vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestim-324Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEГЕПАТОПРОТЕКТИВНЫЙ ЭФФЕКТ С23-ПРОИЗВОДНОГО УРСОДЕЗОКСИХОЛЕВОЙ КИСЛОТЫ ПРИ ЭКСПЕРИМЕНТАЛЬНОМ НЕАЛКОГОЛЬНОМ СТЕАТОГЕПАТИТЕ У КРЫСHEPATOPROTECTIVE EFFECT OF THE C23-DERIVATIVE OF THE URSODEOXYCHOLIC ACID IN EXPERIMENTAL NONALCOHOLIC STEATOHEPATITIS OF RATSБЕЛОНОВСКАЯЕ. Б.BELONOVSKAYAE. B.ms.belonovskaya@yandex.ruЛУКИВСКАЯО. Я.LUKIVSKAYAO. Y.НАРУТАЕ. Е.NARUTAE. E.КИРКОС. Н.KIRKOS. N.АБАКУМОВВ. З.ABAKUMOVV. Z.КУЗЬМИЦКАЯИ. А.KUZMITSKAYAI. A.БУКОВ. У.BUKOV. U.Институт биохимии биологически активных соединений НАН БеларусиInstitute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of BelarusГродненский государственный медицинский университетGrodno State Medical University201619112016038085Copyright © БЕЛОНОВСКАЯ Е.Б., ЛУКИВСКАЯ О.Я., НАРУТА Е.Е., КИРКО С.Н., АБАКУМОВ В.З., КУЗЬМИЦКАЯ И.А., БУКО В.У., 20162016БЕЛОНОВСКАЯ Е.Б., ЛУКИВСКАЯ О.Я., НАРУТА Е.Е., КИРКО С.Н., АБАКУМОВ В.З., КУЗЬМИЦКАЯ И.А., БУКО В.У.BELONOVSKAYA E.B., LUKIVSKAYA O.Y., NARUTA E.E., KIRKO S.N., ABAKUMOV V.Z., KUZMITSKAYA I.A., BUKO V.U.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/324

Исследована эффективность применения производного урсодезоксихолевой кислоты (С23- гомолог УДХК в дозе 38,6 мг/кг, эквимолярной дозе УДХК 40 мг/кг) при экспериментальном неалкогольном стеатогепатите (НАСГ) у крыс. Результаты исследования показали, что С23-гомолог УДХК наравне с УДХК оказывает выраженный гепатопротективный эффект при лечении НАСГ, проявляя противовоспалительную активность и умеренное липидснижающее действие. В отличие от исходного соединения, производное УДХК обладает более выраженным антиоксидантным потенциалом.

The effects of the C23-derivative of ursodeoxycholic acid (nor-UDCA) in rats with nonalcoholic steatohepatitis (NASH) were studied. NASH was induced by the feeding of a liquid high-fat diet of Lieber-DeCarli for 16 weeks. Rats were daily administered with the derivative of UDCA in a dose of 38.6 mg/kg (equimolar to 40 mg/kg UDCA) by oral gavage for the last 4 weeks. Our study demonstrated that the treatment with nor-UDCA improved the liver steatosis and decreased the inflammation and the NASH-induced lipid peroxidation. The obtained experimental data allow us to make a conclusion that the derivative of UDCA in the same extent with UDCA possessed hepatoprotective properties but it has a more antioxidant potential than a mother compound.

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The authors declare that there are no conflicts of interest present.