ASSESSMENT OF ANTINOCICEPTIVE EFFECTS OF PALMITIC ACID AMIDES
Abstract
The effect of some amides of palmitic acid on the pain sensitivity was studied on rats using different tests of the pain response. Single injections (2.5 μmol/kg) of N-palmitoylglycine, N-palmitoylserinol, and N-palmitoyl-5-aminolevulinic acid were found to decrease the pain threshold in varying degrees both during thermal and mechanical stimuli submission. The data suggest that the amides mentioned above can take an important part in pain sensation presumable through the lipid signaling.
About the Authors
T. V. Melik-Kasumov
Institute of Physiology of the National Academy of Sciences of Belarus
Russian Federation
Ph. D. (Biol.), Senior Researcher of the laboratory of body function modulation
Russian Federation
Ph. D. (Biol.), Senior Researcher of the laboratory of body function modulation
T. O. Pavlut
Institute of Physiology of the National Academy of Sciences of Belarus
Russian Federation
Researcher of the laboratory of body function modulation
Russian Federation
Researcher of the laboratory of body function modulation
I. P. Zhavoronok
Institute of Physiology of the National Academy of Sciences of Belarus
Russian Federation
Ph. D. (Biol.), Researcher of the laboratory of body function modulation
Russian Federation
Ph. D. (Biol.), Researcher of the laboratory of body function modulation
O. A. Antipova
Institute of Physiology of the National Academy of Sciences of Belarus
Russian Federation
Junior Researcher of the laboratory of body function modulation
Russian Federation
Junior Researcher of the laboratory of body function modulation
E. I. Pehtereva
Institute of Physiology of the National Academy of Sciences of Belarus
Russian Federation
Junior Researcher of the laboratory of body function modulation
Russian Federation
Junior Researcher of the laboratory of body function modulation
A. I. Vasilkevich
Institute of Physiology of the National Academy of Sciences of Belarus
Russian Federation
Researcher of the laboratory of lipid chemistry
Russian Federation
Researcher of the laboratory of lipid chemistry
M. A. Kisel
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Russian Federation
D. Sc. (Chem.), Head of the laboratory of lipid chemistry
Russian Federation
D. Sc. (Chem.), Head of the laboratory of lipid chemistry
A. Yu. Molchanova
Institute of Physiology of the National Academy of Sciences of Belarus
Russian Federation
Ph. D., Head of the laboratory of body function modulation
Russian Federation
Ph. D., Head of the laboratory of body function modulation
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Review
For citations:
Melik-Kasumov T.V., Pavlut T.O., Zhavoronok I.P., Antipova O.A., Pehtereva E.I., Vasilkevich A.I., Kisel M.A., Molchanova A.Yu. ASSESSMENT OF ANTINOCICEPTIVE EFFECTS OF PALMITIC ACID AMIDES. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2016;(4):25-31. (In Russ.)
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