A new experimental model of chronic pulpitis
https://doi.org/10.29235/1814-6023-2025-22-3-239-245
Abstract
In the specialized literature there are some reports containing information about experimental studies in chronic pulpitis. In one part of them, extracted human teeth are regarded as a variant of the experimental model. In another part, either highly organized animals (dogs) or rodents, whose incisors are constantly growing, were used as a biological object. This does not allow for full reproduction of the clinical situation of chronic pulpitis. The aim of this study is to develop an experimental model of chronic pulpitis in an animal subject, specifically a rabbit of the Chinchilla breed, that reflects actual clinical conditions at various stages of development, the trajectory of infectious agent propagation, and the formation of inflammatory focus, thereby allowing for the study of this pathological process in dynamics. Research methods: descriptive, experimental, and pathohistologic. The proposed experimental model of chronic pulpitis using a biological object‒a rabbit of the Chinchilla breed, according to the stages of development, the path of spread of the infectious agent and the formation of inflammatory focus‒fully corresponds to the real clinical conditions of chronic pulpitis. Due to the sufficient size of the rabbit’s teeth, jaw bones, and circulating blood volume, it is optimal for the realization of material sampling when performing pathohistological and laboratory studies in dynamics, both during the development of the pathological process and during itstreatment. This makes it economically justified.
About the Authors
T. N. Terekhova
Belarusian State Medical University
Belarus
Belarus
Tamara N. Terekhova – D. Sc. (Med.), Professor
83, Dzerzhinski Ave., 220083, Minsk, Republic of Belarus
I. O. Pohodenko-Chudakova
Belarusian State Medical University
Belarus
Belarus
Irina O. Pohodenko-Chudakova – D. Sc. (Med.), Professor
83, Dzerzhinski Ave., 220083, Minsk, Republic of Belarus
T. A. Pyko
Belarusian State Medical University
Belarus
Belarus
Tatsiana A. Pyko – Assistant
83, Dzerzhinski Ave., 220083, Minsk, Republic of Belarus
Zh. A. Makarevich
Belarusian State Medical University
Belarus
Belarus
Zhanna A. Makarevich – veterinarian
83, Dzerzhinski Ave., 220083, Minsk, Republic of Belarus
K. S. Vorobʼyova
Belarusian State Medical University
Belarus
Belarus
Ksenija S. Vorobʼyova – Assistant
83, Dzerzhinski Ave., 220083, Minsk, Republic of Belarus
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Review
For citations:
Terekhova T.N., Pohodenko-Chudakova I.O., Pyko T.A., Makarevich Zh.A., Vorobʼyova K.S. A new experimental model of chronic pulpitis. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2025;22(3):239-245. (In Russ.) https://doi.org/10.29235/1814-6023-2025-22-3-239-245
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