vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2022-19-3-278-289vestim-862Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEКомплекснае макраскапічнае, гісталагічнае і электронна-мікраскапічнае даследаванне загойвання паўнаслойнай скурнай раны ў лабараторных пацукоўComplex macroscopic, histological, and electron microscopic examination of the healing of a full-thickness skin wound in laboratory ratsАстроўскіА. А.AstrowskiA. A.

Астроўскі Аляксандр Аляксандравіч – д-р мед. навук, прафесар, вядуч. навук. супрацоўнік.

БЛК, 50, 230030, Гродна

Aliaksandr A. Astrowski – D. Sc. (Med.), Professor, Leading Researcher.

50, BLK, 230030, Grodno

astrowski@gmail.comБакуновічА. А.BakunovichA. А.

Бакуновіч Аляксей Аляксеевіч – мал. навук. супрацоўнік.

БЛК, 50, 230030, Гродна

Aliaksei A. Bakunovich – Junior Researcher.

50, BLK, 230030, Grodno

baptist.alexei@mail.ruАстроўскаяА. Б.AstrowskajaA. B.

Астроўская Аксана Барысаўна – канд. біял. навук, дацэнт, ст. навук. супрацоўнік.

Вул. Горкага, 80, 230009, Гродна

Aksana B. Astrowskaja – Ph. D. (Biol.), Associate Professor, Senior Researcher.

80, Gorky Str., 230009, Grodno

astrowskaja@gmail.comІнстытут біяхіміі біялагічна актыўных злучэнняў, НАН БеларусіInstitute of Biochemistry of Biologically Active Compounds, National Academy of Sciences of BelarusГродзенскі дзяржаўны медыцынскі ўніверсітэтGrodno State Medical University202208092022193278289Copyright © Астроўскі А.А., Бакуновіч А.А., Астроўская А.Б., 20222022Астроўскі А.А., Бакуновіч А.А., Астроўская А.Б.Astrowski A.A., Bakunovich A.А., Astrowskaja A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/862

З дапамогай макра-, мікра- і ўльтрамікраскапічнага метадаў вывучаны асаблівасці загойвання паўнаслойнай скурнай раны ў лабараторных пацукоў. Высветлена, што падчас загойвання на паверхні раны ўтвараюцца дзве мяжы ‒ адна па краі дэрмы, другая па краі эпідэрміса. Паказана, што грануляцыйная тканка можа фарміравацца не толькі шляхам перабудовы фібрыну, але і за кошт рэарганізацыі падскурнай клятчаткі. Вылучана гіпотэза, што кантракцыя раны адбываецца не толькі праз сцягванне калагенавых фібрыл міяфібрабластамі, але і шляхам уцягвання фібрыл у цытаплазму дадзеных клетак з наступным разбурэннем. Звяртаецца ўвага на аднаўленне эластычнай праслойкі як істотнага кампанента скурнага рэгенерата. Тлумачацца прычыны з’яўлення прадольна выцягнутай формы і арыентацыі па сагітальнай лініі шнара, які пажыццёва застаецца на месцы былога пашкоджання скуры.

A model was developed, on the basis of which the features of healing of a full-thickness skin wound were studied in laboratory rats using macro-, micro- and ultramicroscopic methods. It was found that during this process, two borders are formed on the surface of the wound ‒ one on the edge of the dermis and the second on the edge of the epidermis. It is shown that a granulation tissue can be formed not only due to the restructuring of fibrin, but also due to the reorganization of a subcutaneous tissue. It is hypothesized that the wound contraction occurs not only due to the contraction of collagen fibrils by myofibroblasts, but also due to the retraction of collagen fibers in the cytoplasm of these cells. Attention is drawn to the restoration of the elastic layer as an essential component of the skin regenerate. The reasons for the appearance of a longitudinal elongated shape and orientation along the sagittal line of the scar, which remains for life at the site of the former skin damage, are explained.

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The authors declare that there are no conflicts of interest present.