vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2019-16-1-99-107vestim-481Research ArticleОБЗОРЫREVIEWSКоррекция нарушений церебрального водного обменаCorrection of the disorders of the cerebral water metabolismТитовецЭ. П.TitovetsE. P.

Титовец Эрнст Петрович – доктор биологических наук, профессор, главный научный сотрудник

ул. Ф. Скорины, 24, 220114, г. Минск

Ernst P. Titovets – D. Sc. (Biol.), Professor, Chief researcher

24, Fr. Skoriny Str., 220114, Minsk

eptitovets@gmail.comСмеяновичА. Ф.SmeyanovichA. F.

Смеянович Арнольд Федорович – академик, доктор медицинских наук, профессор

ул. Ф. Скорины, 24, 220114, г. Минск

Arnold F. Smeyanovich – Academician, D. Sc. (Med.), Professor

24, Fr. Skoriny Str., 220114, Minsk

niinh@mail.ruКозичП. В.KozichP. V.

Козич Павел Валерьевич – врач анестезиолог-реаниматолог, заведующий отделением

ул. Ф. Скорины, 24, 220114, г. Минск

Pavel V. Kozich – anesthesiologist-resuscitator, Head of the Department

24, Fr. Skoriny Str., 220114, Minsk

pvkozich@gmail.comРеспубликанский научно-практический центр неврологии и нейрохирургииRepublican Scientifc and Practical Center for Neurology and Neurosurgery20191203201916199107Copyright © Титовец Э.П., Смеянович А.Ф., Козич П.В., 20192019Титовец Э.П., Смеянович А.Ф., Козич П.В.Titovets E.P., Smeyanovich A.F., Kozich P.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/481

Описан механизм церебрального водного обмена, в реализации которого принимает участие главный аквапорин головного мозга (ГМ) – AQP4. Этот аквапорин определяет скорость переноса воды через гематоэнцефалический барьер и ее обмен между паренхимой ГМ и цереброспинальной жидкостью. В мировой литературе AQP4 рассматривается как молекулярное звено воздействия лекарственных средств на водный обмен тканей ГМ. В свете новых знаний рассмотрены принципиальные подходы к оптимизации способов фармакологической коррекции нарушений церебрального водного обмена и борьбы с отеками ГМ.

The new information, that has become available at present, makes it possible to outline a mechanism of brain water metabolism in the realization of which an important role belongs to AQP4, the main aquaporin of the brain. This aquaporin controls water transfer across the blood-brain barrier and water exchange between brain parenchyma and the cerebrospinal fluid. In the world literature, AQP4 is viewed as a molecular target for the drug action directed at correction of the brain water metabolism disorders in pathologies. The new knowledge made it possible to outline principal approaches to pharmacological correction of cerebral water metabolism disorders and edema.

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The authors declare that there are no conflicts of interest present.