vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2021-18-3-340-350vestim-785Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEЭксперыментальная мадэль для ацэнкі гатоўнасці ранавай паверхні да прыняцця скурных трансплантатаўExperimental model for assessing the readiness of the wound surface to accept skin graftsБакуновічА. А.BakunovichA. A.

Бакунович Алексей Алексеевич – мл. науч. сотрудник

БЛК, 50, 230030, г. Гродно

Aliaksei A. Bakunovich – Junior Researcher

50, BLK, 230030, Grodno 

bakunovich.aliaksei@ibiochemistry.byЯрашэнкаЮ. У.YarashenkaJu. V.

Ерошенко Юлия Владимировна – мл. науч. сотрудник

БЛК, 50, 230030, г. Гродно

Juliya V. Yarashenka – Junior Researcher

50, BLK, 230030, Grodno 

julia2222@yandex.ruРадутаА. Ф.RadutaE. F.

Радута Елена Францевна – ст. науч. сотрудник

БЛК, 50, 230030, г. Гродно

Elena F. Raduta – Senior Researcher

50, BLK, 230030, Grodno 

e.raduta@ibiochemistry.byКонанаўЕ. В.KononovE. V.

Кононов Евгений Васильевич – ассистент

ул. Горького, 80, 230009, г. Гродно

Evgeny V. Kononov – Assistant

80, Gorky Str., 230009, Grodno 

kononov.eugen@gmail.comБукоВ. У.BukoV. U.

Буко Вячеслав Ульянович – д-р биол. наук, профессор, заведующий отделом

БЛК, 50, 230030, г. Гродно

Vyacheslav U. Buko – D. Sc. (Biol.), Professor, Head of the Department

50, BLK, 230030, Grodno 

vu.buko@tut.byАстроўскіА. А.AstrowskiA. A.

Островский Александр Александрович – д-р мед. наук, профессор, вед. науч. сотрудник

БЛК, 50, 230030, г. Гродно

Alexander A. Astrowski – D. Sc. (Med.), Professor, Leading Researcher

50, BLK, 230030, Grodno 

astrowski@gmail.comІнстытут біяхіміі біялагічна актыўных злучэнняў НАН БеларусіInstitute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of BelarusГродзенскі дзяржаўны медыцынскі ўніверсітэтGrodno State Medical University202106092021183340350Copyright © Бакуновіч А.А., Ярашэнка Ю.У., Радута А.Ф., Конанаў Е.В., Буко В.У., Астроўскі А.А., 20212021Бакуновіч А.А., Ярашэнка Ю.У., Радута А.Ф., Конанаў Е.В., Буко В.У., Астроўскі А.А.Bakunovich A.A., Yarashenka J.V., Raduta E.F., Kononov E.V., Buko V.U., Astrowski A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/785

Мэтай даследавання, выкананага на 65 пацуках пароды Вістар, было распрацаваць новую мадэль, каб высветліць, у якой ступені кверцэтын і нанакомплекс кверцэтын-2-гідраксіпрапіл-β-цыкладэкстрын, нанесеныя на рану, уплываюць на прыжыўляльнасць скурных аўтатрансплантатаў. Трансплантаты атрымлівалі з вушных ракавін жывёл, а іх прыжыўляльнасць ацэньвалі па ступені інгібіравання кантракцыі раны. Паказана, што апошняя залежыць ад плошчы трансплантатаў і часу, праз які яны былі размешчаны на ранавай паверхні пасля яе стварэння. Выяўлена, што кверцэтын пагаршае, а кверцэтын-2-гiдраксiпрапiл-β-цыкладэкстрын не пагаршае здольнасць ранавай паверхні прымаць трансплантаты.

The aim of the study, performed on 65 Wistar rats, was to develop a new model and, as an example, use it to identify the extent to which quercetin and the quercetin-2-hydroxypropyl-β-cyclodextrin nanocomplex, applied to the wound, affect the engraftment of skin autografts. Grafts were obtained from the ear shells of animals, and graft’s survival rate was assessed by the degree of inhibition of wound contraction. It is shown that the latter depends on the area of grafts and the time after which they were located on the wound surface after its creation. It was shown that quercetin worsens, and quercetin-2- hydroxypropyl-β-cyclodextrin does not impair the ability of the wound surface to accept the graft.

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The authors declare that there are no conflicts of interest present.