Effect of proline-containing oligopeptides on the behavior of outbred ICR mice in the Forced Swim Test
https://doi.org/10.29235/1814-6023-2023-20-3-256-264
Abstract
The effect of proline-containing oligopeptides N-Ac-DSer-Pro-DArg-Gly-NH2 (B-4), N-Ac-Trp-Pro-Arg-Gly-NH2 (B-5), N-Ac-Tyr-Pro-Arg-Gly-NH2 (B-7), and Pro-Gly on the behavior of male ICR mice in the Forced Swim Test was studied. N-Ac-DSer-Pro-DArg-Gly-NH2 (1.0 mcg/kg, i.n) increased the intensity of active swimming, most pronounced – during the last 2 minutes of testing (maximum fatigue period), i.e., it prevented the behavior of “despair”.
About the Authors
E. V. Kravchenko
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Elena V. Kravchenko ‒ Ph. D. (Biol.), Associate Professor, Leading Researcher, Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus.
5/2, Kuprevich Str., 220141, Minsk
L. M. Olgomets
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Lyubov M. Olgomets ‒ Senior Researcher, Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus.
5/2, Kuprevich Str., 220141, Minsk
O. N. Savanets
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Oksana N. Savanets ‒ Junior Researcher, Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus.
5/2, Kuprevich Str., 220141, Minsk
K. V. Borodina
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Kseniya V. Borodina ‒ Researcher, Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus.
5/2, Kuprevich Str., 220141, Minsk
E. S. Pustyulga
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Egor S. Pustyulga ‒ Researcher, Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus.
5/2, Kuprevich Str., 220141, Minsk
V. P. Golubovich
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Vladimir P. Golubovich ‒ Dr. Sc. (Biol.), Professor, Head of the Laboratory, Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus.
5/2, Kuprevich Str., 220141, Minsk
R. D. Zilberman
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Roman D. Zilberman ‒ Senior Researcher, Head of the Laboratory, Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus.
5/2, Kuprevich Str., 220141, Minsk
N. A. Bizunok
Belarusian State Medical University
Belarus
Belarus
Natalia A. Bizunok ‒ D. Sc. (Med.), Professor, Head of the Department, Belarusian State Medical University.
83, Dzerzhynski Ave., 220116, Minsk
B. V. Dubovik
Belarusian State Medical University
Belarus
Belarus
Boris V. Dubovik ‒ D. Sc. (Med.), Professor, Belarusian State Medical University.
83, Dzerzhynski Ave., 220116, Minsk
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Review
For citations:
Kravchenko E.V., Olgomets L.M., Savanets O.N., Borodina K.V., Pustyulga E.S., Golubovich V.P., Zilberman R.D., Bizunok N.A., Dubovik B.V. Effect of proline-containing oligopeptides on the behavior of outbred ICR mice in the Forced Swim Test. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2023;20(3):256-264. (In Russ.) https://doi.org/10.29235/1814-6023-2023-20-3-256-264
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