CORRELATION BETWEEN MOLECULAR-GENETIC CHARACTERISTICS OF MYCOBACTERIUM TUBERCULOSIS AND PREVALENCE, MANIFESTATION AND OUTCOME OF DISEASE

A brief review of the current publications is referred to the analysis of the molecular and genetic characteristics of Mycobacterium tuberculosis and the genetic factors of macroorganism that may influence the susceptibility/resistance
to tuberculosis and thus may affect the prevalence, manifestation, and outcome of tuberculosis. The genotype Beijing plays a key role in the spread of M. tuberculosis with multidrug resistance. Fifty eight percent of M. tuberculosis isolates collected from different regions of Belarus belonged to the genotype Beijing and had an identical MIRU VNTR profile. The resistance to anti-tuberculosis drugs in M. tuberculosis is formed due to mutations in the following genes: to isoniazid – in genes katG, inhA, acpM-kasA), to rifampin – in rpoB, to streptomycin – in rrs, rpsL, to ethambutol – in embB, to ethionamide – in inhA, to pyrazinamide – in pncA, to fluoroquinolones – in gyrA.

genome structure of Mycobacterium tuberculosis, main groups of genes and their functions, macroorganism genetic factors associated with resistance/susceptibility to TB infection, genotypes of Mycobacterium tuberculosis, their geographical distribution, molecular mechanisms of resistance, structure of mutations in genes associated with drug resistance

1. (2015) Global tuberculosis report. WHO: World Health organization, Available at: http://apps.who.int/iris/bitstream/10665/191102/1/9789241565059_eng.pdf?ua=1 (accessed 12 October 2016).

2. Abubakar, I., Zignol, M., Falzon, D., Raviglione, M., Ditiu. L., Masham, S., Adetifa, I., Ford, N., Cox, H., Lawn, S. D., Marais, B. J., McHugh, T. D., Mwaba, P. and Bates, M. (2013) “Drug-resistant tuberculosis: Time for visionary political leadershi”, The Lancet Infectious Diseases, vol. 13, no. 6, pp. 529-539.

3. Zhang, Y., Yew, W. W., Deun, A. Van, Martin A., Palomino, J. C., Caminero, J. A., Schaaf, H. S., London, L., Azzopardi, P., Bennett, C. M., Graham, S. M., Duke, T., Lalloo, U. G. and Anthony, R. M. (2011) “Mechanisms of drug resistance development in Mycobacterium tuberculosis”, International Journal of Tuberculosis and Lung Diseases, vol. 2, no. 1, pp. 7-19.

4. (2015) Tuberkulez s mnozhestvennoi lekarstvennoi ustoichivost’yu v Turkmenistane: rezul’taty obshchenatsional’nogo issledovaniya, 2012–2013 gg. [Multidrug resistant tuberculosis in Turkmenistan: results of a national study, 2012–2013 years], European WHO Regional Office, Copenhagen, DK.

5. Matteelli, A., Migliori, G. B., Cirillo, D., Centis, R., Girard ,E. and Raviglion M. (2007) “Multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis: epidemiology and control”, Expert review of anti-infective therapy, vol. 5, no. 5, pp. 857-871.

6. Timperi, R., Han, L. L., Sloutsky, A., Becerra, M. C., Nardell, E. A., Salazar, J. J. and Smith-Fawzi, M. C. (2005) “Drug resistance profiles of Mycobacterium tuberculosis isolates: five years’ experience and insight into treatment strategies for MDR-TB in Lima, Peru”, The international journal of tuberculosis and lung disease, vol. 9, no. 2, pp. 175-180.

7. Skrahina, A., Hurevich, H., Zalutskaya, A., Sahalchyk, E., Astrauko, A., Van Gemert, W., Hoffner, S., Rusovich, V. and Zignol, M. (2012) “Alarming levels of drug-resistant tuberculosis in Belarus: Results of a survey in Minsk”, European Respiratory Journal, vol. 39, no. 6, pp. 1425-1431.

8. Casali, N., Nikolayevskyy, V., Balabanova, Y., Harris, S. R., Ignatyeva, O., Kontsevaya, I., Corander, J., Bryant, J., Parkhill, J., Nejentsev, S., Horstmann, R. D., Brown, T. and Drobniewski, F. (2014) “Evolution and transmission of drug-resistant tuberculosis in a Russian population”, Nature genetics, vol. 46, no. 3, pp. 279-286.

