Ultrastructural changes in the chlorinated carbon-induced liver cirrhosis under the influence of photodynamic therapy
Abstract
. Photodynamic therapy of the liver with Photolon was used to test groups of animals. Electron microscopy of liver tissues was performed. The developed method of photodynamic therapy for liver cirrhosis resulted in a significant reduction in the severity of alternative changes of hepatocytes and lipid infiltration, promoted the activation of biosynthetic processes of the liver. Hyperplasia of the smooth endoplasmic reticulum, lysosomes, and macrophages with signs of high phagocytic activity testified to the activation of protective systems of cells in response to residual effects of the pathogenic factor. Ito cells were mainly in a passive state, indicating a positive influence on the course of collagen formation processes. The study of the results of photodynamic therapy seems to be promising in clinical conditions in patients with liver cirrhosis.
About the Authors
E. V. Mahiliavets
Гродненский государственный медицинский университет
Belarus
Belarus
P. V. Garelik
Гродненский государственный медицинский университет
Belarus
Belarus
R. I. Kravchuk
Гродненский государственный медицинский университет
Belarus
Belarus
S. S. Anufrik
Гродненский государственный университет имени Янки Купалы
Belarus
Belarus
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Review
For citations:
Mahiliavets E.V., Garelik P.V., Kravchuk R.I., Anufrik S.S. Ultrastructural changes in the chlorinated carbon-induced liver cirrhosis under the influence of photodynamic therapy. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2015;(2):62-67. (In Russ.)
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