Developmental disorders of neurons in the frontal cortex of antenatal rats after exposure to alcohol

Abstract

Prenatal alcoholisation leads to the development of a number of specific disorders of the fetus, united in the concept of the fetal alcohol syndrome (FAS), included in the "fetal alcohol spectrum disorders" FASD. Antenatal alcoholisation slows down the maturation of neurons in the frontal cortex of the offspring of rats that consumed alcohol during pregnancy, resulting in the inhibition of maturation in their perikaryon of the expression of doublecortin (DCX) and the rise of NeuN protein expression.