9. Pardini, M., Iona, E., Varaine, F., Karakozian, H., Arzumanian, H., Brunori, L., Orefici, G., Fattorini, L., Oggioni, M. R., Meacci, F., Trappetti, C., Checchi, F., Bonnet, M. and Andrew, P. W. (2005) “Mycobacterium tuberculosis drug resistance Abkhazia”, Emerging Infectious Diseases, vol. 11, no. 3, pp. 501-503.

10. Migliori, G. B., Sotgiu, G., Lange, C. and Centis R. (2010) “Extensively drug-resistant tuberculosis: Back to the future”, European Respiratory Journal, vol. 36, no. 3, pp. 475-477.

11. Raviglione, M. C. and Uplekar, M. W. (2006) “WHO’s new Stop TB Strategy”, Lancet, vol. 367, pp. 952-955.

12. (2014) “Global Tuberculosis report, 2014”, WHO, Available at: http://apps.who.int/iris/bitstream/10665/137094/ 1/9789241564809_eng.pdf, (accessed 12 October 2016)

13. Lienhardt, C., Glaziou, P., Uplekar, M., Lonnroth, K., Getahun, H. and Raviglione, M. (2012) “Global tuberculosis control: lessons learnt and future prospects”, Nature reviews Microbiology, vol. 10, no. 6, pp. 407-416.

14. (2011) Guidelines for the programmatic management of Multidrug-resistant Tuberculosis, World Health Organization, WHO Press, Geneva, CH.

15. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies. R., Devlin, K., Feltwell, T., Hamlin, S. G. N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M.-A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S. and Barrell, B. G. (1998) “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence”, Nature, vol. 393, pp. 537-544.

16. Umpeleva, T. V. (2014) “Molecular and genetic characteristics of Mycobacterium tuberculosis clinical isolates from patients with tuberculosis in the Urals Federal District of the Russian Federation”, Abstract of Ph.D. dissertation, Microbiology, Federal State Institution “Ural Research Institute Phthisiopulmonology”, Ekaterinburg, RU.

17. Mestre, O., Luo, T., Dos Vultos, T., Kremer, K., Murray, A., Namouchi, A., Jackson, C., Rauzier, J., Bifani, P., Warren, R., Rasolofo, V., Mei, J. and Gao, Q. Gicquel, B. (2011) “Phylogeny of Mycobacterium tuberculosis Beijing strains constructed from Polymorphisms in genes involved in DNA replication, recombination and repair”, PLoS ONE, vol. 6, no. 1, pp. 1-7.

18. Dos Vultos, T., Mestre, O., Rauzier, J., Golec, M., Rastogi, N., Rasolofo, V., Tonjum, T., Sola, C., Matic. I. and Gicquel, B. (2008) “Evolution and diversity of clonal bacteria: The paradigm of Mycobacterium tuberculosis”, PLoS ONE, vol. 3, no. 2, p. e1538.

19. Yang, Z., Rosenthal, M., Rosenberg, N. A., Talarico, S., Zhang, L., Marrs, C., Thomsen, V. O., Lillebaek, T. and Andersen, A. B. (2011) “How dormant is Mycobacterium tuberculosis during latency? A study integrating genomics and molecular epidemiology”, Infection, Genetics and Evolution, vol. 11, no. 5, pp. 1164-1167.

20. Downing, K. J., Mischenko, V. V, Shleeva, M. O., Young, D. I., Young, M., Kaprelyants, A. S., Apt, A. S. and Mizrahi, V. (2005) “Mutants of Mycobacterium tuberculosis Lacking Three of the Five rpf-Like Genes are Defective for Growth in vivo and for Resuscitation in vitro”, Infection and Immunity, vol. 73, no. 5, pp. 3038-3043.

21. Murphy, D. J. and Brown, J. R. (2007) “Identification of gene targets against dormant phase Mycobacterium tuberculosis infections”, BMC infectious diseases, vol. 7, p. 84.

