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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vestim</journal-id><journal-title-group><journal-title xml:lang="ru">Известия Национальной  академии наук Беларуси. Серия медицинских наук</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of the National Academy of Sciences of Belarus, Medical series</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-6023</issn><issn pub-type="epub">2524-2350</issn><publisher><publisher-name>The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29235/1814-6023-2023-20-3-236-242</article-id><article-id custom-type="elpub" pub-id-type="custom">vestim-929</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL AND EXPERIMENTAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Генеалогическая диагностика новообразований на основе систем искусственного интеллекта</article-title><trans-title-group xml:lang="en"><trans-title>Genealogical diagnostics of neoplasms based on artificial intelligence systems</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1348-8688</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецов</surname><given-names>О. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzniatsou</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузнецов Олег Евгеньевич –   кандидат биологических наук, доцент, директор.</p><p>пл. Антония Тызенгауза, 7, 230012, Гродно</p></bio><bio xml:lang="en"><p>Aleh E. Kuzniatsou – Ph. D. (Biol.), Associate Professor, Director, Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus.</p><p>7, Antonii Tyzengauz Sq., 230012, Grodno</p></bio><email xlink:type="simple">olegkuznetsov@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт биохимии биологически активных соединений НАН Беларуси</institution></aff><aff xml:lang="en"><institution>Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>02</day><month>09</month><year>2023</year></pub-date><volume>20</volume><issue>3</issue><fpage>236</fpage><lpage>242</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кузнецов О.Е., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Кузнецов О.Е.</copyright-holder><copyright-holder xml:lang="en">Kuzniatsou A.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestimed.belnauka.by/jour/article/view/929">https://vestimed.belnauka.by/jour/article/view/929</self-uri><abstract><p>Составление и анализ родословных – один из методов популяционной генетики, позволяющий выявить предрасположенность к той или иной онкологической патологии. В настоящее время актуальным является доказательство целесообразности разработки и внедрения в клиническую практику комплексного метода диагностики и профилактики опухолей на основе данных генетического консультирования, молекулярно-биологических исследований и современных технологий искусственного интеллекта. Предложена информационно-аналитическая система, позволяющая анализировать данные пациента, полученные в ходе консультирования, с возможностью дополнения их информацией из медицинской истории и результатами исследования. Предлагаемая информационная система способна анализировать родословную и давать предварительное заключение о наличии риска возникновения опухолевого процесса у членов семьи пациента по алгоритмам накопленной в регионе заболеваемости.</p></abstract><trans-abstract xml:lang="en"><p>The compilation and analysis of the patient’s genealogies is one of the methods of population genetics, which makes it possible to identify a predisposition to a particular oncological pathology. At present, it is relevant to prove the feasibility of developing and introducing into clinical practice a comprehensive method for diagnosing and preventing tumors based on data from genetic counseling, molecular biological research and modern artificial intelligence technologies. An information-analytical system is proposed that allows analyzing the patient’s data obtained during the consultation, with the possibility of supplementing them with information from the medical history and the results of the study. The proposed information system is able to analyze of the genealogy and give a preliminary conclusion about the risk of a tumor process in the patient’s family members, according to the algorithms of the morbidity accumulated in the region.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>онкология</kwd><kwd>генетическое консультирование</kwd><kwd>искусственный интеллект</kwd><kwd>диагностическая система</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oncology</kwd><kwd>genetic counseling</kwd><kwd>artificial intelligence</kwd><kwd>diagnostic system</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Order of the Ministry of Health of the Republic of Belarus “On Approval of the Concept for the Development of Electronic Health in the Republic of Belarus”. March 20, 2018, no. 244 (in Russian).</mixed-citation><mixed-citation xml:lang="en">Order of the Ministry of Health of the Republic of Belarus “On Approval of the Concept for the Development of Electronic Health in the Republic of Belarus”. March 20, 2018, no. 244 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cherstvoi E. D., Kravtsova G. I., Furmanchuk A. V., Gerasimovich A. I., Grigor’ev D. G., Demidchik Yu. E., Dubrovskii A. Ch., Kletskii S. K., Letkovskaya T. A., Nerovnya A. M., Sachivko N. V. Tumors and tumor-like processes in children. Minsk, Asar Publ., 2002. 399 p. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Cherstvoi E. D., Kravtsova G. I., Furmanchuk A. V., Gerasimovich A. I., Grigor’ev D. G., Demidchik Yu. E., Dubrovskii A. Ch., Kletskii S. K., Letkovskaya T. A., Nerovnya A. M., Sachivko N. V. Tumors and tumor-like processes in children. Minsk, Asar Publ., 2002. 399 p. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Siegel R. L., Miller K. D., Jemal A. Cancer statistics, 2020. CA: a Cancer Journal for Clinicians, 2020, vol. 70, no. 1, рр. 7–30. https://doi.org/10.3322/caac.21590</mixed-citation><mixed-citation xml:lang="en">Siegel R. L., Miller K. D., Jemal A. Cancer statistics, 2020. CA: a Cancer Journal for Clinicians, 2020, vol. 70, no. 1, рр. 7–30. https://doi.org/10.3322/caac.21590</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization (WHO). Global Health Estimates 2020: Deaths by Cause, Age, Sex, by Country and by Region, 2000–2019. WHO; 2020. Available at: who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-leading-causes-of-death (accessed 11.04.2022).