IMPACT OF MICROBIOLOGICAL PREPARATIONS EM-1 AND EMX-GOLD ON BIOKINETICS OF 137CS IN THE LABORATORY ANIMALS
Abstract
The effect of microbiological preparations EM-1 and EMX-Gold on the accumulation and excretion of 137Cs in white laboratory male rats after oral administration of radionuclide is investigated. EM-1 is a complex of symbiotic cultured microorganisms: lactic acid bacteria, yeasts, purple photosynthetic bacteria. EMX-Gold is a dietary supplement based on extracts from EM-1. It consists of a set of secondary metabolites isolated from the culture of the symbiotic microorganisms. The activity of 137Cs in the daily diet was 34.95 ± 5.62 Bq/day. After two months of keeping animals on feed contaminated with 137Cs, the equilibrium activity of radioisotope in the body of animals was reached. It is equal to 210–230 Bq/kg. Eight days after changing the diet free of the radioisotope feed, decreasing the 137Cs activity concentration in the bodies of rats by 36–39 % is established. The effective half-life of 137Cs in the bodies of 8-month-old rats under chronic 2-month ingestion of radioisotope was 352 ± 69 hours, for 10-month-old animals this index is equal to 394 ± 148 hours. Introduction of EM-1 or EMX-Gold into the diet over a period of 2 months reduces the effective half-life of 137Cs by 16–19 % (p < 0.15). A permanent addition of the microbial preparation EM-1 or EMX-Gold to drinking water does not alter the rate of excretion of radionuclide from the body after the 4-month maintenance of male rats on a diet contaminated with radioactive cesium.
About the Authors
I. A. Cheshyk
Institute of Radiobiology of the National Academy of Sciences of Belarus
Belarus
Ph. D. (Med.), Associate Professor, Director
Belarus
Ph. D. (Med.), Associate Professor, Director
A. N. Nikitin
Institute of Radiobiology of the National Academy of Sciences of Belarus
Belarus
Ph. D. (Agricult.), Head of the Laboratory.
Belarus
Ph. D. (Agricult.), Head of the Laboratory.
D. V. Sukhareva
Institute of Radiobiology of the National Academy of Sciences of Belarus
Belarus
Researcher
Belarus
Researcher
E. A. Medvedeva
Institute of Radiobiology of the National Academy of Sciences of Belarus
Belarus
Junior researcher.
Belarus
Junior researcher.
S. O. Gaponenka
Institute of Radiobiology of the National Academy of Sciences of Belarus
Belarus
Junior researcher.
Belarus
Junior researcher.
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Review
For citations:
Cheshyk I.A., Nikitin A.N., Sukhareva D.V., Medvedeva E.A., Gaponenka S.O. IMPACT OF MICROBIOLOGICAL PREPARATIONS EM-1 AND EMX-GOLD ON BIOKINETICS OF 137CS IN THE LABORATORY ANIMALS. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(1):46-53. (In Russ.)
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