22. Blaser, M. J., Musser, J. M., Bifani, P. J., Kreiswirth, B. N. and Small, P. M. (2001) “The nature and consequence of genetic variability within Mycobacterium tuberculosis”, The Journal of Clinical Investigation, vol. 107, no. 5, pp. 533-537.

23. Curtis, J., Luo, Y., Zenner, H. L., Cuchet-Lourenço, D., Wu C., Lo, K., Maes, M., Alisaac. A., Stebbings, E., Liu, J. Z., Kopanitsa, L., Ignatyeva, O., Balabanova, Y. and Nikolayevskyy, V. (2015) “Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration”, Nature genetics, vol. 47, no. 5, pp. 523-527.

24. Zvonkova, S. G., Ogarkov, O. B. and Zorkal’tsev, E. Y. (2011) “Study of of DC-SIGN -336A / G, MCP1 -2518A / G, INFγ + 874A/T gene polymorphism and constitutional types of children with TB infection”, Byulleten’ VSTsN SO RAMN [VSTSN Bulletin SB RAMS], vol. 2, no. 78, pp. 198-200.

25. Sin’kov, V. V., Ogarkov, O. B., Zhdanova, S. N., Antipina, S. L. and Savilov, E. D. (2011) “Analysis of 336A/G gene DC-SIGN (CD209) polymorphism in the autopsy samples”, Byulleten’ VSTsN SO RAMN [VSTSN Bulletin SB RAMS], vol. 2, no. 78, pp. 220-222.

26. Vasil’eva, N. R., Vyazovaya, A. A., Zhuravleva, V. Y. Solov’eva, N. S., Mokrousov, I. V. and Narvskaya, O. V. (2016) “Genotypes of extended-drug resistant strains of Mycobacterium tuberculosis and clinical and epidemiological features of lung tuberculois”, Infektsiya i Immunitet [Infectiona and Immunity], vol. 6, no. 2, pp. 179-183.

27. Sola, C., Filliol, I., Legrand, E., Lesjean, S., Locht, C., Supply, P. and Rastogi, N. (2003) “Genotyping of the Mycobacterium tuberculosis complex using MIRUs: Association with VNTR and spoligotyping for molecular epidemiology and evolutionary genetics”, Infection, Genetics and Evolution, vol. 3, no. 2, pp. 125-133.

28. Supply, P. (2005) “Multilocus Variable Number Tandem Repeat Genotyping of Mycobacterium tuberculosis. Technical guide. Institut Pasteur de Lille”, Available at: http://www.miru-vntrplus.org/MIRU/miruinfo.faces, (accessed 12 October 2016).

29. Supply, P., Lesjean, S., Savine, E., Kremer, K., Van Soolingen, D. and Locht, C. (2001) “Automated high-throughput genotyping for study of global epidemiology of Mycobacterium tuberculosis based on mycobacterial interspersed repetitive units”, Journal of Clinical Microbiology, vol. 39, no. 10, pp. 3563-3571.

30. (2004) “Guide to the Application of Genotyping to Tuberculosis Prevention and Control. Centers for Disease Control and Prevention, and Advisory Group on Tuberculosis Genotpying”, Available at: http://www.cdc.gov/tb/programs/genotyping/ images/tbgenotypingguide_june2004.pdf, (accessed 12 October 2016).

31. Sankar, M. M., Singh, J., Diana, S. C. A. and Singh, S. (2013) “Molecular characterization of Mycobacterium tuberculosis isolates from North Indian patients with extrapulmonary tuberculosis”. Tuberculosis (Edinburgh, Scotland), vol. 93, no. 1, pp. 75-83.

32. Mokrousov, I. V. (2015) “Molecular structure of Mycobacterium tuberculosis population in Russia and its interaction with neighboring countries”, International Journal of Mycobacteriology, vol. 4, pp. 56-57.

33. Streicher, E. M., Victor, T. C., Van Der Spuy, G., Sola, C., Rastogi, N., Van Helden. P. D. and Warren, R. M. (2007) “Spoligotype signatures in the Mycobacterium tuberculosis complex”, Journal of Clinical Microbiology, vol. 45, no. 1, pp. 237-240.

34. Mokrousov, I. V., Vyazovaya, A. and Narvskaya, O. (2014) “Mycobacterium tuberculosis Latin American-Mediterranean family and its sublineages in the light of robust evolutionary markers”, Journal of Bacteriology, vol. 196, no. 10, pp. 1833-1841.