</mixed-citation><mixed-citation xml:lang="en">World Health Organization (WHO). Global Health Estimates 2020: Deaths by Cause, Age, Sex, by Country and by Region, 2000–2019. WHO; 2020. Available at: who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-leading-causes-of-death (accessed 11.04.2022).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sung H., Ferlay J., Siegel R. L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. American Cancer Society. CA: a Cancer Journal for Clinicians, 2021, vol. 71, no. 3, рр. 209–249. https://doi.org/10.3322/caac.21660</mixed-citation><mixed-citation xml:lang="en">Sung H., Ferlay J., Siegel R. L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. American Cancer Society. CA: a Cancer Journal for Clinicians, 2021, vol. 71, no. 3, рр. 209–249. https://doi.org/10.3322/caac.21660</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">The Global Cancer Observatory (GLOBOCAN) – International Agency for Research of Cancer, IARC. Available at: https://gco.iarc.fr/today/online-analysis-map?v=2020 (accessed 14.04.2022).</mixed-citation><mixed-citation xml:lang="en">The Global Cancer Observatory (GLOBOCAN) – International Agency for Research of Cancer, IARC. Available at: https://gco.iarc.fr/today/online-analysis-map?v=2020 (accessed 14.04.2022).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Plummer M., de Martel C., Vignat J., Ferlay J., Bray F., Franceschi S. Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Global Health, 2016, vol. 4, no. 9, рр. e609–e616. https://doi.org/10.1016/S2214-109X(16)30143-7</mixed-citation><mixed-citation xml:lang="en">Plummer M., de Martel C., Vignat J., Ferlay J., Bray F., Franceschi S. Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Global Health, 2016, vol. 4, no. 9, рр. e609–e616. https://doi.org/10.1016/S2214-109X(16)30143-7</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kuznetsov O. E., Tsyrkunov V. M. Virus-associated hepatocellular liver cancer. Gepatologiya i gastroenterologiya [Hepatology and gastroenterology], 2021, vol. 5, no. 1, pp. 17–24 (in Russian).</mixed-citation><mixed-citation xml:lang="en">Kuznetsov O. E., Tsyrkunov V. M. Virus-associated hepatocellular liver cancer. Gepatologiya i gastroenterologiya [Hepatology and gastroenterology], 2021, vol. 5, no. 1, pp. 17–24 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Crawford K. Atlas of AI: Power, Politics, and the Planetary Costs of Artificial Intelligence. New Haven, Yale University Press, 2021. 336 p.</mixed-citation><mixed-citation xml:lang="en">Crawford K. Atlas of AI: Power, Politics, and the Planetary Costs of Artificial Intelligence. New Haven, Yale University Press, 2021. 336 p.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kuznetsov O. E., Shpakov A. I. Diagnostics and prevention of oncological diseases based on genetic counseling and modern information technologies. Voprosy organizatsii i informatizatsii zdravookhraneniya [Issues of organization and informatization of healthcare], 2019, no. 4, pp. 60–65 (in Russian).</mixed-citation><mixed-citation xml:lang="en">Kuznetsov O. E., Shpakov A. I. Diagnostics and prevention of oncological diseases based on genetic counseling and modern information technologies. Voprosy organizatsii i informatizatsii zdravookhraneniya [Issues of organization and informatization of healthcare], 2019, no. 4, pp. 60–65 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Muller V. C., Bostrom N. Future Progress in Artificial Intelligence: A Survey of Expert Opinion. Fundamental Issues of Artificial Intelligence. Cham, 2016, pp. 555–572.</mixed-citation><mixed-citation xml:lang="en">Muller V. C., Bostrom N. Future Progress in Artificial Intelligence: A Survey of Expert Opinion. Fundamental Issues of Artificial Intelligence. Cham, 2016, pp. 555–572.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Weinberger M. How Microsoft’s top scientists have built a big business in hacking healthcare – and helped a lot of people along the way. Business Insider. 2018. Available at: http://www.businessinsider.com/peter-lee-microsoft-research-healthcare-next-interview-2018-2 (accessed 22.03.2022).</mixed-citation><mixed-citation xml:lang="en">Weinberger M. How Microsoft’s top scientists have built a big business in hacking healthcare – and helped a lot of people along the way. Business Insider. 2018. Available at: http://www.businessinsider.com/peter-lee-microsoft-research-healthcare-next-interview-2018-2 (accessed 22.03.2022).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kahneman D., Slovic P., Tversky A. (eds.). Judgment under Uncertainty: Heuristics and Biases. Cambridge, Cambridge University Press (21st.), 2005. 555 p.</mixed-citation><mixed-citation xml:lang="en">Kahneman D., Slovic P., Tversky A. (eds.). Judgment under Uncertainty: Heuristics and Biases. Cambridge, Cambridge University Press (21st.), 2005. 555 p.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kuznetsov O. E. Information system for accounting and monitoring of oncological diseases: pt. 675. Belarus. S20140041. 20.06.2014. Official Bulletin. Center for Intellectual Property (in Russian).</mixed-citation><mixed-citation xml:lang="en">Kuznetsov O. E. Information system for accounting and monitoring of oncological diseases: pt. 675. Belarus. S20140041. 20.06.2014. Official Bulletin. Center for Intellectual Property (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lynch H. T., Smyrk T., Lynch J. F. Molecular genetics and clinical-pathological features of hereditary nonpolyposis colorectal carcinoma (Lynch syndrome): historical journey from pedigree anecdote to molecular genetic confurmation. Oncology, 1998, no. 55, no. 2, pp. 103–108. https://doi.org/10.1159/000011843</mixed-citation><mixed-citation xml:lang="en">Lynch H. T., Smyrk T., Lynch J. F. Molecular genetics and clinical-pathological features of hereditary nonpolyposis colorectal carcinoma (Lynch syndrome): historical journey from pedigree anecdote to molecular genetic confurmation. Oncology, 1998, no. 55, no. 2, pp. 103–108. https://doi.org/10.1159/000011843</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
