vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2018-15-4-483-492vestim-462Research ArticleОБЗОРЫREVIEWSРегуляторный и терапевтический потенциал при ожиренииRegulatory and therapeutic potential for obesityПолуляхО. Е.PoluliakhO. E.

науч. сотрудник

Researcher

reanzy@yandex.ruКалиновскаяЕ. И.KalinovskayaE. I.

канд. мед. наук, заведующий лабораторией

Ph. D. (Med), Head of the Laboratory

zolotuhinaelena@mail.ruБасалайА. А.BasalaiA. A.

мл. науч. сотрудник

Junior researcher

anastasiya.basalay@gmail.comИнститут физиологии НАН Беларуси, МинскInstitute of Physiology of the National Academy of Sciences of Belarus, Minsk201814012019154483492Copyright © Полулях О.Е., Калиновская Е.И., Басалай А.А., 20192019Полулях О.Е., Калиновская Е.И., Басалай А.А.Poluliakh O.E., Kalinovskaya E.I., Basalai A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/462

Приведен обзор литературных данных о роли микроРНК в биологических процессах, ассоциированных с развитием ожирения. Описаны современные представления о микроРНК, их биогенезе и функции в образовании жировой ткани, метаболизме липидов и углеводов. Рассмотрены возможности использования микроРНК для разработки новых терапевтических подходов в лечении ожирения и связанных с ним осложнений, а также в качестве биомаркеров различных патологических процессов, обусловленных нарушением обмена веществ в организме.

A literature review about the role of microrna in biological processes associated with .obesity was completed. Modern ideas about micrornas, their biogenesis and their role in the formation of adipose tissue, glucose and lipid metabolism were described. The possibilities of using microRNA as new biomarkers and therapeutic targets for development of anti-obesity drugs were considered.

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The authors declare that there are no conflicts of interest present.