vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2018-15-3-363-382vestim-445Research ArticleОБЗОРЫREVIEWSМОНОЦИТЫ, МАКРОФАГИ, ДЕНДРИТНЫЕ И МИЕЛОИДНЫЕ СУПРЕССОРНЫЕ КЛЕТКИ: ГЕНЕЗ, КЛАССИФИКАЦИЯ, ИММУНОБИОЛОГИЧЕСКИЕ СВОЙСТВАMONOCYTES, MACROPHAGES, DENDRITIC AND MYELOID SUPPRESSOR CELLS: GENESIS, CLASSIFICATION, IMMUNOBIOLOGICAL PROPERTIESТитовЛ. П.TitovL. P.

Титов Леонид Петрович – член-корреспондент, д-р мед. наук, профессор

ул. Филимонова, 23, 220114, г. Минск

Leonid P. Titov – Corresponding Member, D. Sc. (Med.), Professor

23, Filimonov Str., 220114, Minsk

leotit310@gmail.comРеспубликанский научно-практический центр эпидемиологии и микробиологииRepublican Scientific and Practical Center for Epidemiology and Microbiology201816092018153363382Copyright © Титов Л.П., 20182018Титов Л.П.Titov L.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/445

В статье представлены современные данные о важнейшем компоненте естественного иммунитета человека – клетках системы мононуклеарных фагоцитов. Рассмотрены такие вопросы, как происхождение, репертуар экспрессируемых дифференцировочных маркеров, классификация моноцитов (классические, промежуточные, неклассические), макрофагов (провоспалительные и противовоспалительные) и дендритных клеток (миелоидные, плазмацитоидные), их иммунобиологические функции, роль в гуморальном и Т-клеточном иммунном ответе. Анализируется возможность получения клеточных иммунобиологических продуктов (адъювантных/стимуляторных и толерогенных) для иммунотерапии онкологических, инфекционных и аутоиммунных заболеваний.

The article presents the modern data on the most important component of natural immunity – cells of the mononuclear phagocyte system. The questions of origin, the spectrum of expressed markers of differentiation, the classification of monocytes (classical, intermediate, non-classical), macrophages (pro-inflammatory and anti-inflammatory) and dendritic cells (myeloid, plasmacytoid), their immunobiological functions, their role in humoral and T-cell immune responses, anergy and tolerance are considered. The possibility of obtaining cellular immunobiological products (adjuvant and tolerogenic) for immunotherapy of oncological, infectious and autoimmune diseases on their basis is analyzed.

моноцитымакрофагимиелоидные и плазмацитоидные дендритные клеткивоспалениеиммунный ответmonocytesmacrophagesmyeloid and plasmacytoid dendritic cellsinflammationimmune responseReferencesТитов, Л. П. Медицинская геномика: организация генома, регуляция экспрессии генов, генетическая вариабельность / Л. П. Титов // Вес. Нац. aкад. навук Беларусі. Сер. мед. навук. – 2015. – № 4. – С. 97–113.Titov L. P. Medical genomics: human genome organization, gene expression regulation and genetic variability. Vestsi Natsyyanal’nai akademii navuk Belarusi. Seryya medytsynskikh navuk = Proceedings of the National Academy of Sciences of Belarus. Medical series, 2015, no. 4, pp. 97–113 (in Russian).Defining “mutation” and “polymorphism” in the era of personal genomics / R. Karki [et al.] // BMC Med. Genomics. – 2015. – Vol. 8, N 37. – 7 p. https://doi.org/10.1186/s12920-015-0115-zKarki R., Pandya D., Elston R. C., Ferlini Cr. Defining “mutation” and “polymorphism” in the era of personal genomics. BMC Medical Genomics, 2015, vol. 8, no. 37. 7 p. https://doi.org/10.1186/s12920-015-0115-zCell components in the immune response: II. Cell attachment separation of immune cells / K. Hartmann [et al.] // Cell. Immunol. – 1970. – Vol. 1, N 2. – P. 182–189. https://doi.org/10.1016/0008-8749(70)90005-5Hartmann K., Dutton R. W., McCarthy M. M., Mishel R. I. Cell components in the immune response: II. Cell attachment separation of immune cells. Cellular Immunology, 1970, vol. 1, no. 2, pp. 182–189. https://doi.org/10.1016/0008- 8749(70)90005-5Pierce, C. W. Requirement for macrophages in primary and secondary humoral responses / C. W. Pierce // Immunology / ed. : J. A. Bellanti, H. B. Herscowitz. – Boston, 1984. – P. 157–171.Pierce C. W. Requirement for macrophages in primary and secondary humoral responses. Immunology. Boston, 1984, pp. 157–171.Burnet, F. M. A modification of Jerne’s theory of antibody production using the concept of clonal selection / F. M. Burnet // CA: A Cancer J. for Clinicians. – 1976. – Vol. 26, N 2. – P. 119–121. https://doi.org/10.3322/canjclin.26.2.119Burnet F. M. A modification of Jerne’s theory of antibody production using the concept of clonal selection. CA: A Cancer Journal for Clinicians, 1976, vol. 26, no. 2, pp. 119–121. https://doi.org/10.3322/canjclin.26.2.119Metchnikoff, É. Immunity in the infectious diseases / É. Metchnikoff. – Cambridge : Cambridge Univ. Press, 1905. – 617 p.Metchnikoff É. Immunity in infectious diseases. Cambridge, Cambridge University Press, 1905. 617 p.Furth van, R. The origin and kinetics of mononuclear phagocytes / R. van Furth, Z. A. Cohn // J. Exp. Med. – 1968. – Vol. 128, N 3. – P. 415–435. https://doi.org/10.1084/jem.128.3.415Furth van R., Cohn Z. A. The origin and kinetics of mononuclear phagocytes. Journal of Experimental Medicine, 1968, vol. 128, no. 3, pp. 415–435. https://doi.org/10.1084/jem.128.3.415The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells / R. van Furth [et al.] // Bull. of the World Health Organization. – 1972. – Vol. 46, N 6. – P. 845–852.Furth van R., Cohn Z. A., Hirsch J. G., Humphrey J. H., Spector W. G., Langevoort H. L. The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells. Bulletin of the World Health Organization, 1972, vol. 46, no. 6, pp. 845–852.Steinman, R. M. Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro / R. M. Steinman, Z. A. Cohn // J. Exp. Med. – 1974. – Vol. 39, N 2. – P. 380–397. https://doi.org/10.1084/jem.139.2.380Steinman R. M., Cohn Z. A. Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. Journal of Experimental Medicine, 1974, vol. 39, no. 2, pp. 380–397. https://doi.org/10.1084/jem.139.2.380Mildner, A. Development and function of dendritic cell subsets / A. Mildner, S. Jung // Immunity. – 2014. – Vol. 40, N 5. – P. 642–656. https://doi.org/10.1016/j.immuni.2014.04.016Mildner A., Jung S. Development and function of dendritic cell subsets. Immunity, 2014, vol. 40, no. 5, pp. 642–656. https://doi.org/10.1016/j.immuni.2014.04.016Taylor, P. R. Monocyte heterogeneity and innate immunity / P. R. Taylor, S. Gordon // Immunity. – 2003. – Vol. 19, N 1. – P. 2–4. https://doi.org/10.1016/S1074-7613(03)00178-XTaylor P. R., Gordon S. Monocyte heterogeneity and innate immunity. Immunity, 2003, vol. 19, no. 1, pp. 2–4. https:// doi.org/10.1016/S1074-7613(03)00178-XSabado, R. L. Dendritic cell-based immunotherapy / R. L. Sabado, S. Balan, N. Bhardwaj // Cell Res. – 2017. – Vol. 27, N 1. – P. 74–95. https://doi.org/10.1038/cr.2016.157Sabado R. L., Balan S., Bhardwaj N. Dendritic cell-based immunotherapy. Cell Research, 2017, vol. 27, no. 1, pp. 74–95. https://doi.org/10.1038/cr.2016.157Cybulsky, M. I. Macrophages and dendritic cells: partners in atherogenesis / M. I. Cybulsky, C. Cheong, C. S. Robbins // Circ. Res. – 2016. – Vol. 118, N 4. – P. 637–652. https://doi.org/10.1161/CIRCRESAHA.115.306542Cybulsky M. I., Cheong C., Robbins C. S. Macrophages and Dendritic Cells: Partners in Atherogenesis. Circulation Research, 2016, vol. 118, no. 4, pp. 637–652. https://doi.org/10.1161/CIRCRESAHA.115.306542Differentiation of human monocytes and derived subsets of macrophages and dendritic cells by the HLDA10 monoclonal antibody panel / A. Ohradanova-Repic [et al.] // Clin. Transl. Immunol. – 2016. – Vol. 5, N 1. – P. e55. https://doi. org/10.1038/cti.2015.39Ohradanova-Repic A., Machacek C., Fischer M. B., Stockinger H. Differentiation of human monocytes and derived subsets of macrophages and dendritic cells by the HLDA10 monoclonal antibody panel. Clinical and Translational Immunology, 2016, vol. 5, no. 1, p. e55. https://doi.org/10.1038/cti.2015.39Влияние лекарственных средств на лабораторные показатели : учеб. пособие / О. И. Залюбовская [и др.]. – Харьков : Нац. фармацевт. ун-т, 2010. – 84 с.Zalyubovskaya O. I., Zlenko V. V., Bereznyakova M. E., Litvinova O. N., Fomina G. P. Effect of medicines on laboratory parameters. Textbook for students of medical and pharmaceutical universities. Kharkov, Publishing house of the National Pharmaceutical University, 2010. 84 p. (in Russian).Italiani, P. From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation / P. Italiani, D. Boraschi // Front. Immunol. – 2014. – Vol. 5. – Art. 514. https://doi.org/10.3389/fimmu.2014.00514Italiani P., Boraschi D. From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation. Frontiers in Immunology, 2014, vol. 5, art. 514. https://doi.org/10.3389/fimmu.2014.00514Unravelling mononuclear phagocyte heterogeneity / F. Geissman [et al.] // Nat. Rev. Immunol. – 2010. – Vol. 10, N 6. – P. 453–460. https://doi.org/10.1038/nri2784Geissman F., Gordon S., Hume D. A., Mowat A. M., Randolph G. J. Unravelling mononuclear phagocyte heterogeneity. Nature Reviews Immunology, 2010, vol. 10, no. 6, pp. 453–460. https://doi.org/10.1038/nri2784Jenkins, S. J. Homeostasis in the mononuclear phagocyte system / S. J. Jenkins, D. A. Hume // Trends Immunol. – 2014. – Vol. 35, N 8. – P. 358–367. https://doi.org/10.1016/j.it.2014.06.006Jenkins S. J., Hume D. A. Homeostasis in the mononuclear phagocyte system. Trends in Immunology, 2014, vol. 35, no. 8, pp. 358–367. https://doi.org/10.1016/j.it.2014.06.006Monocytes and macrophages in flow: an ESCCA initiative on advanced analyses of monocyte lineage using flow cytometry / C. Lambert [et al.] // Cytometry. Pt. B: Clinical Cytometry. – 2017. – Vol. 92, N 3. – P. 180–188. https://doi. org/10.1002/cyto.b.21280Lambert C., Preijers F. W. M. B., Yanikkaya Demirel G., Sack U. Monocytes and macrophages in flow: an ESCCA initiative on advanced analyses of monocyte lineage using flow cytometry. Cytometry. Part B: Clinical Cytometry, 2017, vol. 92, no. 3, pp. 180–188. https://doi.org/10.1002/cyto.b.21280Expansion and differentiation of CD14+CD16– and CD14++CD16+ human monocyte subsets from cord blood CD34+ hematopoietic progenitors / M. Stec [et al.] // J. Leukoc. Biol. – 2007. – Vol. 82, N 3. – P. 594–602. https://doi.org/10.1189/ jlb.0207117Stec M., Weglarczyk K., Baran J., Zuba E., Mytar B., Pryjma J., Zembala M. Expansion and differentiation of CD14+CD16– and CD14++CD16+ human monocyte subsets from cord blood CD34+ hematopoietic progenitors. Journal of Leukocyte Biology, 2007, vol. 82, no. 3, pp. 