vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2021-18-1-117-126vestim-739Research ArticleОБЗОРЫREVIEWSВлияние глюкокортикоидных гормонов на функцию щитовидной железыInfluence of glucocorticoid hormones on the thyroid gland functionhttps://orcid.org/0000-0001-9150-5685ГусаковаЕ. А.GusakovaE. A.

Гусакова Елена Анатольевна – к анд. б иол. наук, доцент

пр. Фрунзе, 27, 210017, г. Витебск, Республика Беларусь

Elena A. Gusakova ‒ Ph. D. (Biol.), Associate Professor

27, Frunze Ave., 210017, Vitebsk, Republic of Belarus

elena-gusakova83@mail.ruhttps://orcid.org/0000-0002-7388-4244ГородецкаяИ. В.GorodetskayaI. V.

Городецкая Ирина Владимировна – д-р мед. наук, профессор, декан

пр. Фрунзе, 27, 210017, г. Витебск, Республика Беларусь

Irina V. Gorodetskaya ‒ D. Sc. (Med.), Professor, Dean

27, Frunze Ave., 210017, Vitebsk, Republic of Belarus

gorodeckaya-iv@mail.ruВитебский государственный ордена Дружбы народов медицинский университетVitebsk State Order of Peoples’ Friendship Medical University202123022021181117126Copyright © Гусакова Е.А., Городецкая И.В., 20212021Гусакова Е.А., Городецкая И.В.Gusakova E.A., Gorodetskaya I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/739

На основании проведенного анализа данных литературы установлено, что введение экзогенных аналогов глюкокортикоидных гормонов (кортизона, гидрокортизона, кортикостерона, дексаметазона, бетаметазона и др.) приводит к изменению тиреоидной функции на всех уровнях (биосинтеза и секреции гормонов щитовидной железой, их транспорта, взаимодействия с рецепторами в органах-мишенях, биологического действия, метаболизма и экскреции), а также к влиянию на ее регуляцию как трансгипофизарно (блокирует секрецию тиреолиберина, тиреотропного гормона, кортиколиберина, соматолиберина и продукцию соматотропного гормона под влиянием послед- него), так и парагипофизарно (стимулирует образование инсулина β-инсулоцитами поджелудочной железы).

The injection of exogenous analogues of glucocorticoid hormones (cortisone, hydrocortisone, corticosterone, dexamethasone, betamethasone, etc.) leads to a change in thyroid function at all levels (biosynthesis and secretion of hormones by the thyroid gland, the transport, interaction with receptors in target organs, biological action, their metabolism and excretion). Glucocorticoid hormones change regulationof the thyroid function: transhypophysially (glucocorticoids block the secretion of thyroliberin, thyroid stimulating hormone, corticotropin releasing hormone, somatoliberin and the production of somatotropin under the influence of the last one) and parahypophysially (glucocorticoids stimulate formation of insulin in β-cells of the pancreas).

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The authors declare that there are no conflicts of interest present.