35. Mokrousov, I. V. (2012) “Methodological approaches to mycobacterium tuberculosis to genotyping for evolutionary research”, Infektsiya i Immunitet [Infection and Immunity], vol. 2, no. 3, pp. 603-614.

36. Wang, J., Liu, Y., Zhang, C. L., Ji, B. Y., Zhang, L. Z., Shao, Y. Z., Jiang, S. L., Suzuki, Y., Nakajima, C., Fan. C. L., Ma, Y. P., Tian, G. W., Hattori. T. and Ling, H. (2011) “Genotypes and characteristics of clustering and drug susceptibility of mycobacterium tuberculosis isolates collected in heilongjiang province, China”, Journal of Clinical Microbiology, vol. 49, no. 4, pp. 1354-1362.

37. Galagan J. E. (2014) “Genomic insights into tuberculosis”, Nature reviews. Genetics, vol. 15, no. 5, pp. 307-320.

38. Mokrousov, I. V., Valcheva, V., Sovhozova, N., Aldashev, A., Rastogi. N. and Isakova, J. (2009) “Penitentiary population of Mycobacterium tuberculosis in Kyrgyzstan: Exceptionally high prevalence of the Beijing genotype and its Russia-specific subtype”, Infection, Genetics and Evolution, vol. 9, no. 6, pp. 1400-1405.

39. Niemann, S., Diel, R., Khechinashvili, G., Gegia, M., Mdivani, N. and Tang, Y. W. (2010) “Mycobacterium tuberculosis Beijing lineage favors the spread of multidrug-resistant tuberculosis in the Republic of Georgia”, Journal of Clinical Microbiology, vol. 48, no. 10, pp. 3544-3550.

40. Surikova, O. V., Voitech, D. S., Kuzmicheva, G., Tatkov, S. I., Mokrousov, I. V., Narvskaya, O. V., Rot, M. A., Van Soolingen, D. and Filipenko, M. L. (2005) “Efficient differentiation of Mycobacterium tuberculosis strains of the W-Beijing family from Russia using highly polymorphic VNTR loci”, European Journal of Epidemiology, vol. 20, no. 11, pp. 963-974.

41. Chernyaeva, E., Dobrynin, P., Pestova, N., Matveeva, N., Zhemkov, V. and Kozlov, A. (2012) “Molecular genetic analysis of Mycobacterium tuberculosis strains spread in different patient groups in St. Petersburg, Russia”, European Journal of Clinical Microbiology and Infectious Diseases, vol. 31, no. 8, pp. 1753-1757.

42. Isaeva, T. H. (2012) “Disease course and effectiveness of the treatment of patients newly diagnosed pulmonary tuberculosis depending on the genotype of M. tuberculosis”, Abstract of Ph.D. dissertation, phthisiatry, Central Research Institute of Tuberculosis, Мoscow, RU.

43. Savilov, E. D., Sinkov, V. V. and Ogarkov, O. B. (2011) “Reconstructing the history of genotype “Beijing” spread in the Russia and Post-Soviet countries by molecular biology techniques”, Byulleten’ VSTsN SO RAMN [VSTSN Bulletin SB RAMS], vol. 2, no. 78, pp. 172-175.

44. Blaser, M. J., Musser, J. M., Bifani, P. J., Kreiswirth, B. N. and Small, P. M. (2001) “The nature and consequence of genetic variability within Mycobacterium tuberculosis”, The Journal of Clinical Investigation, vol. 107, no. 5, pp. 533-537.

45. Curtis, J., Luo, Y., Zenner, H. L., Cuchet-Lourenço, D., Wu C., Lo, K., Maes, M., Alisaac. A., Stebbings, E., Liu, J. Z., Kopanitsa, L., Ignatyeva, O., Balabanova, Y. and Nikolayevskyy, V. (2015) “Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration”, Nature genetics, vol. 47, no. 5, pp. 523-527.

46. Zvonkova, S. G., Ogarkov, O. B. and Zorkal’tsev, E. Y. (2011) “Study of of DC-SIGN -336A / G, MCP1 -2518A /G, INFγ + 874A/T gene polymorphism and constitutional types of children with TB infection”, Byulleten’ VSTsN SO RAMN [VSTSN Bulletin SB RAMS], vol. 2, no. 78, pp. 198-200.

