Effects of clonidine applied on the nasal mucosa of anesthetized rats
Abstract
Alpha2-adrenergic agonist clonidine and its antihypertensive effects are widely used in experimental studies of neu-rotransmitter systems. The aim of this work was to study the characteristics of the electrical activity in the caudal part of the brain stem after the application of clonidine on the nasal mucosa of the rat. Multicellular electrical activity of neurons was recorded in the nucleus of the solitary tract in animals anesthetized by nembutal-urethane. After the application of 50 mkl of 0.1 % clonidine on the nasal mucosa after a 1 min increase in the activity of neurons of the nucleus of the solitary tract was marked from 55 to 112 pulses/s. The phenomenon of anesthesia recovery was discovered after the application of clonidine and hypothetically due to an increase in the previous electrical activity in the brain stem.
About the Authors
D. P. Tokalchik
Институт физиологии НАН Беларуси
Belarus
Belarus
Zh. A. Hladkova
Институт физиологии НАН Беларуси
Belarus
Belarus
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Review
For citations:
Tokalchik D.P., Hladkova Zh.A. Effects of clonidine applied on the nasal mucosa of anesthetized rats. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2015;(2):86-88. (In Russ.)
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