Ratio of expression of the Bcl-2 and Bax proteins in the atherosclerotic coronary artery wall
Abstract
The immunohistochemical study of atherosclerotic coronary arteries, taken from the dead with coronary heart disease, found that the early stages of atherogenic lesions are characterized by the dominated expression of proapoptotic Bax protein that promotes the activation of apoptotic cell death. With the progression of atherosclerosis, the expression of anti-apoptotic factor Bcl-2 increases, which is a negative factor leading to the progression and destabilization of atheromatous lesions.
About the Authors
T. E. Vladimirskaya
Belarusian Medical Academy of Postgraduate Education
Belarus
Belarus
I. A. Shved
Belarusian Medical Academy of Postgraduate Education
Belarus
Belarus
Yu. E. Demidchik
Belarusian Medical Academy of Postgraduate Education
Belarus
Belarus
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Review
For citations:
Vladimirskaya T.E., Shved I.A., Demidchik Yu.E. Ratio of expression of the Bcl-2 and Bax proteins in the atherosclerotic coronary artery wall. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2015;(4):51-55. (In Russ.)
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