594–602. https://doi.org/10.1189/jlb.0207117Gerhardt, T. Monocyte trafficking across the vessel wall / T. Gerhardt, K. Ley // Cardiovasc. Res. – 2015. – Vol. 107, N 3. – P. 321–330. https://doi.org/10.1093/cvr/cvv147Gerhardt T., Ley K. Monocyte trafficking across the vessel wall. Cardiovascular Research, 2015, vol. 107, no. 3, pp. 321–330. https://doi.org/10.1093/cvr/cvv147Elevated CD14++CD16– monocytes predict cardiovascular events / K. E. Berg [et al.] // Circulation: Cardiovascular Genetics. – 2012. – Vol. 5, N 1. – P. 122–131. https://doi.org/10.1161/CIRCGENETICS.111.960385Berg K. E., Ljungcrantz I., Andersson L., Bryngelsson C., Hedblad B., Fredrikson G. N., Nilsson J., Björkbacka H. Elevated CD14++CD16– monocytes predict cardiovascular events. Circulation. Cardiovascular Genetics, 2012, vol. 5, no. 1, pp. 122–131. https://doi.org/10.1161/CIRCGENETICS.111.960385Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases / J. Yang [et al.] // Biomarker Res. – 2014. – Vol. 2, N 1. – 9 p. https://doi.org/10.1186/2050-7771-2-1Yang J., Zhang L., Yu. C., Yang X.-F., Wang H. Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases. Biomarker Research, 2014, vol. 2, no. 1. 9 p. https://doi.org/10.1186/2050- 7771-2-1Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16– monocyte subsets / P. Ancuta [et al.] // BMC Genomics. – 2009. – Vol. 10, N 1. – Art. 403. https://doi.org/10.1186/1471-2164-10-403Ancuta P., Liu K.-Y., Misra V., Wacleche V. S., Gosselin A., Zhou X., Gabuzda D. Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16– monocyte subsets. BMC Genomics, 2009, vol. 10, no. 1, art. 403. https://doi.org/10.1186/1471-2164-10-403Williams Hematology / K. Kaushansky [et al.]. – 9th ed. – New York : McGraw-Hill Education, 2016. – 2528 p.Kaushansky K., Lichtman M. A., Prchal J. T., Levi M. M., Press O. W., Burns L. J., Caligiuri M. Williams Hematology. 9th ed. New York, McGraw-Hill Education, 2016. 2528 p.Chernoshey, D. A. Anergy to mycobacterial antigens in lung cancer patients. Abstracts of 8th European Congress on Clinical Microbiology & Infectious Diseases, Lausanne, Switzerland, 25–28 May, 1997 / D. A. Chernoshey, L. P. Titov // Eur. J. Clin. Microbiol. Infect. Dis. – 1997. – Vol. 3, suppl. 2. – P. 344.Chernoshey D. A., Titov L. P. Anergy to mycobacterial antigens in lung cancer patients. Abstracts of 8th European Congress on Clinical Microbiology & Infectious Diseases, Lausanne, Switzerland, 25–28 May, 1997. European Journal of Clinical Microbiology and Infectious Diseases, 1997, vol. 3, suppl. 2. p. 344.Титов, Л. П. О взаимосвязи между активностью комплемента и моноцитарной реакцией / Л. П. Титов // Проблемы туберкулеза. – 1978. – Т. 56, № 6. – С. 64–69.Titov L. P. On interrelation between complement activity and monocytic reaction. Problemy tuberkuleza [Problems of tuberculosis], 1978, vol. 56, no. 6, pp. 64–69 (in Russian).Титов, Л. П. Исследование связи между пробой Манту имоноцит-комплементарным индексом у больных туберкулезом легких / Л. П. Титов // Вопросы иммунологии : респ. межвед. сб. науч. работ / редкол. : Л. Г. Борткевич [и др.]. – Минск, 1979. – С. 55–59.Titov L. P. Mantoux test and monocyte-complementary index in patients with pulmonary tuberculosis. Voprosy immunologii: respublikanskii mezhvedomstvennyi sbornik nauchnykh rabot [Immunology questions: republican interdepartmental collection of scientific works]. Minsk, 1979, pp. 55–59 (in Russian).Титов, Л. П. Моноцит-комплементарный индекс при заболеваниях инфекционной и неинфекционной этиологии / Л. П. Титов // Здравоохранение Белоруссии. – 1989. – № 2. – С. 28–31.Titov L. P. Monocyte-complementary index for diseases of infectious and non-infectious etiology. Zdravookhranenie Belorussii [Health Care in Belarus], 1989, no. 2, pp. 28–31 (in Russian).Полукчи, О. К. Моноцит-комплементарний iндекс у хворих на дифтерiю / О. К. Полукчи // Вiсн. Харк. нац. ун-та им. В. Н. Каразина. Сер. Медицина. – 2002. – № 4 (546). – С. 66–68.Polykchi A. K. Monocyte-complementary index in patient with dyphteria. Visnyk Harkivs’kogo nacional’nogo universytetu imeni V. N. Karazina. Seriya Meditsina [Bulletin of Kharkov National University named after V. N. Karazin. Series Medicine], 2002, no. 4 (546), pp. 66–68 (in Ukrainian).Doshi, N. Macrophages recognizesize and shape of their targets / N. Doshi, S. Mitragotri // PLoS One. – 2010. – Vol. 5, N 4. – P. e10051. https://doi.org/10.1371/journal.pone.0010051Doshi N., Mitragotri S. Macrophages recognize size and shape of their targets. PLoS One, 2010, vol. 5, no. 4, p. e10051. https://doi.org/10.1371/journal.pone.0010051Ginhoux, F. Monocytes and macrophages: developmental pathways and tissue homeostasis / F. Ginhoux, S. Jung // Nat. Rev. Immunol. – 2014. – Vol. 14, N 6. – P. 392–404. https://doi.org/10.1038/nri3671Ginhoux F., Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nature Reviews Immunology, 2014, vol. 14, no. 6, pp. 392–404. https://doi.org/10.1038/nri3671Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors / E. Gomez Perdiguero [et al.] // Nature. – 2015. – Vol. 518, N 7540. – P. 547–551. https://doi.org/10.1038/nature13989Gomez Perdiguero E., Klapproth K., Schulz C., Busch K., Azzoni E., Crozet L., Garner H., Trouillet C., de Bruijn M. F., Geissmann F., Rodewald H.-R. