Nephroprotective action of the combination of taurine with zinc diaspartate in rats with sublimate nephropathy
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Abstract
In experiment on 32 outbred male rats, by the histochemical and biochemical methods it is established that the combination of taurine (20 g/mole - 2.50 g) with zinc diaspartate (1 g/mole - 0.35 g), which is entered into the stomach at a dose of 250 and 500 mg/kg/day everyday, has a nephroprotective dose-dependent action in rats with sublimate nephropathy (intraperitoneally; 0.1 mg/100 g/day, everyday - 14 dose). As evidenced by the activation of key inhibited SDG and AP in kidneys and the improvement of biochemical markers of nephrotoxicity in plasma (decrease in the content of creatinine, increase in its clearance) and urine (increase in the exretion of urea, creatinine, uric acid, polyuria reduction).
About the Authors
O. N. Basalai
Grodno State Medical University
Belarus
Belarus
E. Ch. Mikhalchuk
Grodno State Medical University
Belarus
Belarus
M. I. Bushma
Grodno State Medical University
Belarus
Belarus
S. M. Zimatkin
Grodno State Medical University
Belarus
Belarus
V. M. Sheybak
Grodno State Medical University
Belarus
Belarus
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Review
For citations:
Basalai O.N., Mikhalchuk E.Ch., Bushma M.I., Zimatkin S.M., Sheybak V.M. Nephroprotective action of the combination of taurine with zinc diaspartate in rats with sublimate nephropathy. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2015;(3):53-56. (In Russ.)
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ISSN 1814-6023 (Print)
ISSN 2524-2350 (Online)
ISSN 2524-2350 (Online)
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