vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2019-16-4-488-498vestim-636Research ArticleОБЗОРЫREVIEWSСаркоидоз органов дыхания: иммунопатогенетические аспекты и диагностические проблемыRespiratory sarcoidosis: immunopathogenetic aspects and diagnostic problemsСурковаЛ. К.SurkovaL. K.

Суркова Лариса Константиновна – доктор медицинских наук, профессор, заведующий отделом.

Долгиновский тракт, 157, 220053, г. Минск

Larisa K. Surkova – D. Sc. (Med.), Professor, Head of the Department. 

157, Dolginovski Tract, 220053, Minsk

niipulm@tut.byБородинаГ. Л.BorodinaG. L.

Бородина Галина Львовна – кандидат медицинских наук, доцент, заведующий кафедрой. 

пр. Дзержинского, 83, 220116, г. Минск

Galina L. Borodina – Ph. D. (Med.), Assistant Professor, Head of the Department.

83, Dzerzhinski Ave., 220116, Minsk

niipulm@tut.byШпаковскаяН. С.ShpakovskayaN. S.

Шпаковская Наталья Савельевна – кандидат биологических наук, ведущий научный сотрудник.

Долгиновский тракт, 157, 220053, г. Минск

Natalya S. Shpakovskaya – Ph. D. (Biol.), Leading researcher. 

157, Dolginovski Tract, 220053, Minsk

 

niipulm@tut.byРеспубликанский научно-практический центр пульмонологии и фтизиатрииRepublican Scientific and Practical Center for Pulmonology and TuberculosisБелорусский государственный медицинский университетBelarusian State Medical University201905122019164488498Copyright © Суркова Л.К., Бородина Г.Л., Шпаковская Н.С., 20192019Суркова Л.К., Бородина Г.Л., Шпаковская Н.С.Surkova L.K., Borodina G.L., Shpakovskaya N.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/636

Изучена проблема лечения больных саркаидозом органов дыхания на современном этапе. Рассматриваются аспекты иммунопатогенеза саркоидоза. Акцентируется внимание на вариабельности клинико-морфологических проявлений и целесообразности выделения клинико-морфологических фенотипов саркоидоза.

При дифференциальной диагностике туберкулеза и саркоидоза рекомендуется проводить комплексное исследование биоптатов, включающее морфологическое изучение и молекулярно-генетическое тестирование на микобактерии туберкулеза. Негативный результат молекулярно-генетического анализа тканевого субстрата повышает точность и достоверность морфологической верификации саркоидоза.

The analysis of the state of the problem on the sarcoidosis of the respiratory organs at the present stage has been carried out. The aspects of sarcouidosis immunopathogenesis are considered. Attention is focused on the variability of clinical and morphological manifestations and the expediency of identifying clinical and morphological phenotypes of sarcoidosis.

In the differential diagnosis of tuberculosis and sarcoidosis, a comprehensive study of biopsy specimens is recommended, including a morphological study and a molecular study for mycobacterium tuberculosis. The negative result of a molecular study of a tissue substrate improves the accuracy and reliability of morphological verification of sarcoidosis.

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The authors declare that there are no conflicts of interest present.