Soluble tumor necrosis factor receptor-1 as a diagnostic marker of the acute graft-versus-host disease in children after the hemopoietic stem cell transplantation
Abstract
We investigated a diagnostic value of plasma levels of soluble tumor necrosis factor receptor-1 (sTNFR1) and interleukin-8 (IL-8) in children after the hemopoietic stem cell transplantation as biomarkers for acute graft-versus-host disease (GVHD). The results showed that the level IL-8 had no diagnostic value for acute GVHD. We identified that the plasma level of sTNFR1 in patients with acute GVHD increased more than twice as compared to the level before conditioning (р = 0.0005), while in patients without GVHD the level of sTNFR1 did not change significantly. The definition of sTNFR1 can be used for the clinical management of patients undergoing the hemopoietic stem cell transplantation to confirm the diagnosis of acute GVHD.
For citations:
Doroshenko T.M., Akalovich S.T., Bakerava V.A., Avtonomova E.N., Shman T.V., Mareika Y.E., Nevmerzhitskaya A.S., Minakovskaya N.V., Belevtsev M.V., Aleinikova O.V., Voitenok N.N. Soluble tumor necrosis factor receptor-1 as a diagnostic marker of the acute graft-versus-host disease in children after the hemopoietic stem cell transplantation. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2014;(1):69-74. (In Russ.)
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