Profile of pro- and anti-inflammatory cytokines during injection of fatty acid amides with ethanolamine and glycine in modeling peripheral neuropathy
https://doi.org/10.29235/1814-6023-2023-20-3-183-190
Abstract
The effect of fatty acid amides during the blockade of membrane orphan GPR18, GPR55 and nuclear PPARα receptors on the level of pro- and anti-inflammatory cytokines in rats with experimental peripheral neuropathy was studied. It has been proven that the anti-inflammatory action of PEA and SEA in experimental animals with neuropathy is carried out through nuclear PPARα receptors. However, PGlyA has no anti-inflamatory effects in a rat model of peripheral neuropathy.
About the Authors
A. S. Doronkina
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Anastasya S. Doronkina – Postgraduate student, Junior Researcher, Institute of Physiology of the National Academy of Sciences of Belarus.
28, Akademicheskaya Str., 220072, Minsk
I. P. Zhavoronok
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Irina P. Zhavoronok – Ph. D. (Biol.), Head of the Laboratory, Institute of Physiology of the National Academy of Sciences of Belarus.
28, Akademicheskaya Str., 220072, Minsk
V. G. Bogdan
Department of Medical Sciences of the National Academy of Sciences of Belarus
Belarus
Belarus
Vasily G. Bogdan – D. Sc. (Med.), Professor, Academician-Secretary of the Department of Medical Sciences of the National Academy of Sciences of Belarus.
66, Nezavisimosti Ave., 220072, Minsk
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Review
For citations:
Doronkina A.S., Zhavoronok I.P., Bogdan V.G. Profile of pro- and anti-inflammatory cytokines during injection of fatty acid amides with ethanolamine and glycine in modeling peripheral neuropathy. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2023;20(3):183-190. (In Russ.) https://doi.org/10.29235/1814-6023-2023-20-3-183-190
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