47. Sin’kov, V. V., Ogarkov, O. B., Zhdanova, S. N., Antipina, S. L. and Savilov, E. D. (2011) “Analysis of 336A/G gene DC-SIGN (CD209) polymorphism in the autopsy samples”, Byulleten’ VSTsN SO RAMN [VSTSN Bulletin SB RAMS], vol. 2, no. 78, pp. 220-222.

48. Vasil’eva, N. R., Vyazovaya, A. A., Zhuravleva, V. Y. Solov’eva, N. S., Mokrousov, I. V. and Narvskaya, O. V. (2016) “Genotypes of extended-drug resistant strains of Mycobacterium tuberculosis and clinical and epidemiological features of lung tuberculois”, Infektsiya i Immunitet [Infectiona and Immunity], vol. 6, no. 2, pp. 179-183.

49. Sola, C., Filliol, I., Legrand, E., Lesjean, S., Locht, C., Supply, P. and Rastogi, N. (2003) “Genotyping of the Mycobacterium tuberculosis complex using MIRUs: Association with VNTR and spoligotyping for molecular epidemiology and evolutionary genetics”, Infection, Genetics and Evolution, vol. 3, no. 2, pp. 125-133.

50. Supply, P. (2005) “Multilocus Variable Number Tandem Repeat Genotyping of Mycobacterium tuberculosis. Technical guide. Institut Pasteur de Lille”, Available at: http://www.miru-vntrplus.org/MIRU/miruinfo.faces, (accessed 12 October 2016).

51. Supply, P., Lesjean, S., Savine, E., Kremer, K., Van Soolingen, D. and Locht, C. (2001) “Automated high-throughput genotyping for study of global epidemiology of Mycobacterium tuberculosis based on mycobacterial interspersed repetitive units”, Journal of Clinical Microbiology, vol. 39, no. 10, pp. 3563-3571.

52. (2004) “Guide to the Application of Genotyping to Tuberculosis Prevention and Control. Centers for Disease Control and Prevention, and Advisory Group on Tuberculosis Genotpying”, Available at: http://www.cdc.gov/tb/programs/genotyping/ images/tbgenotypingguide_june2004.pdf, (accessed 12 October 2016).

53. Sankar, M. M., Singh, J., Diana, S. C. A. and Singh, S. (2013) “Molecular characterization of Mycobacterium tuberculosis isolates from North Indian patients with extrapulmonary tuberculosis”. Tuberculosis (Edinburgh, Scotland), vol. 93, no. 1, pp. 75-83.

54. Mokrousov, I. V. (2015) “Molecular structure of Mycobacterium tuberculosis population in Russia and its interaction with neighboring countries”, International Journal of Mycobacteriology, vol. 4, pp. 56-57.

55. Streicher, E. M., Victor, T. C., Van Der Spuy, G., Sola, C., Rastogi, N., Van Helden. P. D. and Warren, R. M. (2007) “Spoligotype signatures in the Mycobacterium tuberculosis complex”, Journal of Clinical Microbiology, vol. 45, no. 1, pp. 237-240.

56. Mokrousov, I. V., Vyazovaya, A. and Narvskaya, O. (2014) “Mycobacterium tuberculosis Latin American-Mediterranean family and its sublineages in the light of robust evolutionary markers”, Journal of Bacteriology, vol. 196, no. 10, pp. 1833-1841.

57. Mokrousov, I. V. (2012) “Methodological approaches to mycobacterium tuberculosis to genotyping for evolutionary research”, Infektsiya i Immunitet [Infection and Immunity], vol. 2, no. 3, pp. 603-614.

58. Wang, J., Liu, Y., Zhang, C. L., Ji, B. Y., Zhang, L. Z., Shao, Y. Z., Jiang, S. L., Suzuki, Y., Nakajima, C., Fan. C. L., Ma, Y. P., Tian, G. W., Hattori. T. and Ling, H. (2011) “Genotypes and characteristics of clustering and drug susceptibility of mycobacterium tuberculosis isolates collected in heilongjiang province, China”, Journal of Clinical Microbiology, vol. 49, no. 4, pp. 1354-1362.