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature, 2015, vol. 518, no. 7540, pp. 547–551. https://doi.org/10.1038/nature13989Epelman, S. Origin and functions of tissue macrophages / S. Epelman, K. J. Lavine, G. J. Randolph // Immunity. – 2014. – Vol. 41, N 1. – P. 21–35. https://doi.org/10.1016/j.immuni.2014.06.013Epelman S., Lavine K. J., Randolph G. J. Origin and functions of tissue macrophages. Immunity, 2014, vol. 41, no. 1, pp. 21–35. https://doi.org/10.1016/j.immuni.2014.06.013Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? / B. Reizis [et al.] // Nat. Rev. Immunol. – 2011. – Vol. 11, N 8. – P. 558–565. https://doi.org/10.1038/nri3027Reizis B., Colonna M., Trinchieri G., Barrat F., Gilliet M. Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Nature Reviews Immunology, 2011, vol. 11, no. 8, pp. 558–565. https://doi.org/10.1038/nri3027Steimann, R. M. Decisions about dendritic cells: past, present, and future / R. M. Steimann // Annu. Rev. Immunol. – 2012. – Vol. 30, N 1. – P. 1–22. https://doi.org/10.1146/annurev-immunol-100311-102839Steimann R. M. Decisions about dendritic cells: past, present, and future. Annual Review of Immunology, 2012, vol. 30, no. 1, pp. 1–22. https://doi.org/10.1146/annurev-immunol-100311-102839Gene-expression profiles and transcriptional regulatory pathways underlying mouse tissue macrophage identity and diversity of mouse tissue macrophages / E. L. Gautier [et al.] // Nat. Immunol. – 2012. – Vol. 13, N 11. – P. 1118–1128. https:// doi.org/10.1038/ni.2419Gautier E. L., Shay T., Miller J., Greter M., Jakubzick C., Ivanov S., Helft J., Chow A., Elpek K. G., Gordonov S., Mazloom A. R., Ma’ayan A., Chua W. J., Hansen T. H., Turley S. J., Merad M., Randolph G. J. Gene-expression profiles and transcriptional regulatory pathways underlying mouse tissue macrophage identity and diversity of mouse tissue macrophages. Nature Immunology, 2012, vol. 13, no. 11, pp. 1118–1128. https://doi.org/10.1038/ni.2419The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency / V. Bigley [et al.] // J. Exp. Med. – 2011. – Vol. 208, N 2. – P. 227–234. https://doi.org/10.1084/jem.20101459Bigley V., Haniffa M., Doulatov S., Wang X. N., Dickinson R., McGovern N., Jardine L., Pagan S., Dimmick I., Chua I., Wallis J., Lordan J., Morgan C., Kumararatne D. S., Doffinger R., vanderBurg M., van Dongen J., Cant A., Dick J. E., Hambleton S., Collin M. The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. Journal of Experimental Medicine, 2011, vol. 208, no. 2, pp. 227–234. https://doi.org/10.1084/jem.20101459Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes/ D. Hashimoto [et al.] // Immunity. – 2013. – Vol. 38, N 4. – P. 792–804. https://doi.org/10.1016/j.immuni.2013.04.004Hashimoto D., Chow A., Noizat C., Teo P., Beasley M. B., Leboeuf M., Becker C. D., See P., Price J., Lucas D., Greter M., Mortha A., Boyer S. W., Forsberg E. C., Tanaka M., vanRooijen N., García-Sastre A., Stanley E. R., Ginhoux F., Frenette P. S., Merad M. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity, 2013, vol. 38, no. 4, pp. 792–804. https://doi.org/10.1016/j.immuni.2013.04.004Wynn, T. A. Macrophage biology in development, homeostasis and disease / T. A. Wynn, A. Chawla, J. W. Pollard // Nature. – 2013. – Vol. 496, N 7446. – P. 445–455. https://doi.org/10.1038/nature12034Wynn T. A., Chawla A., Pollard J. W. Macrophage biology in development, homeostasis and disease. Nature, 2013, vol. 496, no. 7446, pp. 445–455. https://doi.org/10.1038/nature12034Mosser, D. M. Exploring the full spectrum of macrophage activation / D. M. Mosser, J. P. Edwards // Nat. Rev. Immunol. – 2008. – Vol. 8, N 12. – P. 958–969. https://doi.org/10.1038/nri2448Mosser D. M., Edwards J. P. Exploring the full spectrum of macrophage activation. Nature Reviews Immunology, 2008, vol. 8, no. 12, pp. 958–969. https://doi.org/10.1038/nri2448Fraternale, A. Polarization and repolarization of macrophages / A. Fraternale, S. Brundu, M. Magnani // J. Clin. Cell. Immunol. – 2015. – Vol. 6, N 2. – P. e319. https://doi.org/10.4172/2155-9899.1000319Fraternale A., Brundu S., Magnani M. Polarization and repolarization of macrophages. Journal of Clinical and Cellular Immunology, 2015, vol. 6, no. 2, p. e319. https://doi.org/10.4172/2155-9899.1000319Modulation of macrophage phenotype by cell shape / F. Y. McWhorter [et al.] // Proc. Natl. Acad. Sci. – 2013. – Vol. 110, N 43. – P. 17253–17258. https://doi.org/10.1073/pnas.1308887110McWhorter F. Y., Wang T., Nguyen P., Chung T., Liu W. F. Modulation of macrophage phenotype by cell shape. Proceedings of the National Academy of Sciences, 2013, vol. 110, no. 43, pp. 17253–17258. https://doi.org/10.1073/ pnas.1308887110M-1/M-2 macrophages and the Th1/Th2 paradigm / C. D. Mills [et al.] // J. Immunol. – 2000. – Vol. 164, N 12. – P. 6166–6173. https://doi.org/10.4049/jimmunol.164.12.6166Mills C. D., Kincaid K., Alt J. M., Heilman M. J., Hill A. M. M-1/M-2 macrophages and the Th1/Th2 paradigm. Journal of Immunology, 2000, vol. 164, no. 12, pp. 6166–6173. https://doi.org/10.4049/jimmunol.164.12.6166Macrophage polarization in inflammatory diseases / Y.-C. Liu [et al.] // Int. J. Biol. Sci. – 2014. – Vol. 10, N 5. – P. 520–529. https://doi.org/10.7150/ijbs.8879Liu Y.