IMPACT OF THE INTRANASAL APPLICATION OF GAMMA-AMINOBUTYRIC ACID ON THE MEMORY PROCESSES OF RATS UNDER HYPOXIA CONDITIONS
Abstract
In the experiments on 22 adult male rats with a conditioned reflex of avoidance prepared in the shuttle chamber, it was found that a single application of gamma-amino butyric acid (3 mg/ml in a volume of 20 μl) at the nasal mucosa of rats was accompanied by deceleration of the extinction process of the conditioned reflex to 2–3 weeks compared with controls. The intranasal application of gamma-amino butyric acid before hypobaric hypoxia (5 min) contributed to the restoration of the natural pattern of extinction of the conditioned reflex, which was typical for the control animals.
Thus, the impact of classical inhibitory neurotransmitter on the vomeronasal organ in rats was characterized by the restructuring of the integrative activity of the brain and the improvement of learning and memory mechanisms that were vulnerable to reduced oxygen tension in the brain tissues.
Thus, the impact of classical inhibitory neurotransmitter on the vomeronasal organ in rats was characterized by the restructuring of the integrative activity of the brain and the improvement of learning and memory mechanisms that were vulnerable to reduced oxygen tension in the brain tissues.
About the Authors
G. P. Mironova
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Ph. D. (Biol.), Senior researcher.
Belarus
Ph. D. (Biol.), Senior researcher.
S. G. Pashkevich
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Ph. D. (Biol.), Head of the Laboratory.
Belarus
Ph. D. (Biol.), Head of the Laboratory.
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Review
For citations:
Mironova G.P., Pashkevich S.G. IMPACT OF THE INTRANASAL APPLICATION OF GAMMA-AMINOBUTYRIC ACID ON THE MEMORY PROCESSES OF RATS UNDER HYPOXIA CONDITIONS. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(1):103-110. (In Russ.)
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