59. Galagan J. E. (2014) “Genomic insights into tuberculosis”, Nature reviews. Genetics, vol. 15, no. 5, pp. 307-320.

60. Mokrousov, I. V., Valcheva, V., Sovhozova, N., Aldashev, A., Rastogi. N. and Isakova, J. (2009) “Penitentiary population of Mycobacterium tuberculosis in Kyrgyzstan: Exceptionally high prevalence of the Beijing genotype and its Russia-specific subtype”, Infection, Genetics and Evolution, vol. 9, no. 6, pp. 1400-1405.

61. Niemann, S., Diel, R., Khechinashvili, G., Gegia, M., Mdivani, N. and Tang, Y. W. (2010) “Mycobacterium tuberculosis Beijing lineage favors the spread of multidrug-resistant tuberculosis in the Republic of Georgia”, Journal of Clinical Microbiology, vol. 48, no. 10, pp. 3544-3550.

62. Surikova, O. V., Voitech, D. S., Kuzmicheva, G., Tatkov, S. I., Mokrousov, I. V., Narvskaya, O. V., Rot, M. A., Van Soolingen, D. and Filipenko, M. L. (2005) “Efficient differentiation of Mycobacterium tuberculosis strains of the W-Beijing family from Russia using highly polymorphic VNTR loci”, European Journal of Epidemiology, vol. 20, no. 11, pp. 963-974.

63. Chernyaeva, E., Dobrynin, P., Pestova, N., Matveeva, N., Zhemkov, V. and Kozlov, A. (2012) “Molecular genetic analysis of Mycobacterium tuberculosis strains spread in different patient groups in St. Petersburg, Russia”, European Journal of Clinical Microbiology and Infectious Diseases, vol. 31, no. 8, pp. 1753-1757.

64. Isaeva, T. H. (2012) “Disease course and effectiveness of the treatment of patients newly diagnosed pulmonary tuberculosis depending on the genotype of M. tuberculosis”, Abstract of Ph.D. dissertation, phthisiatry, Central Research Institute of Tuberculosis, Мoscow, RU.

65. Savilov, E. D., Sinkov, V. V. and Ogarkov, O. B. (2011) “Reconstructing the history of genotype “Beijing” spread in the Russia and Post-Soviet countries by molecular biology techniques”, Byulleten’ VSTsN SO RAMN [VSTSN Bulletin SB RAMS], vol. 2, no. 78, pp. 172-175.

66. Savilov, E. D., Sinkov, V. V. and Ogarkov, O. B. (2012) Epidemiologiya tuberkuleza na Evro-Aziatskom kontinente. Otsenka global’nogo dvizheniya shtammov genotipa “Pekin” [Epidemiology of tuberculosis in Euro-Asian continent. Evaluation of the global spread of genotype “Beijing” strains], IGM APO, Irkutsk, RU.

67. Otten, T. F., Vasilyev, S. N., Manicheva, O. A. and Mokrousov, I. V. (2003) “Pulmonary Tuberculosis, caused by different genotypes of Mycobacterium tuberculosis”, Problemy tuberkuleza [Tuberculosis Problems], vol. 10, pp. 13-15.

68. López, B., Aguilar, D., Orozco, H., Burger, M., Espitia. C., Ritacco, V., Barrera, L., Kremer, K., Hernandez-Pando R., Huygen, K. and Van Soolingen, D. (2003) “A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes”, Clinical and Experimental Immunology, vol. 133, no. 1, pp. 30-37.

69. Skvortsova, L. A., Pavlova, M. V., Sapozhnikova, N. V., Vishnevskii, B. K. and Narvskaya, O. V. (2005) “Tuberculosis today: characteristics of the pathogen, clinical course and treatment”, Problemy tuberkuleza i bolezni legkikh [Problems of Tuberculosis and Lung Disease], no. 11, pp. 6-10.

70. Tsolaki, A. G., Gagneux, S., Pym, A. S., Salmoniere, Y. L. G., De Barry, N., Soolingen, D. Van, Small, P. M. and Kreiswirth, B. N. (2005) “Genomic Deletions Classify the Beijing/W Strains as a Distinct Genetic Lineage of Mycobacterium tuberculosis”, Journal of Clinical Microbiology, vol. 43, no. 7, pp. 3185-3191.

