Cannulated prolactin test in the diagnosis of the hyperprolactinemia syndrome
https://doi.org/10.29235/1814-6023-2024-21-1-79-88
Abstract
Hyperprolactinemia (HP) is a persistent pathological increase in a prolactin serum concentration amounting to more than 20 ng/ml in males and 25 ng/ml in females and leads to developing the pathological symptom complex of HP primarily from the reproductive system. To confirm the persistent etiology of HP and to eliminate physiological short-term hormone enhancement, a number of recommendations, including Russian and Belarusian, were proposed to make several prolactin measurements.
This study included 120 patients with HP (96 females, 78.0 %) and (27 males, 22.0 %) aged 18–50 years who sought medical help at the Health Institution “Minsk City Clinical Endocrinology Center” in the period from December 2022 to September 2023. After catheterizing the vein, a venous cannula was inserted and blood was taken immediately after cannulating (T0), and then in 60 minutes (T1) and 120 minutes (T2). The cannulated prolactin test results were considered positive – with HP remaining in all three samples (T0, T1, T2), questionable – if HP was kept at T0 and T1, and negative if HP was only at T0. When evaluating the cannulated test results, true HP is 36.7 %. Patients with a positive cannulated test had a higher prolactin at T0, which was 888.5 mME/L (U = 97.0; z = 7.92; p < 0.001). Patients with stress-induced HP (negative test) and patients with true HP (positive test) had no statistically significant differences in age and occurrence frequency of specific and non-specific complaints and symptoms for HP.
About the Authors
N. V. KarlovichBelarus
Natalia V. Karlovich ‒ D. Sc. (Med.), Professor
83, Dzerzhinski Ave., 220116, Minsk
O. N. Shishko
Belarus
Olga N. Shishko – Ph. D. (Med.), Deputy Chief for medical care
7, Kiselev Str., 220029, Minsk
M. A. Malyshko
Belarus
Maria A. Malyshko – endocrinologist
83, Shchedrin Str., 220051, Minsk
E. V. Yurenya
Belarus
Elena V. Yurenya – Chief Physician
7, Kiselev Str., 220029, Minsk
T. V. Mokhort
Belarus
Tatiana V. Mokhort – D. Sc. (Med.), Professor, Head of the Department
83, Dzerzhinski Ave., 220116, Minsk
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Review
For citations:
Karlovich N.V., Shishko O.N., Malyshko M.A., Yurenya E.V., Mokhort T.V. Cannulated prolactin test in the diagnosis of the hyperprolactinemia syndrome. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2024;21(1):79-88. https://doi.org/10.29235/1814-6023-2024-21-1-79-88
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