-C., Zou X.-B., Chai Y.-F., Yao Y.-M. Macrophage polarization in inflammatory diseases. International Journal of Biological Sciences, 2014, vol. 10, no. 5, pp. 520–529. https://doi.org/10.7150/ijbs.8879Rőszer, T. Understanding the mysterious M2 macrophage through activation markers and effector mechanisms / T. Rőszer // Mediators of Inflammation. – 2015. – Vol. 2015. – Art. 816460. https://doi.org/10.1155/2015/816460Rőszer T. Understanding the mysterious M2 macrophage through activation markers and effector mechanisms. Mediators of Inflammation, 2015, vol. 2015, art. 816460. https://doi.org/10.1155/2015/816460Титов, Л. П. Введение в иммунологию. Иммунокомпетентные клетки / Л. П. Титов // Медицина. – 1997. – № 3. – С. 34–35.Titov L. P. Introduction to immunology. Immunocompetent cells. Meditsina = Medicine, 1997, no. 3, pp. 34–35 (in Russian).The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways / F. Ishikawa [et al.] // Blood. – 2007. – Vol. 110, N 10. – P. 3591–3660. https://doi.org/10.1182/blood-2007-02-071613Ishikawa F., Niiro H., Iino T., Yoshida S., Saito N., Onohara S., Miyamoto T., Minagawa H., Fujii S., Shultz L. D., Harada M., Akashi K. The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Blood, 2007, vol. 110, no. 10, pp. 3591–3660. https://doi.org/10.1182/blood-2007-02-071613Basta, S. The cross-priming pathway: a portrait of an intricate immune system / S. Basta, A. Alatery // Scand. J. Immunol. – 2007. – Vol. 65, N 4. – P. 311–319. https://doi.org/10.1111/j.1365-3083.2007.01909.xBasta S., Alatery A. The cross-priming pathway: a portrait of an intricate immune system. Scandinavian Journal of Immunology, 2007, vol. 65, no. 4, pp. 311–319. https://doi.org/10.1111/j.1365-3083.2007.01909.xQuantitative and functional differences between peripheral blood myeloid dendritic cells from patients with pleural and parenchymal lung tuberculosis / M. Mendelson [et al.] // Clin. Vaccine Immunol. – 2006. – Vol. 13, N 12. – P. 1299–1306. https://doi.org/10.1128/CVI.00132-06Mendelson M., Hanekom W. A., Ntutela S., Vogt M., Steyn L., Maartens G., Kaplan G. Quantitative and functional differences between peripheral blood myeloid dendritic cells from patients with pleural and parenchymal lung tuberculosis. Clinical and Vaccine Immunology, 2006, vol. 13, no. 12, pp. 1299–1306. https://doi.org/10.1128/CVI.00132-06Martín-Fontecha, A. Dendritic cell migration to peripheral lymph nodes / A. Martín-Fontecha, A. Lanzavecchia, F. Sallusto // Dendritic Cells / ed. : G. Lombardi, Y. Riffo-Vasquez. – Berlin, 2009. – P. 31–49.Martín-Fontecha A., Lanzavecchia A., Sallusto F. Dendritic cell migration to peripheral lymph nodes. Dendritic Cells. Berlin, 2009, pp. 31–49.HLA-G expression levels influence the tolerogenic activity of human DC-10 / G. Amodio [et al.] // Haematologica. – 2015. – Vol. 100, N 4. – P. 548–557. https://doi.org/10.3324/haematol.2014.113803Amodio G., Comi M., Tomasoni D., Gianolini M. E., Rizzo R., LeMaoult J., Roncarolo M.-G., Gregori S. HLA-G expression levels influence the tolerogenic activity of human DC-10. Haematologica, 2015, vol. 100, no. 4, pp. 548–557. https://doi.org/10.3324/haematol.2014.113803Boltjes, A. Human dendritic cell functional specialization in steady-state and inflammation / A. Boltjes, F. van Wijk // Frontiers in Immunology. – 2014. – Vol. 5. – Art. 131. https://doi.org/10.3389/fimmu.2014.00131Boltjes A., van Wijk F. Human dendritic cell functional specialization in steady-state and inflammation. Frontiers in Immunology, 2014, vol. 5, art. 131. https://doi.org/10.3389/fimmu.2014.00131In vitro maturation and migration of immature dendritic cells after chemokine receptor 7 transfection / H.-M. Xin [et al.] // Can. J. Microbiol. – 2009. – Vol. 55, N 7. – P. 859–866. https://doi.org/10.1139/w09-041Xin H.-M., Peng Y.-Z., Yuan Z.-Q., Guo H. In vitro maturation and migration of immature dendritic cells after chemokine receptor 7 transfection. Canadian Journal of Microbiology, 2009, vol. 55, no. 7, pp. 859–866. https://doi. org/10.1139/w09-041Chu, J. The central role of dendritic cells in immunity / J. Chu, R. D. Salter // Dendritic Cells in Cancer / ed. : M. R. Shurin, R. D. Salter. – New York, 2009. – P. 1–10.Chu J., Salter R. D. The central role of dendritic cells in immunity. Dendritic Cells in Cancer. New York, 2009, pp. 1–10.The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting / M. Merad [et al.] // Annu. Rev. Immunol. – 2013. – Vol. 31, N 1. – P. 563–604. https://doi.org/10.1146/ annurev-immunol-020711-074950Merad M., Sathe P., Helft J., Miller J., Mortha A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annual Review of Immunology, 2013, vol. 31, no. 1, pp. 563–604. https://doi.org/10.1146/annurev-immunol-020711-074950A CD1a+ /CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells / T. Ito [et al.] // J. Immunol. – 1999. – Vol. 163, N 3. – P. 1409–1419.Ito T., Inaba M., Inaba K., Toki J., Sogo S., Iguchi T., Adachi Y., Yamaguchi K., Amakawa R., Valladeau J., Saeland S., Fukuhara S., Ikehara S. A CD1a+ /CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells. Journal of Immunology, 1999, vol. 163, no. 3, pp. 1409–1419.Dendritic cells in autoimmune diseases / B. Ludewig [et al.] // Curr. Opin. Immunol. – 