71. Rivera-Ordaz, A., Gonzaga-Bernachi, J., Serafín-López, J., Hernández-Pando, R., Van Soolingen, D., Estrada-Parra, S. Estrada-García I. and Chacón-Salinas, R. (2012) “Mycobacterium tuberculosis Beijing genotype induces differential cytokine production by peripheral blood mononuclear cells of healthy BCG vaccinated individuals”, Immunological investigations, vol. 41, no. 2, pp. 144-156.

72. Bifani, P. J., Mathema, B., Kurepina, N. E. and Kreiswirth, B. N. (2002) “Global dissemination of the Mycobacterium tuberculosis W-Beijing family strains”, Trends in Microbiology, vol. 10, no. 1, pp. 45-52.

73. Balasanyants, G. S., Isaeva, N. Y. and Grishko, A. N. (2011) “Surveillance of the genetic affiliation of Mycobacterium tuberculosis in several areas of North-West Russia”, Tuberkulez i bolezni legkikh: materialy IX s’ezda ftiziatrov Rossii [Tuberculosis and Lung Disease: Proceedings of the IX Congress of Russian TB doctors], vol. 88, no. 4, рp. 47-48.

74. Isaeva, T. H. (2012). “Features of a current the аcute progressing of forms of a pulmonary tuberculosis depending on a genotype of M. tuberculosis”, Infektsionnye bolezni [Infectious diseases], vol. 10, no. 3, pp. 98-99.

75. Skornyakov, S. N., Umpeleva, T. V, Vyazovaya, A. A., Kravchenko, M. A., Eremeeva, N. I. and Narvskaya, O. V. (2014) “Genotyping of isolates Mycobacterium tuberculosis from Ural”, Biologicheskie nauki [Biological sciences], vol. 9, pp. 2485-2488.

76. Chernousova, L. N., Andreewskaya, S. N., Smirnova, T., Zemskova, Z. S. and Larionova, E. E. (2008) “Biological properties of cluster W M. tuberculosis strains”, Problemy tuberkuleza i bolezni legkikh [Problems of Tuberculosis and Lung Disease], vol.10, pp. 45-50.

77. Chernousova, L. N., Kryvonos, P. S. and Andreewskaya, S. N. (2001) “Molecular epidemiology of tuberculosis in prisons”, Aktual’nye problemy penitentsiarnoi meditsiny: materialy mezhdunarodnoi nauchno-prakticheskoi konferentsii [Problems of Penitentiary Medicine: Proceedings of the international. scientific. pract. conference], Minsk, BY, p. 48.

78. Slizen, V. V., Surkova, L. K. and Zalutskaya, O. M. (2015) “Analysis of the results of the study genotype Mycobacterium tuberculosis drug resistance”, Meditsinskaya panorama [Medical panorama], vol. 9, no. 162, pp. 46-51.

79. Vasilenko, N. V., Vyazovaya, A. A., Mokrousov, I. V., Lemeschenko, E. V. and Smenov, V. N. (2006) “Spoligotyping of drug-resistant strains of Mycobacterium tuberculosis, circulating in Belarus”, Immunologiya, allergologiya, infektologiya [Immunology, allergology, infectology], no. 4, pp. 70-74.

80. Titov, L. P., Zakerbostanabad, S., Slizen, V., Surkova, L., Taghikhani, M. and Bahrmand, A. (2006) “Molecular characterization of rpoB gene mutations in rifampicine-resistant Mycobacterium tuberculosis isolates from tuberculosis patients in Belarus”, Biotechnology Journal, vol. 1, no. 12, pp. 1447-1452.

81. Zaker, Bostanabad, S., Titov, L. P., Slizen, V. V., Taghikhani, M. and Bahrmand, A. (2007) “KatG mutations in isoniazidresistant strains of Mycobacterium tuberculosis isolates from Belarusian patients”, Tuberkuloz ve Toraks, vol. 55, no. 3, pp. 231-237.

82. Brennan, P. J., Brosch, R., Birren, B. and Sobral, B. (2013) “TBCAP. Tuberculosis annotation project”, Tuberculosis, 2013, vol. 93, no. 1, pp. 1-5.