The efficiency of treatment of patients with trifacial neuralgia

Abstract

The main aim of the work was to study clinical and biochemical impairments and to assess complex treatment results of patients with trifacial neuralgia (TN). 23 patients were included in the study. They were divided into the main group - the group of differentiated high-frequency rhizotomy + basic therapy + intravenous laser irradiation of blood (ILIB) + ОАВА-ergic drug Phenibut. The control group was differentiated high-frequency rhizotomy + basic therapy. Besides, 22 almost healthy volunteers were included in the study. Clinical status, indicators of carbohydrate metabolism, lipid peroxidation, antioxidant blood enzymes activity, contents of substance P and noradrenalin in plasma were studied at the beginning of hospitalization and at the end of the treatment course. A significant regress of the pain syndrome was achieved in the both groups. The reactions of lipid peroxidation were normalized while indicators of carbohydrate metabolism were impaired in hypoxic character. An additional prescription of ILIB and Phenibut to patients with TN assisted in the blood contents normalization of the substance P.