2001. – Vol. 13, N 6. – P. 657– 662. https://doi.org/10.1016/S0952-7915(01)00275-8Ludewig B., Junt T., Hengartner H., Zinkernagel R. M. Dendritic cells in autoimmune diseases. Current Opinion in Immunology, 2001, vol. 13, no. 6, pp. 657–662. https://doi.org/10.1016/S0952-7915(01)00275-8Kushwah, R. Role of dendritic cells in the induction of regulatory T cells / R. Kushwah, J. Hu // Cell Biosci. – 2011. – Vol. 1. – Art. 20. https://doi.org/10.1186/2045-3701-1-20Kushwah R., Hu J. Role of dendritic cells in the induction of regulatory T cells. Cell and Bioscience, 2011, vol. 1, art. 20. https://doi.org/10.1186/2045-3701-1-20Diebold, S. S. Activation of dendritic cells by toll-like receptors and C-type lectins / S. S. Diebold // Dendritic Cells / ed. : G. Lombardi, Y. Riffo-Vasquez. – Berlin, 2009. – P. 3–30.Diebold S. S. Activation of dendritic cells by toll-like receptors and C-type lectins. Dendritic Cells, Berlin, 2009, pp. 3–30.Production of large numbers of plasmacytoid dendritic cells with functional activities from CD34+ hematopoietic progenitor cells: use of interleukin-3 / S. Demoulin [et al.] // Exp. Hematol. – 2012. – Vol. 40, N 4. – P. 268–278. https://doi. org/10.1016/j.exphem.2012.01.002Demoulin S., Roncarati P., Delvenne P., Hubert P. Production of large numbers of plasmacytoid dendritic cells with functional activities from CD34+ hematopoietic progenitor cells: use of interleukin-3. Experimental Hematology, 2012, vol. 40, no. 4, pp. 268–278. https://doi.org/10.1016/j.exphem.2012.01.002Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation / D. A. Chistiakov [et al.] // Frontiers in Physiology. – 2014. – Vol. 5. – Art. 279. https://doi.org/10.3389/fphys.2014.00279Chistiakov D. A., Orekhov A. N., Sobenin I. A., Bobryshev Y. V. Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation. Frontiers in Physiology, 2014, vol. 5, art. 279. https://doi.org/10.3389/ fphys.2014.00279Иммунофенотип и функциональные свойства моноцитарных дендритных клеток больных раком молочной железы / Л. П. Титов [и др.] // Здравоохранение. – 2010. – № 10. – С. 52–55.Titov L. P., Goncharov A. E., Putyrskii L. A., Koshelev S. V., Kosheleva M. I., Putyrskii Yu. L. Immunophenotype and function of monocyte-derived dendritic cells obtained from patients with breast cancer. Zdravookhranenie = Healthcare, 2010, no. 10, pp. 52–55 (in Russian).Kahler, D. J. T cell regulatory plasmacytoid dendritic cells expressing indoleamine 2,3 dioxygenase / D. J. Kahler, A. L. Mellor // Dendritic Cells / ed. : G. Lombardi, Y. Riffo-Vasquez. – Berlin, 2009. – P. 165–196.Kahler D. J., Mellor A. L.T cell regulatory plasmacytoid dendritic cells expressing indoleamine 2,3 dioxygenase. Dendritic Cells. Berlin, 2009, pp. 165–196.Altered maturation of peripheral blood dendritic cells in patients with breast cancer / S. Della Bella [et al.] // Br. J. Cancer. – 2003. – Vol. 89, N 8. – P. 1463–1472. https://doi.org/10.1038/sj.bjc.6601243Della Bella S., Gennaro M., Vaccari M., Ferraris C., Nicola S., Riva A., Clerici M., Greco M., Villa M. L. Altered maturation of peripheral blood dendritic cells in patients with breast cancer. British Journal of Cancer, 2003, vol. 89, no. 8, pp. 1463–1472. https://doi.org/10.1038/sj.bjc.6601243Титов, Л. П. Противоопухолевый иммунитет и иммунотерапия онкозаболеваний / Л. П. Титов // Вес. Нац. aкад. навук Беларусі. Сер. мед. навук. – 2002. – № 2. – С. 103–116.Titov L. P. Antineoplastic immunity and immunotherapy of oncological diseases. Vestsi Natsyyanal’nai akademii navuk Belarusi. Seriya meditsinskikh navuk = Proceedings of the National Academy of Sciences of Belarus. Medical series, 2002, no. 2, pp. 103–116 (in Russian).Ginhoux, F. Ontogeny and homeostasis of Langerhans cells / F. Ginhoux, M. Merad // Immunol. Cell Biol. – 2010. – Vol. 88, N 4. – P. 387–392. https://doi.org/10.1038/icb.2010.38Ginhoux F., Merad M. Ontogeny and homeostasis of Langerhans cells. Immunology and Cell Biology, 2010, vol. 88, no. 4, pp. 387–392. https://doi.org/10.1038/icb.2010.38Communication between human dendritic cell subsets in tuberculosis: requirements for naive CD4+ T cell stimulation / L. Lozza [et al.] // Front. Immunol. – 2014. – Vol. 5. – Art. 324. https://doi.org/10.3389/fimmu.2014.00324Lozza L., Farinacci M., Bechtle M., Stäber M., Zedler U., Baiocchini A., del Nonno F., Kaufmann S. H. E. Communication between human dendritic cell subsets in tuberculosis: requirements for naive CD4+ T cell stimulation. Frontiers in Immunology, 2014, vol. 5, art. 324. https://doi.org/10.3389/fimmu.2014.00324Kushwah, R. Complexity of dendritic cell subsets and their function in the host immune system / R. Kushwah, J. Hu // Immunology. – 2011. – Vol. 133, N 4. – P. 409–419. https://doi.org/10.1111/j.1365-2567.2011.03457.xKushwah R., Hu J. Complexity of dendritic cell subsets and their function in the host immune system. Immunology, 2011, vol. 133, no. 4, pp. 409–419. https://doi.org/10.1111/j.1365-2567.2011.03457.xCirculating dendritic cells and interferon-alpha production in patients with tuberculosis: correlation with clinical outcome and treatment response / M. Lichtner [et al.] // Clin. Exp. Immunol. – 2006. – Vol. 143, N 2. – P. 329–337. https://doi. org/10.1111/j.1365-2249.2005.02994.xLichtner