vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2020-17-4-500-508vestim-719Research ArticleОБЗОРЫREVIEWSСовременные представления об остеогенном потенциале мезенхимальных стволовых клеток и создании биоинженерных конструкций для репарации костной тканиModern concepts of the osteogenic potential of mesenchymal stem cells and the creation of bioengineering structures for bone tissue repairЖерносеченкоА. А.ZhernasechankaH. A.

Жерносеченко Анна Александровна – научный сотрудник

ул. Фрунзенская, 43, 223053, Минский р-н, д. Боровляны

Hanna A. Zhernasechanka – Researcher

43, Frunzenskaya Str., v. Borovliany, 223053, Minsk Region

sapphire.anna@gmail.comРеспубликанский научно-практический центр детской онкологии, гематологии и иммунологииРоссияRepublican Research Center for Pediatric Oncology, Hematology and ImmunologyRussian Federation202005122020174500508Copyright © Жерносеченко А.А., 20202020Жерносеченко А.А.Zhernasechanka H.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/719

В статье суммируются современные представления об остеогенном потенциале мезенхимальных стволовых клеток (МСК) и опыте применения различных носителей для восстановления костной ткани. Понимание реализации программы остеогенеза в МСК сможет существенно расширить возможности применения этих клеток в составе биоинженерных конструкций. На сегодняшний день накоплен большой объем экспериментальных данных по изучению механизма остеогенной дифференцировки МСК, индукторов трансформации МСК в предшественники остеогенеза и созданию эквивалентов костной ткани биоинженерным путем с применением различных носителей. Особое внимание уделяется разработке материалов носителей и их проектированию, методам получения конструкций и взаимодействиям между скэффолдом и клетками, так как это имеет большое значение для дальнейшего функционирования биоинженерной ткани.

The following review summarizes the latest studies on in vitro osteogenic mesenchymal stem cell differentiation and selection of scaffolds that can maintain the viability and functional activity of these cells for bone tissue repair. In the last time, there have been investigated a lot of issues such as the stimulation and development osteogenic differentiation of MSCs, the growth factors – inducers of osteogenesis in MSCs, the creation of 3D constructions of cells in different scaffolds. A deeper understanding of the osteogenic differentiation mechanisms can result in the novel therapeutic opportunities of bone disease treatment. Special attention is given to materials for scaffold designs and template–cell interactions, which is of great importance for the structuring and functioning of an engineered tissue.

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The authors declare that there are no conflicts of interest present.