Preview

Proceedings of the National Academy of Sciences of Belarus, Medical series

Advanced search

Effect of proline-containing oligopeptides on the behavior of outbred ICR mice in the Forced Swim Test

https://doi.org/10.29235/1814-6023-2023-20-3-256-264

Abstract

The effect of proline-containing oligopeptides N-Ac-DSer-Pro-DArg-Gly-NH2 (B-4), N-Ac-Trp-Pro-Arg-Gly-NH2 (B-5), N-Ac-Tyr-Pro-Arg-Gly-NH2 (B-7), and Pro-Gly on the behavior of male ICR mice in the Forced Swim Test was studied. N-Ac-DSer-Pro-DArg-Gly-NH2 (1.0 mcg/kg, i.n) increased the intensity of active swimming, most pronounced – during the last 2 minutes of testing (maximum fatigue period), i.e., it prevented the behavior of “despair”.

For citations:


Kravchenko E.V., Olgomets L.M., Savanets O.N., Borodina K.V., Pustyulga E.S., Golubovich V.P., Zilberman R.D., Bizunok N.A., Dubovik B.V. Effect of proline-containing oligopeptides on the behavior of outbred ICR mice in the Forced Swim Test. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2023;20(3):256-264. (In Russ.) https://doi.org/10.29235/1814-6023-2023-20-3-256-264

Views: 300


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)