vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2022-19-4-424-432vestim-881Research ArticleОБЗОРЫREVIEWSОбеспеченность населения витамином D в период пандемии COVID-19: опыт России и БеларусиVitamin D status during the COVID-19 pandemic: the experience of Russia and Belarushttps://orcid.org/0000-0002-1547-0123КароноваТ. Л.KaronovaT. L.

Каронова Татьяна Леонидовна – доктор медицинских наук, доцент.

пр. Пархоменко, 15, 194021, Санкт-Петербург

Tatiana L. Karonova – D. Sc. (Med.), Associate Professor, Almazov National Medical Research Centre.

15, Parkhomenko Ave., 194021, St. Petersburg

karonova@mail.ruhttps://orcid.org/0000-0003-4281-0880РуденкоЕ. В.RudencoE. V.

Руденко Елена Викторовна – кандидат медицинских наук, доцент.

ул. П. Бровки, 3/3, 220013, Минск

Elena V. Rudenco – Ph. D. (Med.), Associate Professor, Belarusian Medical Academy of Postgraduate Education.

3/3, P. Brovka Str., 220013, Minsk

alenka.v.ru@gmail.comhttps://orcid.org/0000-0003-1383-2474РадаеваО. А.RadaevaO. A.

Радаева Ольга Александровна – кандидат медицинских наук, доцент.

ул. Большевистская, 68, 430005, Саранск

Olga A. Radaeva – Ph. D. (Med.), Associate Professor, Ogarev Mordovia State University.

68, Bol’shevistskaya Str., 430005, Saransk

vtlbwbyf_79@mail.ruhttps://orcid.org/0000-0002-4878-6909ЧерниковаА. Т.ChernikovaA. T.

Черникова Алена Тимуровна – младший научный сотрудник.

пр. Пархоменко, 15, 194021, Санкт-Петербург

Alena T. Chernikova – Junior Researcher, Almazov National Medical Research Centre.

15, Parkhomenko Ave., 194021, St. Petersburg

arabicaa@gmail.comhttps://orcid.org/0000-0002-0651-7110ГоловатюкК. А.GolovatyukK. A.

Головатюк Ксения Андреевна – младший научный сотрудник.

пр. Пархоменко, 15, 194021, Санкт-Петербург

Ksenia A. Golovatyuk – Junior Researcher, Almazov National Medical Research Centre.

15, Parkhomenko Ave., 194021, St. Petersburg

ksgolovatiuk@gmail.comhttps://orcid.org/0000-0003-2929-0980ШляхтоЕ. В.ShlyakhtoE. V.

Шляхто Евгений Владимирович – академик, доктор медицинских наук.

ул. Аккуратова, 2, 197341, Санкт-Петербург

Evgeny V. Shlyakhto – Academician, D. Sc. (Med.), Almazov National Medical Research Centre.

2, Akkuratov Str., 197341, St. Petersburg

shlyakhto_ev@almazovcentre.ruНациональный медицинский исследовательский центр им. В.А. АлмазоваAlmazov National Medical Research CentreБелорусская медицинская академия последипломного образованияBelarusian Medical Academy of Postgraduate EducationМордовский государственный университет им. Н.П. ОгареваOgarev Mordovia State University202229112022194424432Copyright © Каронова Т.Л., Руденко Е.В., Радаева О.А., Черникова А.Т., Головатюк К.А., Шляхто Е.В., 20222022Каронова Т.Л., Руденко Е.В., Радаева О.А., Черникова А.Т., Головатюк К.А., Шляхто Е.В.Karonova T.L., Rudenco E.V., Radaeva O.A., Chernikova A.T., Golovatyuk K.A., Shlyakhto E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/881

В период пандемии COVID-19 сохраняется высокая распространенность дефицита и недостаточности витамина D. Так, исследования, выполненные в Российской Федерации и Республике Беларусь в течение последних 3 лет, показали преобладание дефицита и недостаточности витамина D в популяции независимо от пола обследованных лиц, географического положения региона и сезона года.

Учитывая известные иммуномодулирующие свойства 25(ОН)D в сыворотке крови, целью настоящего обзора было обсуждение накопленных в мире, а также в России и Беларуси данных о возможном вкладе дефицита витамина D      в инфицированность, течение и прогноз новой коронавирусной инфекции, а также об эффективности терапии колекальциферолом в профилактике и лечении заболевания. Большинство исследований указывают на наличие отрицательной связи между концентрацией 25(OH)D в сыворотке крови и тяжестью COVID-19 и/или смертностью. Ранее было показано, что уровень 25(ОН)D менее 11,4 нг/мл ассоциирован с увеличением риска летальности от коронавирусной инфекции. В то же время данные об использовании терапии колекальциферолом с целью профилактики и лечения COVID-19 противоречивы. Проведенные в России и Республике Беларусь интервенционные исследования малочисленны, однако их результаты указывают на возможную пользу терапии колекальциферолом, что позволяет рассматривать ее в качестве дополнения к основным методам лечения COVID-19.

During the COVID-19 pandemic, a high prevalence of vitamin D deficiency and insufficiency remains. Thus, the studies carried out on the territory of the Russian Federation (RF) and the Republic of Belarus over the last 3 years have shown the prevalence of vitamin D deficiency and insufficiency in the population, regardless of the gender of examined persons, the geographic location and the season of the year. Taking into account the known immunomodulatory functions of serum 25(OH)D, the aim of this review was to assess the data that were accumulated in the world, Russia and Belarus and were concerned with a possible contribution of vitamin D deficiency to COVID-19 infection, course and prognosis, as well as with the role of cholecalciferol therapy in prevention and treatment of the disease. Most of the studies demonstrate a negative association between the serum 25(OH)D level and COVID-19 severity and/or mortality. Previously, it has been shown that the serum 25(OH)D level less than 11.4 ng/ml is associated with an increased risk of COVID-19 mortality. At the same time, the results of the studies using cholecalciferol therapy for COVID-19 prevention and treatment are conflicting. Intervention  studies in the Russian Federation and the Republic of Belarus are scanty; however, the available data indicate a possible  benefit of therapy, which allows it to be considered as an addition to the main methods of treating COVID-19.

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The authors declare that there are no conflicts of interest present.