vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2024-21-3-231-240vestim-985Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEЭкспериментальное моделирование стриктуры холедохоеюноанастомозаExperimental modeling of the choledochojunoanastomosis stricturehttps://orcid.org/0000-0002-9923-9008ОрловскийЮ. Н.ArlouskiYu. N.

Орловский Юрий Николаевич – канд. мед. наук, доцент

п. Лесной, 31, 220030, Минский р-н

Yury N. Arlouski ‒ Ph. D. (Med.), Associate Professor

31, Lesnoy, 220030, Minsk district

arlouski1392@yandex.ruhttps://orcid.org/0000-0001-7622-5642ГаинЮ. М.GainYu. M.

Гаин Юрий Михайлович – д-р мед. наук, профессор

п. Лесной, 31, 220030, Минский р-н

Yury M. Gain – D. Sc. (Med.), Professor

31, Lesnoy, 220030, Minsk district

gain@tut.byВладимирскаяТ. Э.VladimirskayaT. E.

Владимирская Татьяна Эрнстовна – канд. биол. наук, доцент, руководитель отдела

п. Лесной, 31, 220030, Минский р-н

Tatuana E. Vladimirskaya – Ph. D. (Biol.), Associate Professor, Head of the Department

31, Lesnoy, 220030, Minsk district

tan_2304@inbox.ruhttps://orcid.org/0009-0002-0904-5734ЮрагаТ. М.YuragaT. M.

Юрага Тамара Михайловна – ст. науч. сотрудник

п. Лесной, 31, 220030, Минский р-н

Tamara M. Yuraga – Senior Researcher

31, Lesnoy, 220030, Minsk district

6914593@mail.ruЧерновО. Н.ChernovO. N.

Чернов Олег Николаевич – врач-хирург

ул. Кижеватова, 58, 220024, г. Минск

Oleg N. Chernov – Surgeon

58, Kizhevatov Str., 220024, Minsk

olegchernovby@gmail.comБелорусский государственный медицинский университетBelarusian State Medical UniversityГородская клиническая больница скорой медицинской помощи г. МинскаCity Clinical Hospital of Emergency Medical Care of Minsk202403092024213231240Copyright © Орловский Ю.Н., Гаин Ю.М., Владимирская Т.Э., Юрага Т.М., Чернов О.Н., 20242024Орловский Ю.Н., Гаин Ю.М., Владимирская Т.Э., Юрага Т.М., Чернов О.Н.Arlouski Y.N., Gain Y.M., Vladimirskaya T.E., Yuraga T.M., Chernov O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/985

В результате экспериментального моделирования стриктуры холедохоеюноанастомоза на лабораторных животных выявлена роль специфических биомаркеров в установлении причин избыточного рубцевания билиодигестивных соустий. Предлагаемая модель позволяет изучить фазность течения патологического процесса и патогенеза развития стриктуры холедохоеюноанастомоза и наметить пути профилактики ее формирования в клинических условиях.

As a result of experimental modeling of the choledochojejunostomy stricture n laboratory animals, the role of specific biomarkers in establishing the causes of excessive scarring of biliodigestive anastomoses was revealed. The proposed model is suitable for studying the phase nature of the pathological process and the pathogenesis of development of the choledochojejunostomy stricture, allowing one to outline ways how to prevent its formation in a clinical setting.

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The authors declare that there are no conflicts of interest present.