Role of the cholinergic system of the brain stem in postural and autonomy disturbances in Parkinson’s disease
Abstract
The article presents an overview of the recent data on the role of an imbalance between cholinergic and dopaminergic neurotransmission in the development of locomotor and autonomic disorders that accompany Parkinson's disease. Particular attention is paid to a selective role of different subtypes of muscarinic and nicotinic receptors in the allocation of dopamine dopaminergic neurons. Among different subtypes (α7, α6, α4 and β2) of nicotinic cholinergic receptors, of the greatest interest is α7-subunit involved in reducing L-DOPA-induced dyskinesias. Therefore, drugs with their target one or more subtypes of n-cholinergic receptors may be optimal for the modulation induced by chronic administration of L-DOPA dyskinesias.
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Role of the cholinergic system of the brain stem in postural and autonomy disturbances in Parkinson’s disease. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2015;(1):103-109. (In Russ.)
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