PERIPHERAL BLOOD DENDRITIC CELLS, MONOCYTES, MYELOID-DERIVED SUPRESSOR CELLS IN PATIENTS WITH ACUTE EBV-INFECTION

In the current investigation the relative and absolute count of minor leukocyte subsets was assayed: CD1c⁺ and CD141⁺ myeloid dendritic cells, CD14⁺/CD16⁺ blood monocytes, monocytic and granulocytic (CD15⁺ and CD33⁺) myeloid-derived suppressor cells in 33 patients with infectious mononucleosis compared with healthy controls. In patients with infectious mononucleosis the statistically significant myeloid dendritic cell subset redistribution was determined with the increase of CD141⁺ cells, indicative of its role in the immunopathogenesis of the disease. The decrease of the plasmacytoid dendritic cell count in patients with mononucleosis was observed, suggesting the migration to the lymphoid tissue or the selective depletion. The CD15⁺ myeloid suppressor cells count was increased, which decreased the antiviral immunity and at the same time, possibly prevented an excessive T-cell proliferation. The monocytic myeloid-derived suppressor cell count was reduced, explaining the EBV-induced immune system hyperstimulation. Thus it was established that patients with infectious mononucleosis exhibited diverse changes in the content of the minor leukocyte subsets, thus indicating a marked imbalance between pro- and anti-inflammatory immunity factors.

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