vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2020-17-1-122-128vestim-666Research ArticleОБЗОРЫREVIEWSРоль дисфункции дуктальной секреции в патогенезе хронического панкреатитаRole of the ducktal secretion dysfunction in the pathogenesis of chronic pancreatitisМожейкоЛ. А.MozheikoL. A.

Можейко Лариса Андреевна – кандидат медицинскихнаук, доцент

ул. Горького, 80, 230015, г. Гродно

Larisa A. Mozheiko – Ph. D. (Med.), Assistant professor

80, Gorky Str., 230015, Grodno

mozhhejko-hist@yandex.ruГродненский государственный медицинский университетGrodno State Medical University202018032020171122128Copyright © Можейко Л.А., 20202020Можейко Л.А.Mozheiko L.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/666

В обзоре представлен анализ современных научных сведений о роли нарушения дуктальной секреции в патогенезе хронического панкреатита. Показано, что под влиянием алкоголя или других панкреатит-провоцирующих факторов повреждается CFTR-транспортный механизм протоковых клеток, что приводит к уменьшению секреции бикарбонатов и жидкости. Дегидратация и ацидификация способствуют гиперконцентрации белкового и слизистого компонентов панкреатического секрета, изменению его реологических свойств, затруднению дальнейшего транспорта по протоковой системе. Создавшиеся условия благоприятствуют образованию слизисто-белковых пробок и обтурированию протоков, что может играть важную роль в патогенезе хронического панкреатита на ранней стадии развития заболевания.

The review presents an analysis of current scientific data on the role of ductal secretion disorders in the pathogenesis of chronic pancreatitis. It is shown that under the influence of alcohol or other provoking factors, the CFTR transport mechanism of duct cells undergoes damage, which leads to the decrease in the bicarbonate and fluid secretion. Dehydration and acidification contribute to the hyperconcentration of protein and mucous components of pancreatic secretion and to the change in its rheological properties, which complicates further transport through the ductal system. Current conditions are favorable for the formation of mucoprotein plugs and the ductal obstruction that may have an important role in the pathogenesis of chronic pancreatitis at the early stage of development of the disease.

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The authors declare that there are no conflicts of interest present.