vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2019-16-2-192-201vestim-496Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEАссоциация полиморфных вариантов гена рецептора витамина D с показателями минеральной плотности костной ткани у женщин в менопаузеAssociation of vitamin D receptor gene polymorphism with a bone mineral density level in postmenopausal womenРуденкоЕ. В.RudenkaA. V.

Руденко Елена Викторовна – канд. мед. наук, доцент

ул. П. Бровки, 3/3, 220013, г. Минск

Alena V. Rudenka – Ph. D. (Med.), Assistant professor

3/3, P. Browka Str., 220013, Minsk

alenka.v.ru@gmail.comРуденкоЭ. В.RudenkaE. V.

Руденко Эмма Владимировна – д-р мед. наук, профессор

пр. Дзержинского, 83, 220116, г. Минск

Ema V. Rudenka – D. Sc. (Med.), Professor

83, Dzerzhinski Ave., 220116, Minsk

rudenka.ema@gmail.comСамоховецО. Ю.SamokhovecV. Yu.

Самоховец Ольга Юрьевна – канд. мед. наук, врач

Минск

Volha Yu. Samokhovec – Ph. D. (Med.), Doctor

Minsk

samokhovec.olga@gmail.comКобецЕ. В.KobetsK. V.

Кобец Екатерина Вячеславовна – мл. науч. сотрудник

ул. Академическая, 27, 220072, г. Минск

Katsiaryna V. Kobets – Junior Researcher

27, Akademicheskaya Str., 220072, Minsk

МорозикП. М.MarozikP. M.

Морозик Павел Михайлович – канд. биол. наук, доцент, вед. науч. сотрудник

ул. Академическая, 27, 220072, г. Минск

Pavel M. Marozik – Ph. D. (Med.), Assistant professor, Leading researcher

27, Akademicheskaya Str., 220072, Minsk

P.Marozik@igc.byБелорусская медицинская академия последипломного образованияBelarusian Medical Academy of Postgraduate EducationБелорусский государственный медицинский университетBelarusian State Medical UniversityМинский городской центр остеопороза и болезней костно-мышечной системыMinsk City Center for Osteoporosis and Bone-Muscular Diseases PreventionИнститут генетики и цитологии НАН БеларусиInstitute of Genetics and Cytology of the National Academy of Sciences of Belarus201901072019162192201Copyright © Руденко Е.В., Руденко Э.В., Самоховец О.Ю., Кобец Е.В., Морозик П.М., 20192019Руденко Е.В., Руденко Э.В., Самоховец О.Ю., Кобец Е.В., Морозик П.М.Rudenka A.V., Rudenka E.V., Samokhovec V.Y., Kobets K.V., Marozik P.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/496

Проанализирована взаимосвязь полиморфных вариантов гена рецептора витамина D (VDR) с показателями минеральной плотности костной ткани (МПКТ) у женщин в менопаузе. В исследование были включены 66 пациенток с постменопаузальным остеопорозом (ПМО) и 170 постменопаузальных женщин с нормальными значениями МПКТ (КОН). Выявлены различия между группами в распределении частот генотипов и аллелей для полиморфного варианта ApaI гена VDR: для лиц с генотипом C/C риск остеопороза повышен по сравнению с носителями генотипа A/A (OR = 2,7 [95 % CI: 1,5–4,7], p = 0,002). Аллель А более распространен в группе КОН и снижает риск заболевания (OR = 0,6 [95 % CI: 0,4–0,8], p = 0,001). Статистически значимые различия выявлены между исследуемыми группами при анализе распределения частот генотипов полиморфного варианта BsmI гена VDR. Среди носителей неблагоприятного генотипа G/G полиморфного варианта BsmI риск ПМО повышен по сравнению с носителями генотипа A/A (OR = 2,1 [95 % CI: 1,0–4,4], p = 0,02). Среди носителей аллеля A риск остеопороза существенно снижен (OR = 0,6 [95 % CI: 0,4–0,9], p = 0,007). МПКТ у носителей генотипа ApaI C/C на 13,7 % ниже, чем у носителей генотипа ApaI A/A (0,767 и 0,872 г/см2 соответственно, p = 0,04), а у носителей генотипа TaqI C/C – на 13,8 % ниже, чем у носителей генотипа TaqI T/T (0,803 и 0,914 г/см2 соответственно, p = 0,03). Установлено, что полиморфизм гена VDR может играть ключевую роль в предрасположенности к остеопорозу и ассоциирован с уровнем МПКТ у женщин в постменопаузе.

The analysis of association of polymorphic variants of the vitamin D receptor gene (VDR) with bone mineral density (BMD) values in menopausal women was performed. The study included 66 patients with postmenopausal osteoporosis (PMO group) and 170 postmenopausal women with normal BMD values (CON group). The statistically significant difference between the analyzed groups in the genotypes and the alleles frequency distribution for the VDR ApaI gene variant was revealed: for the carriers of C/C genotype, the risk of osteoporosis was higher compared to individuals with A/A genotype (OR = 2.7 [95 % CI: 1.5–4.7], p = 0.002). Allele A was overrepresented in the CON group and associated with the reduced risk of disease (OR = 0.6 [95 % CI: 0.4–0.8], p = 0.001). Statistically significant differences were found between the studied groups when analyzing VDR BsmI gene variant distribution. For the individuals with the unfavorable VDR BsmI G/G-genotype, the risk of PMO was significantly higher when compared to the carriers of the A/A-genotype (OR = 2.1 [95 % CI: 1.0–4.4], p = 0.02). For the bearers of A-allele, the risk of osteoporosis was significantly lower (OR = 0.6 [95 % CI: 0.4–0.9], p = 0.007). Among the carriers of the VDR ApaI C/C-genotype, the average BMD level was by 13.7 % lower compared to the carriers of the VDR ApaI A/A-genotype (0.767 and 0.872 g/cm2, respectively, p = 0.04); among individuals with the TaqI C/C-genotype, the BMD level was by 13.8 % lower compared to TaqI T/T-genotype bearers (0.803 and 0.914 g/cm2, respectively, p = 0.03). VDR gene polymorphism may play an important role in the susceptibility to osteoporosis and is significantly associated with the BMD level in postmenopausal women.

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The authors declare that there are no conflicts of interest present.