vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2022-19-4-413-423vestim-880Research ArticleОБЗОРЫREVIEWSПеченочно-интестинальная ось: физиология сквозь призму микробиомаGut-liver axis: physeology through the prism of the microbiomeСалимовУ. Р.SalimovU. R.

Салимов Умид Равшанович – кандидат медицинских наук, докторант.

ул. Семашко, 8, 220045, Минск

Umid R. Salimov – Ph. D. (Med.), Doctoral student, Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology.

8, Semashko Str., 220045, Minsk

ussalimov@gmail.comСтомаИ. О.StomaI. O.

Стома Игорь Олегович – доктор медицинских наук, профессор, ректор.

ул. Ланге, 5, 246000, Гомель

Igor O. Stoma – D. Sc. (Med.), Professor, Rector, Gomel State Medical University.

5, Lange Str., 246000, Gomel

igor.stoma@gmail.comКовалевА. А.KovalevA. A.

Ковалев Алексей Алексеевич – старший преподаватель.

ул. Ланге, 5, 246000, Гомель

Aliaksei A. Kovalev ‒ senior lecturer, Gomel State Medical University.

5, Lange  Str.,  246000,  Gomel

kovalev.data.analysis.gsmu@yandex.byЩербаА. Е.ScherbaA. E.

Щерба Алексей Евгеньевич – доктор медицинских наук, заместитель директора.

ул. Семашко, 8, 220045, Минск

Aliaksei E. Shcherba – D. Sc. (Med.), Deputy Director, Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology.

8, Semashko Str., 220045, Minsk

aleina@tut.byШтуричИ. П.ShturichI. P.

Штурич Иван Павлович ‒ кандидат медицинских наук, доцент, заведующий отделением.

ул. Семашко, 8, 220045, Минск

Ivan P. Shturich ‒ Ph. D. (Med.), Associate Professor, Head of the Department, Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology.

8, Semashko Str., 220045, Minsk

rcotrb@gmail.comРуммоО. О.RummoO. O.

Руммо Олег Олегович ‒ академик, доктор медицинских наук, профессор, директор.

ул. Семашко, 8, 220045, Минск

Oleg O. Rummo ‒ Academician, D. Sc. (Med.), Professor, Director, Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology.

8, Semashko Str., 220045, Minsk

olegrumm@tut.byМинский научно-практический центр хирургии, трансплантрологии и гематологииMinsk Scientific Practical Center of Surgery, Transplantology and HematologyГомельский государственный медицинский университетGomel State Medical University202229112022194413423Copyright © Салимов У.Р., Стома И.О., Ковалев А.А., Щерба А.Е., Штурич И.П., Руммо О.О., 20222022Салимов У.Р., Стома И.О., Ковалев А.А., Щерба А.Е., Штурич И.П., Руммо О.О.Salimov U.R., Stoma I.O., Kovalev A.A., Scherba A.E., Shturich I.P., Rummo O.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/880

В данной работе представлено краткое историческое описание эволюции взглядов на развитие концепции функционирования печеночно-интестинальной оси и ее физиологии. Описаны и обсуждены основные принципы физиологического функционирования нового, «виртуального», органа человека и их роль в патогенезе заболеваний печени, в том числе после перенесенной трансплантации печени.

Приведены полученные нами данные о секвенировании нового поколения, дающие представление о микробиомной палитре пациентов, страдающих хроническими диффузными заболеваниями печени различной этиологии. Cобственное исследование было представлено на основании изучения данных 12 обследованных в пред- и посттрансплантационном периоде пациентов, страдающих хроническими диффузными поражениями печени. Полученные результаты свидетельствуют о важном значении микробиома кишечника в естественном процессе реконвалесценции после перенесенной трансплантации печени.

This paper presents a brief historical description of the evolution of views on the development of the concept of the gut liver axis functioning and its physiological aspects. The “new virtual human organ” physiological fundamentals and their role in the pathogenesis of chronic liver diseases, including late post-transplant period, are described and discussed.

Based on own experience, results of a new generation sequencing describing the characteristics of the microbiome palette in patients suffering from chronic liver diseases of various etiologies are presented. Personal study was based on 12 patients suffering chronic liver disease, who were examined before and after liver transplantation. The obtained results indicate the importance of the intestinal microbiome in the natural process of recovery after liver transplantation.

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The authors declare that there are no conflicts of interest present.