ORGANELLOGENESIS FEATURES IN THE NEURONS OF THE CEREBRAL CORTEX OF RATS AFTER PRENATAL ALCOHOLIZATION
Abstract
The prenatal alcoholization has resulted in significant qualitative and quantitative disorders of organelles in the internal pyramidal neurons in the frontal cortex during postnatal ontogenesis, which corresponds to the structural and histochemical defects to be identified at the light-optical level. The revealed disorders of organellogenesis in the pyramidal neurons of the cerebral cortex may underlie the known irreversible neurological and behavioral disturbances in animals after prenatal alcoholization.
About the Authors
E. I. Bon
Grodno State Medical University
Russian Federation
Postgraduate student.
Russian Federation
Postgraduate student.
S. M. Zimatkin
Grodno State Medical University
Russian Federation
D. Sc. (Biol.), Professor, Head of the Department.
Russian Federation
D. Sc. (Biol.), Professor, Head of the Department.
References
1. Riley E. P., Infante M. A., Warren K. R. “Fetal alcohol spectrum disorders: an overview”, Neuropsychology Review, 2011, no. 21, pp. 73–78.
2. Zimatkin S. M., Bon E. I. Alkogol’nyi sindrom ploda [Alcohol syndrome of fetus], New knowledge, Moscow, RU, 2014.
3. Artyukhina N. I., Nozdracheva L. V. Narushenie strukturno-funktsional’noi organizatsii mitokhondrii kory golovnogo mozga belykh krys vsledstvii alkogolnoi intoksikatsii [Disorder of the structure-function organization of mitochondria of the white rat brain due to antenatal alcohol intoxication], Moscow, RU, 1988.
4. Popova E. N. Ultrastruktura mozga, alkogol’ i potomstvo [Brain ultrastructure, alcohol and posterity], Science World, Moscow, RU, 2010.
5. Bon’ E. I., Zimatkin S. M. “Dynamics of histological changes in the pariental cortex of rats subjected to alcohol”, Novosti mediko-biologicheskikh nauk [News of Biomedical Sciences], 2015, no. 2, pp. 146–151.
6. Bon’ E. I., Zimatkin S. M. “Involution of the cortex neurons of the rats taking alcohol during pregnancy”, Vestsі Natsyyanal’nai akademіі navuk Belarusі. Seryya medytsynskіkh navuk [Proceedings of the National Academy of Sciences of Belarus, Series of Medical Sciences], 2016, no. 1, pp. 59–64.
7. Karkishchenko N. N., Grachev S. V. Rukovodstvo po laboratornym zhivotnym i al’ternativnym modelyam v biomeditsinskikh issledovaniyakh [Manual on laboratory animals and alternative models in biomedical studies], Profile 2C, Moscow, RU, 2010.
8. Paxinos G., Watson C. The Rat Brain in stereotaxic coordinate, Academic Press, Australia, 1986.
Review
For citations:
Bon E.I., Zimatkin S.M. ORGANELLOGENESIS FEATURES IN THE NEURONS OF THE CEREBRAL CORTEX OF RATS AFTER PRENATAL ALCOHOLIZATION. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(1):123-128. (In Russ.)
Views:
454
Email this article 