vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2022-19-2-135-150vestim-838Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEСравнительная оценка инфаркт-лимитирующей эффективности посткондиционирования с помощью лактата при ишемии-реперфузии миокарда у молодых и старых крыс и крыс с транзиторной гиперхолестеринемиейComparative evaluation of infarct-limiting efficiency of postconditioning with lactate in ischemia-reperfusion of the myocardium in young and old rats and rats with transient hypercholesterolemiaЧепелевС. Н.ChepelevS. N.

Чепелев Сергей Николаевич – старший преподаватель

пр. Дзержинского, 83, 220116, г. Минск

Sergey N. Chepelev – Senior Lecturer

83, Dzerzhinski Ave., 220116, Minsk

drserge1991@gmail.comВисмонтФ. И.VismontF. I.

Висмонт Франтишек Иванович – член-корреспондент, доктор медицинских наук, профессор, заведующий кафедрой

пр. Дзержинского, 83, 220116, г. Минск

Frantishek I. Vismont – Corresponding Member, D. Sc. (Med.), Professor, Head of the Department

83, Dzerzhinski Ave., 220116, Minsk

patfiz@bsmu.byГубкинС. В.GoubkinS. V.

Губкин Сергей Владимирович – член-корреспондент, доктор медицинских наук, профессор, директор

ул. Академическая, 28, 220072, г. Минск

Sergey V. Goubkin – Corresponding Member, D. Sc. (Med.), Professor, Director

28, Akademicheskaya Str., 220072, Minsk

goubkin@yandex.ruБелорусский государственный медицинский университетBelarusian State Medical UniversityИнститут физиологии НАН БеларусиInstitute of Physiology of the National Academy of Sciences of Belarus202208062022192135150Copyright © Чепелев С.Н., Висмонт Ф.И., Губкин С.В., 20222022Чепелев С.Н., Висмонт Ф.И., Губкин С.В.Chepelev S.N., Vismont F.I., Goubkin S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/838

Принимая во внимание высокую медицинскую и социальную значимость проблемы лечения пациентов с ишемической болезнью сердца и острым инфарктом миокарда, поиск новых эффективных методов предотвращения или ослабления ишемического и реперфузионного повреждения миокарда и выяснение механизмов их реализации является актуальной задачей современной экспериментальной и клинической медицины. Целью исследования являлось проведение сравнительного анализа и выяснение особенностей кардиопротекторной эффективности посткондиционирования (ПостК) с помощью лактата при ишемии-реперфузии миокарда у молодых и старых крыс и крыс с транзиторной гиперхолестеринемией (ГХЕ). Установлено, что дистантное ишемическое посткондиционирование (ДИПостК) при ишемии-реперфузии миокарда оказывает инфаркт-лимитирующий эффект и сопровождается повышением уровня лактата в крови, а введение в кровоток животным лактата в дозе 10 мг/кг через 25 мин после начала реперфузии приводит к уменьшению размеров зоны некроза в миокарде левого желудочка у молодых и старых крыс. Однако ПостК с помощью лактата не было эффективным в плане ограничения размеров зоны некроза в миокарде левого желудочка у молодых и старых крыс с транзиторной ГХЕ. Есть основания полагать, что гиперлактатемия имеет значимость в реализации кардиопротекторного эффекта ДИПостК. Наличие такого фактора риска сердечно-сосудистых заболеваний, как ГХЕ, может служить критерием для исключения применения ПостК с помощью лактата в качестве способа уменьшения ишемических и реперфузионных повреждений миокарда у пациентов с острым инфарктом миокарда.

 

Taking into account the high medical and social significance of the problem of treating patients with coronary heart disease and acute myocardial infarction, the search for new effective methods of preventing or weakening ischemic and reperfusion myocardial damage and finding out the mechanisms of their implementation is an urgent task of modern experimental and clinical medicine. The aim of the study was to conduct a comparative analysis and clarification of features of the cardioprotective efficiency of postconditioning with lactate in ischemia-reperfusion of the myocardium in young and old rats and rats with transient hypercholesterolemia (HCE). It was found that remote ischemic postconditioning (RIPostC) in ischemia-reperfusion of the myocardium has an infarction-limiting effect and is accompanied by an increase in the level of lactate in the blood, and lactate after injection into the bloodstream of animals at a dose of 10 mg/kg 25 min after the start of reperfusion leads to a decrease in the size of the necrosis zone in the left ventricular myocardium in young and old rats. However, postconditioning with lactate is not effective in limiting the size of the zone of necrosis in the left ventricular of myocardium in young and old rats with transient HCE. There is reason to suppose that hyperlactatemia takes part in the realization of the cardioprotective effect of RIPostC. The presence of such a risk factor for cardiovascular diseases as HCE can serve as a criterion for excluding the use of postconditioning with lactate as a way to reduce ischemic and reperfusion damage to the myocardium in patients with acute myocardial infarction.

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The authors declare that there are no conflicts of interest present.