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Age-related morphological and functional characteristics of tissue basophils of the mucosal membrane of the rat's duodenal developing during cholestasis

Abstract

The experiment with 48 (15-, 45- and 90-day) rat pups using the histological, morphometrical, and statistical investigation methods has shown that the rats, which have developed in the conditions of maternal experimental obturational cholestasis, have a delay in the development of the mucosal membrane structures in the rat's duodenal accompanied by increasing the number and functional activity of tissue basophils in comparison to the control. The last fact points to their participation in the development of adaptive and compensatory mechanisms in response to endogenous intoxication with cholestasis products, as well as the increased functional activity of the organ due to the transition from milk to definitive food.

About the Authors

Ya. R. Matsyuk
Гродненский государственный медицинский университет
Belarus


Y. N. Chernyshevich
Гродненский государственный медицинский университет
Belarus


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Review

For citations:


Matsyuk Ya.R., Chernyshevich Y.N. Age-related morphological and functional characteristics of tissue basophils of the mucosal membrane of the rat's duodenal developing during cholestasis. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2014;(1):63-68. (In Russ.)

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ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)