vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2019-16-1-35-45vestim-474Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEГенетические варианты парвовируса B19, циркулирующие в Беларуси в течение эпидемического цикла инфекции (2005–2016)Genetic variants of parvovirus B19 circulating in Belarus during the epidemic cycle of infection (2005–2016)ЕрмоловичМ. А.YermalovichM. A.

Ермолович Марина Анатольевна – кандидат медицинских наук, ведущий научный сотрудник

ул. Филимонова, 23, 220114, г. Минск

Marina A. Yermalovich – Ph. D. (Med.), Leading researcher

23, Filimonov Str., 220114, Minsk

yermalovich@mail.ruСемейкоГ. В.SemeikoG. V.

Семейко Галина Валерьевна – кандидат биологических наук, ведущий научный сотрудник

ул. Филимонова, 23, 220114, г. Минск

Galina V. Semeiko – Ph. D. (Biol.), Leading researcher

23, Filimonov Str., 220114, Minsk

g-semeiko@yandex.ruСамойловичЕ. О.SamoilovichE. O.

Самойлович Елена Олеговна – доктор медицинских наук, профессор, заведующий лабораторией

ул. Филимонова, 23, 220114, г. Минск

Elena O. Samoilovich – D. Sc. (Med.), Professor, Head of the Laboratory

23, Filimonov Str., 220114, Minsk

esamoilovich@gmail.comРеспубликанский научно-практический центр эпидемиологии и микробиологииRepublican Research and Practical Center for Epidemiology and Microbiology2019120320191613545Copyright © Ермолович М.А., Семейко Г.В., Самойлович Е.О., 20192019Ермолович М.А., Семейко Г.В., Самойлович Е.О.Yermalovich M.A., Semeiko G.V., Samoilovich E.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/474

Парвовирусная инфекция человека характеризуется разнообразием клинических проявлений. На основании генетического анализа у парвовируса В19 выделяют генотипы 1a, 1b, 2, 3a, 3b, которые имеют различное территориальное распространение. В период 2005–2016 гг. в Беларуси было генотипировано 210 парвовирусов В19, полученных из сыворотки крови пациентов с разными формами парвовирусной инфекции, преимущественно инфекционной эритемы. Все вирусы, за исключением одного, принадлежали к генотипу 1а. Один вирус относился к генотипу 3b и был выделен от ребенка с апластическим кризом, прибывшего в Беларусь из Казахстана на лечение. Штаммы генотипа 1а на филогенетическом древе формировали две группы, относящиеся к субтипам 1а1 и 1а2. В течение 12 лет наблюдения на территории страны циркулировали оба субтипа, однако с разной интенсивностью. В годы наиболее высокой заболеваемости, а также один-два года до и после эпидемического подъема (2005–2008 и 2013–2016) в циркуляции преобладали парвовирусы субтипа 1а2. В период низкой заболеваемости (2009–2012) доминирующее положение занимал субтип 1а1. Среднее генетическое расстояние внутри субтипа составляло 0,51 % для 1а1 и 0,56 % для 1а2, между субтипами оно также было небольшим – 1,32 %. Можно предположить, что субтип 1а2 является более новым для Беларуси, вследствие чего имеет большее эпидемическое значение в настоящее время.

Human parvovirus infection is characterized by a variety of clinical manifestations. Based on the genetic analysis, genotypes 1a, 1b, 2, 3a, 3b of parvovirus B19 are distinguished, which have different geographical distribution. In the period 2005–2016, in Belarus 210 strains of parvovirus B19 isolated from the patients with various forms of parvovirus infection, mainly erythema infectiosum, were genotyped. All strains, except one, belonged to genotype 1a. One strain belonged to genotype 3b and was isolated from a child with aplastic crisis who arrived in Belarus from Kazakhstan for medical care. On the phylogenetic tree, the strains of genotype 1a formed two groups related to the subtypes 1a1 and 1a2. During the 12-year observation, both subtypes circulated in Belarus, but with varying intensity. In the highest incidence years, as well as one or two years before and after this (2005–2008 and 2013–2016), strains of subtype 1a2 predominated in circulation. During the period of low incidence (2009–2012), the dominant position belonged to subtype 1a1. The average genetic distance inside each subtype was 0.51 % for 1a1 and 0.56 % for 1a2. Between subtypes it was also small – 1.32 %. It can be assumed that subtype 1a2 is more new for Belarus and therefore might be connected with the increase of morbidity.

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The authors declare that there are no conflicts of interest present.