ROLE OF THE KUPFFER CELLS AND THE L-ARGININE-NO SYSTEM IN DETOXICATION PROCESSES AND OXIDATIVE STRESS IN THE RAT’S LIVER WITHIN CHRONIC ALCOHOLIZATION
Abstract
In experiments on rats it was shown that chronic ethanol intoxication causes Kupffer cells activation, depression of detoxication processes, increase in the content of lipid peroxidation products in blood and liver, the level of NO3–/NO2– and the activity of alanine aminotransferase and aspartate aminotransferase in plasma. Inhibition of the activity of Kupffer cells by gadolinium chloride, as NO-syntase activity by L-NAME, reduces the toxic effect of ethanol on the liver, as well as the development of typical changes in the processes of lipid peroxidation, detoxication, the levels of NO3–/NO2– in blood plasma in rats with chronic alcoholization. The functional state of Kupffer cells and the L-arginine-NO system activity, the nitric oxide production is the important factors of realizing the ethanol influence on detoxication and peroxidation processes in the liver.
About the Authors
F. I. Vismont
Belarusian State Medical University
Russian Federation
Corresponding Member, D. Sc. (Med.), Professor, Head of the Depart-
ment.
Russian Federation
Corresponding Member, D. Sc. (Med.), Professor, Head of the Depart-
ment.
V. V. Lobanova
Belarusian State Medical University
Russian Federation
Applicant of the Department.
Russian Federation
Applicant of the Department.
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Review
For citations:
Vismont F.I., Lobanova V.V. ROLE OF THE KUPFFER CELLS AND THE L-ARGININE-NO SYSTEM IN DETOXICATION PROCESSES AND OXIDATIVE STRESS IN THE RAT’S LIVER WITHIN CHRONIC ALCOHOLIZATION. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2017;(1):15-20. (In Russ.)
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