vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2021-18-4-422-432vestim-800Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEАсаблівасці прыжыўлення і адрынання вушных алатрансплантатаў у лабараторных пацукоўFeatures of engraftment and rejection of ear alatransplants in laboratory ratsАстроўскіА. А.AstrowskiA. A.

Alexander A. Astrowski – D. Sc. (Med.), Professor, Head of the group

50, BLK, 230030, Grodno

astrowski@gmail.comРадутаА. Ф.RadutaH. F.

Helena F. Raduta – Senior Researcher

50, BLK, 230030, Grodno

elenamaria@mail.ruБакуновічА. А.BakunovichA. A.

Alexey A. Bakunovich – Junior Researcher

50, BLK, 230030, Grodno

baptist.alexei@mail.ruЯрашэнкаЮ. У.YarashenkaYu. V.

Yulia V. Yarаshenkа – Junior Researcher

50, BLK, 230030, Grodno

Julia2222@yandex.ruШурыберкаА. У.ShuryberkaA. V.

Alexey V. Shuryberka – Head of the Sector

50, BLK, 230030, Grodno

the_chemistry@tut.byШатроваВ. А.ShatrovaV. O.

Vera O. Shatrova – Lecturer

80, Gorky Str., 230009, Grodno

msbiology@mail.ruБукаВ. У.BukoV. U.

Vyacheslav U. Buko – D. Sc. (Med.), Professor

50, BLK, 230030, Grodno

vu.buko@tut.byСемяненяІ. М.SemenenyaI. N.

Igor N. Semenenya – D. Sc. (Med.), Professor, Director.

50, BLK, 230030, Grodno

insemenenya@yandex.byInstitute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of BelarusBelarusGrodno State Medical UniversityBelarus202103122021184422432Copyright © Астроўскі А.А., Радута А.Ф., Бакуновіч А.А., Ярашэнка Ю.У., Шурыберка А.У., Шатрова В.А., Бука В.У., Семяненя І.М., 20212021Астроўскі А.А., Радута А.Ф., Бакуновіч А.А., Ярашэнка Ю.У., Шурыберка А.У., Шатрова В.А., Бука В.У., Семяненя І.М.Astrowski A.A., Raduta H.F., Bakunovich A.A., Yarashenka Y.V., Shuryberka A.V., Shatrova V.O., Buko V.U., Semenenya I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/800

Распрацаваны лёгка выканальны метад выяўлення генетычнай блізкасці паміж лабараторнымі пацукамі, заснаваны на трансплантацыі вушных скурна-хандрацытарных алатрансплантатаў на паверхню паўнаслойнага скурнага дэфекту. На прыкладзе пацукоў пароды Вістар паказана, што адрынанне алатрансплантатаў пры тых генетычных адрозненнях, якія мелі месца паміж жывёламі (лабараторныя пацукі былі ўзяты з трох навукова-даследчых інстытутаў Беларусі), адбываецца пераважна на працягу 8‒21 сут. Аднак пры гэтым гінуць і адрынаюцца толькі такія структуры вушных алатрансплантатаў, як дэрма, эпідэрміс і яго вытворныя, але пласты хандрацытаў пагружаюцца пад грануляцыйную тканку і застаюцца ў жыццяздольным стане на працягу не менш за 210 сут. Апошні феномен, верагодна, абумоўлены тым, што абалонкі, якія пакрываюць хандрацыты, выконваюць функцыю імуналагічнага бар’ера.

 A method for revealing genetic affinity between laboratory rats has been developed, which is based on the transplantation of ear skin-chondrocyte allografts onto the surface of a full-thickness skin defect. On the example of Wistar rats (laboratory rats were taken from three research institutes), it was shown that the rejection of allografts occurs in the interval between 8 and 21 days with the same genetic differences that existed between the animals. However, at the same time, only those structures of ear allografts such as the dermis, epidermis and its derivatives die and are rejected, but the layers of chondrocytes are submerged under the granulation tissue and remain in a viable position for at least 210 days. The latter phenomenon is probably due to the membranes that cover the chondrocytes and act as an immunological barrier.

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The authors declare that there are no conflicts of interest present.