CELL MECHANISMS OF ANTRACYCLINE CARDIOMYOPATHY UNDER ANTIBIOTIC DOXORUBICIN TREATMENT

L. I. Archakova; S. A. Novakovskaya

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CELL MECHANISMS OF ANTRACYCLINE CARDIOMYOPATHY UNDER ANTIBIOTIC DOXORUBICIN TREATMENT

L. I. Archakova, S. A. Novakovskaya

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Abstract

In this article we presented the results of electron microscopy of the laboratory rat myocardium after doxorubicin treatment. The heart damage and the development of cardiomyopathy under antracycline antibiotic doxorubicin were established. Pathogenesis and morphology of heart complications caused by this cytostatic were studied. It was established that doxorubicin induces dystrophy, necrosis, apoptosis, and autophagy in some cardiomyocytes of damage heart. Fibrosis of the connective tissue in myocardium is a cause of tissue ischemia and the development of chronic heart failure.

Keywords

doxorubicin treatment, cardiomyopathy, electron microscopy, necrosis, apoptosis

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For citations:

Archakova L.I., Novakovskaya S.A. CELL MECHANISMS OF ANTRACYCLINE CARDIOMYOPATHY UNDER ANTIBIOTIC DOXORUBICIN TREATMENT. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(1):83-89. (In Russ.)

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)

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Proceedings of the National Academy of Sciences of Belarus, Medical series

CELL MECHANISMS OF ANTRACYCLINE CARDIOMYOPATHY UNDER ANTIBIOTIC DOXORUBICIN TREATMENT

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