M., Rossi R., Mengoni F., Vignoli S., Colacchia B., Massetti A. P., Kamga I., Hosmalin A., Vullo V., Mastroianni C. M. Circulating dendritic cells and interferon-alpha production in patients with tuberculosis: correlation with clinical outcome and treatment response. Clinical and Experimental Immunology, 2006, vol. 143, no. 2, pp. 329–337. https:// doi.org/10.1111/j.1365-2249.2005.02994.xEl Shikh, M. E. Follicular dendritic cells in health and disease / M. E. El Shikh, C. Pitzalis // Front. Immunol. – 2012. – Vol. 3. – Art. 292. https://doi.org/10.3389/fimmu.2012.00292El Shikh M. E., Pitzalis C. Follicular dendritic cells in health and disease. Frontiers in Immunology, 2012, vol. 3, art. 292. https://doi.org/10.3389/fimmu.2012.00292Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine / K. L. Lewis [et al.] // Immunity. – 2011. – Vol. 35, N 5. – P. 780–791. https://doi.org/10.1016/j.immuni.2011.08.013Lewis K. L., Caton M. L., Bogunovic M., Greter M., Grajkowska L. T., Ng D., Klinakis A., Charo I. F., Jung S., Gommerman J. L., Ivanov I. I., Liu K., Merad M., Reizis B. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity, 2011, vol. 35, no. 5, pp. 780–791. https://doi.org/10.1016/j. immuni.2011.08.013Lindstedt, M. Gene family clustering identifies functionally associated subsets of human in vivo blood and tonsillar dendritic cells / M. Lindstedt, K. Lundberg, C. A. Borrebaeck // J. Immunol. – 2005. – Vol. 175, N 8. – P. 4839–4846. https:// doi.org/10.4049/jimmunol.175.8.4839Lindstedt M., Lundberg K., Borrebaeck C. A. Gene family clustering identifies functionally associated subsets of human in vivo blood and tonsillar dendritic cells. Journal of Immunology, 2005, vol. 175, no. 8, pp. 4839–4846. https://doi. org/10.4049/jimmunol.175.8.4839Origin of the lamina propria dendritic cell network / M. Bogunovic [et al.] // Immunity. – 2009. – Vol. 31, N 3. – P. 513–525. https://doi.org/10.1016/j.immuni.2009.08.010Bogunovic M., Ginhoux F., Helft J., Shang L., Hashimoto D., Greter M., Liu K., Jakubzick C., Ingersoll M. A., Leboeuf M., Stanley E. R., Nussenzweig M., Lira S. A., Randolph G. J., Merad M. Origin of the lamina propria dendritic cell network. Immunity, 2009, vol. 31, no. 3, pp. 513–525. https://doi.org/10.1016/j.immuni.2009.08.010Dendritic cells: biology of the skin / M. J. Toebak [et al.] // Contact Dermatitis. – 2009. – Vol. 60, N 1. – P. 2–20. https://doi.org/10.1111/j.1600-0536.2008.01443.xToebak M. J., Gibbs S., Bruynzeel D. P., Scheper R. J., Rustemeyer T. Dendritic cells: biology of the skin. Contact Dermatitis, 2009, vol. 60, no. 1, pp. 2–20. https://doi.org/10.1111/j.1600-0536.2008.01443.xLi, H. Tolerogenic dendritic cells and their applications in transplantation / H. Li, B. Shi // Cell. Mol. Immunol. – 2015. – Vol. 12, N 1. – P. 24–30. https://doi.org/10.1038/cmi.2014.52Li H., Shi B. Tolerogenic dendritic cells and their applications in transplantation. Cellular and Molecular Immunology, 2015, vol. 12, no. 1, pp. 24–30. https://doi.org/10.1038/cmi.2014.52Sim,W. J. Metabolism is central to tolerogenic dendritic cell function / W. J. Sim, P. J. Ahl, J. E. Connolly // Mediat. Inflam. – 2016. – Vol. 2016. – Art. 2636701. https://doi.org/10.1155/2016/2636701Sim W. J., Ahl P. J., Connolly J. E. Metabolism is central to tolerogenic dendritic cell function. Mediators of Inflammation, 2016, vol. 2016, art. 2636701. https://doi.org/10.1155/2016/2636701Rheumatoid arthritis synovium contains plasmacytoid dendritic cells / L. L. Cavanagh [et al.] // Arthritis Res. Ther. – 2005. – Vol. 7, N 2. – P. R230–R240. https://doi.org/10.1186/ar1467Cavanagh L. L., Boyce A., Smith L., Padmanabha J., Filgueira L., Pietschmann P., Thomas R. Rheumatoid arthritis synovium contains plasmacytoid dendritic cells. Arthritis Research and Therapy, 2005, vol. 7, no. 2, pp. R230–240. https:// doi.org/10.1186/ar1467Gabrilovich, D. I. Myeloid-derived suppressor cells as regulators of the immune system / D. I. Gabrilovich, S. Nagaraj // Nat. Rev. Immunol. – 2009. – Vol. 9, N 3. – P. 162–174. https://doi.org/10.1038/nri2506Gabrilovich D. I., Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nature Reviews Immunology, 2009, vol. 9, no. 3, pp. 162–174. https://doi.org/10.1038/nri2506Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards / V. Bronte [et al.] // Nat. Commun. – 2016. – Vol. 7. – Art. 12150. https://doi.org/10.1038/ncomms12150Bronte V., Brandau S., Chen S. H., Colombo M. P., Frey A. B., Greten T. F., Mandruzzato S., Murray P. J., Ochoa A., Ostrand-Rosenberg S., Rodriguez P. C., Sica A., Umansky V., Vonderheide R. H., Gabrilovich D. I. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nature Communications, 2016, vol. 7, art. 12150. https://doi.org/10.1038/ncomms12150Титов, Л. П. Регуляция экспрессии генов иммунной системы и ее оценка методом микроэррей / Л. П. Титов // 90 лет в авангарде микробиологической науки Беларуси : сб. тр. Респ. науч.-практ. конф. с междунар. участием, посвящ. 125-летию со дня рождения Б. Я. Эльберта, Минск, 18 дек. 2015 г. / Белорус. гос. мед. ун-т ; под ред. Л. П. Титова. – Минск, 2015. – С. 144–163.Titov L. P. Regulation of the expression of the immune system genes and its evaluation by microarrays. 