Control of respiratory reactions by ventral medulla structures in apnea modeling
Abstract
In acute experiments on rats, the study of sleep apnea mechanisms has found that the functional heterogeneity of the structures of the ventral medulla is the basis for the implementation of countervailing effects of hypercapnic stimulus in vivo and for the modeling of the functional failure of these structures (with lidocaine). The blockade of structures of caudal parts of the ventral medulla is accompanied by the activation of the electrical activity of the diaphragm due to the "disinhi-bition" in these conditions of neurons of rostral parts of the ventral medulla. Inhibition of the functions of structures of rostral parts of the ventral medulla is accompanied by an irreversible violation of the electrical activity of the diaphragm and respiratory arrest.
References
1. Montesi S. B, Bakker J. P., Macdonald M. et al. // J. Clin. Sleep Med. 2013. Vol. 9, N 11. P. 1187-1191.
2. Chamberlin N. L. // Curr. Opin. Neurobiol. 2013. Vol. 23, N 5. P. 774-779.
3. Колядич Ж., Андрианова Т. Д., Семёник Т. А. и др. // Оториноларингология. Восточная Европа. 2013. № 2 (11). С. 5-15.
4. Колядич Ж. В., Семёник Т. А., Андрианова Т. Д. и др. // Оториноларингология. Восточная Европа. 2013. № 3 (12). С. 63-75.
5. Urfy M. Z,, Suarez J. I. // Handb. Clin. Neurol. 2014. Vol. 119. P. 241-250.
6. Nattie E., Li A. // Compr. Physiol. 2012. Vol. 2, N 1. P. 221-254.
7. Ott M. M., Nuding S. C., Segers L. S. et al. // J. Neurophysiol. 2011. Vol. 105, N 6. P. 2960-2975.
8. Okada Y., Kuwana S., Chen Z. et al. // Adv. Exp. Med. Biol. 2009. Vol. 648. P. 377-385.
9. Xie A., Bedekar A., Skatrud J. B. et al. // Sleep. 2011. Vol. 34, N 6. P. 745-750.
Review
For citations:
Semenik T. Control of respiratory reactions by ventral medulla structures in apnea modeling. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2015;(2):79-82. (In Russ.)
Views: 304
Email this article 