinate dehydrogenase, lactate dehydrogenase, NADH-dehydrogenase, and acid phosphatase in biopsies of the bottom and pyloric parts of the stomach in children (6-18 years of age) with chronic gastritis and chronic gastritis at the dysplasia of the connective tissue. Histological and histochemical methods, morphometry, cytophotometry and statistical analysis were used.
It was found that the connective tissue dysplasia causes destructive changes in simple columnar epithelium, especially in the bottom part, with inhibition of the synthesis of mucopolysaccharides, which leads to a reduction in the number of epithelial cells not only in the simple columnar, but also in the mucus. Changes in the main and, especially, parietal exocrine cells are less pronounced. So, reducing the mucosal barrier in the presence of aggressive factors juice in children with chronic gastritis at the dysplasia of the connective tissue leads to a higher incidence of erosion and sometimes ulcers with increasing disease severity.
It was found that the connective tissue dysplasia causes destructive changes in simple columnar epithelium, especially in the bottom part, with inhibition of the synthesis of mucopolysaccharides, which leads to a reduction in the number of epithelial cells not only in the simple columnar, but also in the mucus. Changes in the main and, especially, parietal exocrine cells are less pronounced. So, reducing the mucosal barrier in the presence of aggressive factors juice in children with chronic gastritis at the dysplasia of the connective tissue leads to a higher incidence of erosion and sometimes ulcers with increasing disease severity.
About the Authors
Ya. R. Matsiuk
Grodno State Medical University
Belarus
D. Sc. (Biol.), Professor
Belarus
D. Sc. (Biol.), Professor
N. S. Paramonava
Grodno State Medical University
Belarus
D. Sc. (Med.), Head of the Department
Belarus
D. Sc. (Med.), Head of the Department
A. A. Karcheuski
Grodno State Medical University
Belarus
Assistant.
Belarus
Assistant.
O. V. Baraban
Grodno State Medical University
Belarus
Ph. D. (Biol.), Associate Professor.
Belarus
Ph. D. (Biol.), Associate Professor.
References
1. Belmer S. V., Khavkin A. I., Shcherbakov P. L. (ed.). Gastroenterologiya detskogo vozrasta [Pediatric gastroenterology], 2nd ed., Medpraktika-M, Mosсow, Russia, 2010.
2. Cam S. “Risk of gastric cancer in children with Helicobacter pylori infection”, Asian Pacific Journal of CancerPrevention, 2014, vol. 22, pp. 9905–9908.
3. Villarreal-Calderon R. “Antral atrophy, intestinal metaplasia, preneoplastic markers in Mexican children withHelicobacter pylori-positive, Helicobacter pylori-negative gastritis”, Annals of Diagnostic Pathology, 2014, vol. 3, pp. 129–135.
4. “Heritable and many-factor disorders of the connective tissue of children: diagnosis algorithms, management”, Zhurnal«Pediatriya» imeni G. N. Speranskogo [Journal “Pediatria” named after G. N. Speransky], 2014, vol. 93. no. 5, pp. 1–40.
5. Trutneva L. A., Chemodanov V. V. “Features of gastroduodenal diseases of children with non-differentiated dysplasiaof the connective tissue”, Zhurnal «Pediatriya» imeni G. N. Speranskogo [Journal “Pediatria” named after G. N. Speransky], 2010, vol. 89, no. 2, pp. 12–17.
6. Milkovska-Dmitrova T. Vrozhdenna soedinitel’no-tkanna malostoikost’ u detsata [Small congential stability of theconnective tissue of children congential stability of the connective tissue of children], Medical, Training, Sofia, BG, 1987.
7. Pirs E. Gistokhimiya teoreticheskaya i prikladnaya [Gystochemistry, theoretical and applied], Inostrannaya literatura,Mosсow, Russia, 962 р.
Review
For citations:
Matsiuk Ya.R., Paramonava N.S., Karcheuski A.A., Baraban O.V. MORPHOLOGICAL AND HISTOCHEMICAL CHARACTERISTICS OF EXOCRINE CELLS OF THE GASTRIC MUCOSA IN CHILDREN WITH CHRONIC GASTRITIS AT THE DYSPLASIA OF THE CONNECTIVE TISSUE. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(1):90-96. (In Russ.)
Views: 457
Email this article 