90 let v avangarde mikrobiologicheskoi nauki Belarusi: sbornik trudov Respublikanskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem, posvyashchennoi 125-letiyu so dnya rozhdeniya B. Ya. El’berta (Minsk, 18 dekabrya 2015 g.) [90 years in the vanguard of the microbiological science of Belarus: a collection of works of the Republican scientific and practical conference with international participation, dedicated to the 125th anniversary of the birth of B. Ya. Elbert (Minsk, December 18, 2015)]. Minsk, 2015, pp. 144–163 (in Russian).Титов, Л. П. Микро-РНК: новый класс регуляторных молекул иммунного ответа и инфекционного процесса / Л. П. Титов // Современные проблемы инфекционной патологии человека : сб. науч. тр. / Респ. науч.-практ. центр эпидемиологии и микробиологии ; под ред. Л. П. Титова (гл. ред.) [и др.]. – Минск, 2012. – Вып. 5. – С. 256–261.Titov L. P. Micro-RNAs: a new class of regulatory molecules of immune response and infectious processes. Sovremennye problemy infektsionnoi patologii cheloveka: sbornik nauchnykh trudov [Current problems of human infectious pathology: scientific works collection]. Minsk, 2012, iss. 5, pp. 256–261 (in Russian).Гончаров, А. Е. Иммунобиологический эффект последовательностей ДНК бактерий рода Klebsiella, содержащих CрG мотивы, на моноцитарные дендритные клетки / А. Е. Гончаров, Л. П. Титов // Здравоохранение. – 2007. – № 11. – С. 9–12.Goncharov A. E., Titov L. P. Immunobiological effect of DNA sequences of bacteria of the genus Klebsiella, containing CpG motifs, on monocytic dendritic cells. Zdravookhranenie = Healthcare, 2007, no. 11, pp. 9–12 (in Russian).Характеристика экспрессии костимуляторных и адгезивных молекул миелоидных и плазмацитоидных дендритных клеток пациентов с рассеянным склерозом / А. Е. Гончаров [и др.] // Докл. Нац. акад. наук Беларуси. – 2010. – Т. 54, № 6. – С. 82–88.Goncharov A. E., Titov L. P., Romanova I. V., Drakina S. A. Characteristic expression of costimulatory and adhesion molecules of myeloid and plasmacytoid dendritic cells in patients with multiple sclerosis. Doklady Natsional’noi akademii nauk Belarusi = Reports of the National Academy of Sciences of Belarus, 2010, vol. 54, no. 6, pp. 82–88 (in Russian).Мононуклеарные фагоциты, регуляторные Т-лимфоциты, циркулирующие стволовые и эндотелиальные клетки у пациентов с атеросклеротической аневризмой аорты / Л. П. Титов [и др.] // Здравоохранение. – 2016. – № 1. – С. 4–10.Titov L. P., Krylov V. P., Hancharou A. Y., Reut L. I., Shafalovich A. V., Gayduk V. N., Murashko A. S. Mononuclear phagocytes, regulatory T-lymphocytes, circulating stem and endothelial cells in patients with atherosclerotic aortic aneurysm. Zdravookhranenie = Healthcare, 2016, no. 1, pp. 4–10 (in Russian).Иммунофизиологическая и клиническая эффективность иммунотерапии пациентов с мультирезистентным туберкулезом легких нановакциной на основе аутологичных моноцитарных дендритных клеток / Л. П. Титов [и др.] // Здравоохранение. – 2012. – № 1. – С. 53–60.Titov L. P., Goncharov A. E., Skryagina E. M., Shpakovskaya N. S., Antonova N. P., Zalutskaya O. M., Novokhat’ko T. S. Immunophysiological and clinical efficiency of immunotherapy of patients with multiresistant tuberculosis of lungs by nanovaccine based on autologous monocytic dendritic cells. Zdravookhranenie = Healthcare, 2012, no. 1, pp. 53–60 (in Russian).Противорецидивная иммунотерапия рака молочной железы вакциной на основе аутологичных дендритных клеток / А. Е. Гончаров [и др.] // Вес. Нац. aкад. навук Беларусі. Сер. мед. навук. – 2014. – № 3. – С. 4–19.Goncharov A. E., Titov L. P., Koshelev S. V., Putyrskii L. A., Dubrovskii A. Ch., Romanova I. V., Kosheleva M. I., Shapoval E. V., Smolyakova R. M., Besman E. V. Anti-relapse immunotherapy of patients with breast cancer using autologous dendritic cell-based vaccine. Vestsi Natsyyanal’nai akademii navuk Belarusi. Seriya meditsinskikh navuk = Proceedings of the National Academy of Sciences of Belarus. Medical series, 2014, no. 3, pp. 4–19 (in Russian).Ferlazzo, G. Dendritic cell-based immunotherapy of cancer: current pitfalls and challenges / G. Ferlazzo, L. Moretta // Dendritic cells: types, life cycles and biological functions / ed. L. C. Welles. – New York, 2010. – P. 179–185.Ferlazzo G., Moretta L. Dendritic cell-based immunotherapy of cancer: current pitfalls and challenges. Dendritic Cells: Types, Life Cycles and Biological Functions. New York, Nova Science Publ., 2010, pp. 179–185.Adorini, L. Induction of tolerogenic dendritic cells by vitamin D receptor agonists / L. Adorini, G. Penna // Dendritic Cells / ed. : G. Lombardi, Y. Riffo-Vasquez. – Berlin, 2009. – P. 251–273.Adorini L., Penna G. Induction of tolerogenic dendritic cells by vitamin D receptor agonists. Dendritic Cells. Berlin, Springer-Verlag Publ., 2009, pp. 251–273.Hilkens, C. M. Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now? / C. M. Hilkens, J. D. Isaacs // Clin. Exp. Immunol. – 2013. – Vol. 172, N 2. – P. 148–157. https://doi.org/10.1111/cei.12038Hilkens C. M., Isaacs J. D. Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now? Clinical and Experimental Immunology, 2013, vol. 172, no. 2, pp. 148–157. https://doi.org/10.1111/cei.12038

The authors declare that there are no conflicts of interest present.