PROTEIN TYROSINE PHOSPHATASE IN THE PREDICTION OF PERITONEAL DISSEMINATION IN PATIENTS WITH RESECTABLE GASTRIC CANCER
Abstract
The expression level of the protein tyrosine phosphatase gene (PRL-3) in the primary tumor and parietal peritoneum of 52 radically operated gastric cancer patients was investigated. The threshold value of PRL-3 to predict the peritoneal dissemination after surgical treatment was defined.
About the Authors
M. Yu. REUTOVICH
N. N. Alexandrov National Cancer Center of Belarus
Belarus
Belarus
A. I. SHMAK
N. N. Alexandrov National Cancer Center of Belarus
Belarus
Belarus
O. V. KRASKO
United Institute of Informatics Problems of the National Academy of Sciences of Belarus
Belarus
Belarus
R. M. SMOLYAKOVA
N. N. Alexandrov National Cancer Center of Belarus
Belarus
Belarus
References
1. Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer / N. Dai [et al.] // World J. Gastroenterol. – 2009. – Vol. 15, N 12. – P. 1499–1505.
2. Prognosis of рhosphatase of regenerating liver 3 expression in gastric cancer: a meta- analysis / L. Hu [et al.] // PLoS ONE. – 2013. – Vol. 8 (10): e76927. doi: 10.1371/Journal pone.0076927.
3. Al-Aidaroos, A. Q. PRL-3 phosphatase and cancer metastasis / A. Q. Al-Aidaroos, Q. Zeng // J. Cell. Biochem. – 2010. – Vol. 111. – Р. 1087–1098.
4. Prognostic value of PRL-3 overexpression in early stages of colonic cancer / X. Xing [et al.] // Histopathology. – 2009. – Vol. 54. – Р. 309–318.
5. PTP4A3 (PRL-3) expression correlate with lymphatic metastases in gastric cancer / A. Pryczynicz [et al.] // Folia Histochem. Cytobiol. – 2010. – Vol. 48, N 4. – Р. 632–636.
6. High PRL-3 expression in human gastric cancer is a marker of metastasis and grades of malignancies: an in situ hybridization study / U. A. Miskad [et al.] // Virchows Arch. – 2007. – Vol. 450, N 3. – P. 303–310.
7. Association of tyrosine PRL-3 phosphatase protein expression with peritoneal metastasis of gastric carcinoma and prognosis / Z. R. Li [et al.] // Surg. Today. – 2007. – Vol. 37. – Р. 646– 651.
8. Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells / F. Unn-Merete [et al.] // Blood. – 2008. – Vol. 111, N 2. – Р. 806–815.
9. Standardized determination of real-time PCR efficiency from a single reaction set-up / A. Tichopad [et al.] // Nucl. Acids Res. – 2003. – Vol. 31, N 20. – e122. doi: 10.1093/nar/gng122.
10. Application of housekeeping npcRNAs for quantitative expression analysis of human transcriptome by real-time PCR / Ch. R. Galiveti [et al.] // RNA. – 2010. – Vol. 16, N 2. – Р. 450–461.
11. Assessment of оptimally selected prognostic factors / B. Lausen [et al.] // Biometr. J. – 2004. – Vol. 46, N 3. – Р. 364– 374.
12. Therneau, T. A рackage for survival analysis in S_ version 2.38 [Электронный ресурс] / T. Therneau. – 2015. – Mode of access: http://CRAN.R-project.org/package=survival>. – Date of access: 12.02.2016.
13. Andersen, P. Cox’s regression model for counting processes, a large sample study / P. Andersen, R. Gill // Annals of Statistics. – 1982. – Vol. 10. – Р. 1100–1120.
14. Hothorn, T. Maxstat: maximally selected rank statistics. R package version 0.7-22 [Электронный ресурс] / T. Hothorn. – 2015. – Mode of access: http://CRAN.R- project.org/package=maxstat. – Date of access: 18.02.2016.
15. Mechanisms of peritoneal metastasis after operation for non-serosa invasive gastric carcinoma: an ultrarapid detection system for intraperitoneal free cancer cells and a prophylactic strategy for peritoneal metastasis / T. Marutsuka [et al.] // Clin. Cancer Res. – 2003. – Vol. 9. – P. 678–685.
16. Peritoneal washing cytology: prognostic value of positive findings in patients with gastric carcinoma undergoing a potentially curative resection / Y. Kodera [et al.] // J. Surg. Oncol. – 1999. – Vol. 72. – P. 60–65.
17. Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer / A. Ooki [et al.] // Oncol. Reports. – 2009. – Vol. 21. – P. 1467–1475.
18. Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis / Z. Li [et al.] // Biochem. Biophys. Res. Commun. – 2006. – Vol. 348. – P. 229–237.
19. Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells / X. Wu [et al.] // Am. J. Pathol. – 2004. – Vol. 164, N 6. – P. 2039–2054.
Review
For citations:
REUTOVICH M.Yu., SHMAK A.I., KRASKO O.V., SMOLYAKOVA R.M. PROTEIN TYROSINE PHOSPHATASE IN THE PREDICTION OF PERITONEAL DISSEMINATION IN PATIENTS WITH RESECTABLE GASTRIC CANCER. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2016;(3):28-34. (In Russ.)
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