vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestim-332Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEОЦЕНКА АНТИНОЦИЦЕПТИВНОГО ДЕЙСТВИЯ АМИДОВ ПАЛЬМИТИНОВОЙ КИСЛОТЫASSESSMENT OF ANTINOCICEPTIVE EFFECTS OF PALMITIC ACID AMIDESМелик-КасумовТ. Б.Melik-KasumovT. V.

канд. биол. наук, ст. науч. сотрудник лаборатории модуляции функций организма

Ph. D. (Biol.), Senior Researcher of the laboratory of body function modulation

tigranbmk@gmail.comПавлютьТ. О.PavlutT. O.

науч. сотрудник лаборатории модуляции функций организма

Researcher of the laboratory of body function modulation

tanja281286@mail.ruЖаворонокИ. П.ZhavoronokI. P.

канд. биол. наук, науч. сотрудник лаборатории модуляции функций организма

Ph. D. (Biol.), Researcher of the laboratory of body function modulation

iri8308@yandex.ruАнтиповаО. А.AntipovaO. A.

мл. науч. сотрудник лаборатории модуляции функций организма

Junior Researcher of the laboratory of body function modulation

mayuha@yandex.ruПехтереваЕ. И.PehterevaE. I.

мл. науч. сотрудник лаборатории модуляции функций организма

Junior Researcher of the laboratory of body function modulation

eleivatar@list.ruВасилькевичА. И.VasilkevichA. I.

науч. сотрудник лаборатории химии липидов

Researcher of the laboratory of lipid chemistry

vasilkevich@iboch.bas-net.byКисельМ. А.KiselM. A.

д-р хим. наук, заведующий лабораторией химии липидов

D. Sc. (Chem.), Head of the laboratory of lipid chemistry

kisel@iboch.bas-net.byМолчановаА. Ю.MolchanovaA. Yu.

канд. биол. наук, заведующая лабораторией модуляции функций организма

Ph. D., Head of the laboratory of body function modulation

alla@fizio.bas-net.byИнститут физиологии НАН БеларусиInstitute of Physiology of the National Academy of Sciences of BelarusИнститут биоорганической химии НАН БеларусиInstitute of Bioorganic Chemistry of the National Academy of Sciences of Belarus201613012017042531Copyright © Мелик-Касумов Т.Б., Павлють Т.О., Жаворонок И.П., Антипова О.А., Пехтерева Е.И., Василькевич А.И., Кисель М.А., Молчанова А.Ю., 20172017Мелик-Касумов Т.Б., Павлють Т.О., Жаворонок И.П., Антипова О.А., Пехтерева Е.И., Василькевич А.И., Кисель М.А., Молчанова А.Ю.Melik-Kasumov T.V., Pavlut T.O., Zhavoronok I.P., Antipova O.A., Pehtereva E.I., Vasilkevich A.I., Kisel M.A., Molchanova A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/332

В экспериментах на крысах с использованием поведенческих тестов исследовано антиноцицептивное действие некоторых амидов пальмитиновой кислоты. Установлено, что однократная инъекция N-пальмитоилглицина, N-паль-митоилсеринола и N-пальмитоил-5-аминолевулиновой кислоты в дозе 2,5 мкмоль/кг в разной степени увеличивает болевой порог при предъявлении механического или термического болевого стимула. Указанные амиды могут, таким образом, играть важную роль в болевой чувствительности, в частности, за счет участия в процессах липидной сигнализации.

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The authors declare that there are no conflicts of interest present.